小剂量硫唑嘌呤治疗自身免疫性大疱性皮肤病的回顾性分析 : = Retrospective Analysis of the Treatment of Autoimmune Bullous Skin Disorders by Low Dose Azathioprine
目的回顾性分析小剂量硫唑嘌呤(AZA)治疗自身免疫性大疱性皮肤病的疗效及安全性。方法分析2017年1月—2018年6月在我科住院的120例自身免疫性大疱性皮肤病患者治疗中糖皮质激素及AZA的使用情况、硫嘌呤甲基转移酶(TPMT)突变基因检测情况,AZA的疗效及不良反应的发生情况。结果 120例患者中33例使用了AZA 100 mg/d,患者根据自身免疫性大疱性皮肤病(ABSIS)评分分为轻度21例,中度77例,重度22例。其中大疱性类天疱疮59例,5例患者使用AZA,均为单纯使用激素后效果不佳的患者,使用AZA后起效时间为12～21 d,平均起效时间(15.60±2.32)d;天疱疮患者61例,28例患者使用AZA,与未使用AZA组比较中度和重度患者激素控制量显著下降。30例TPMT基因突变检测阴性的患者有2例使用AZA后仍出现严重不良反应。结论 AZA组需要更小的激素控制量,对于单用激素效果不佳的患者联合AZA可以更好控制病情,但是要注意AZA的不良反应,对TPMT基因突变检测阴性的患者也应严密检测其不良反应。.
Objective In order to evaluate the clinical efficacy and safety of low dose azathioprine(AZA) in the treatment of autoimmune bullous skin disorders. Methods Retrospective analysis of the incidence of glucocorticoid and azathioprine usage,TPMT gene mutation prevalence and therapeutic effects as well as adverse drug reaction incidence from 120 autoimmune bullous dermatosis patients who were treated in our department from Janury 2017 to June 2018. Results Out of120 patients,33 patients were treated with AZA 100 mg a day. Patients were divided into mild(21 cases),mediate(77 cases)and severe(22 cases) groups according to the ABSIS scores. Out of 120 patients,59 cases were diagnosed with bullous pemphigoid,out of which five patients were treated with AZA after unsatisfactory systemic corticosteroids monotherapy. AZA treatment took effect after 12 to 21 days on patients diagnosed with bullous pemphigoid,with an average of 15.60±2.32 days.Out of 61 patients with pemphigus,28 cases were treated with AZA,with significant decreasing of steroids usage compared to their counterparts from the mediate and severe groups. Meanwhile,two out of 30 patients with negative TPMT gene mutation test results still developed severe adverse drug reaction. Conclusion Combination therapy of AZA and systemic corticosteroid administration presents better disease control outcome if steroid monotherapy did not yield satisfactory theraputic effects. But the adverse drug reaction of AZA should be carefully supervised even within the patients who has negative TPMT gene mutation test results..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019-08-30 2019 |
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| Erschienen: |
2019-08-30 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2019 |
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| Enthalten in: |
Zhong guo zhong xi yi jie he pi fu xing bing xue za zhi - (2019), 04 vom: 30. Aug., Seite 289-292 Original Letters: Enthalten in 中国中西医结合皮肤性病学杂志 (DE-600)2993848-X (DE-600)2993848-X 天津市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Retrospective Analysis of the Treatment of Autoimmune Bullous Skin Disorders by Low Dose Azathioprine |
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| Beteiligte Personen: |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Themen: |
医药、卫生 |
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| Anmerkungen: |
Author info:Ke Dan;Wan Yuanfang;Chongqing Hospital of Traditional Chinese Medicine |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ637447352 |
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| 245 | 1 | 0 | |a 小剂量硫唑嘌呤治疗自身免疫性大疱性皮肤病的回顾性分析 |b = Retrospective Analysis of the Treatment of Autoimmune Bullous Skin Disorders by Low Dose Azathioprine |
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| 520 | |a 目的回顾性分析小剂量硫唑嘌呤(AZA)治疗自身免疫性大疱性皮肤病的疗效及安全性。方法分析2017年1月—2018年6月在我科住院的120例自身免疫性大疱性皮肤病患者治疗中糖皮质激素及AZA的使用情况、硫嘌呤甲基转移酶(TPMT)突变基因检测情况,AZA的疗效及不良反应的发生情况。结果 120例患者中33例使用了AZA 100 mg/d,患者根据自身免疫性大疱性皮肤病(ABSIS)评分分为轻度21例,中度77例,重度22例。其中大疱性类天疱疮59例,5例患者使用AZA,均为单纯使用激素后效果不佳的患者,使用AZA后起效时间为12～21 d,平均起效时间(15.60±2.32)d;天疱疮患者61例,28例患者使用AZA,与未使用AZA组比较中度和重度患者激素控制量显著下降。30例TPMT基因突变检测阴性的患者有2例使用AZA后仍出现严重不良反应。结论 AZA组需要更小的激素控制量,对于单用激素效果不佳的患者联合AZA可以更好控制病情,但是要注意AZA的不良反应,对TPMT基因突变检测阴性的患者也应严密检测其不良反应。 | ||
| 520 | |a Objective In order to evaluate the clinical efficacy and safety of low dose azathioprine(AZA) in the treatment of autoimmune bullous skin disorders. Methods Retrospective analysis of the incidence of glucocorticoid and azathioprine usage,TPMT gene mutation prevalence and therapeutic effects as well as adverse drug reaction incidence from 120 autoimmune bullous dermatosis patients who were treated in our department from Janury 2017 to June 2018. Results Out of120 patients,33 patients were treated with AZA 100 mg a day. Patients were divided into mild(21 cases),mediate(77 cases)and severe(22 cases) groups according to the ABSIS scores. Out of 120 patients,59 cases were diagnosed with bullous pemphigoid,out of which five patients were treated with AZA after unsatisfactory systemic corticosteroids monotherapy. AZA treatment took effect after 12 to 21 days on patients diagnosed with bullous pemphigoid,with an average of 15.60±2.32 days.Out of 61 patients with pemphigus,28 cases were treated with AZA,with significant decreasing of steroids usage compared to their counterparts from the mediate and severe groups. Meanwhile,two out of 30 patients with negative TPMT gene mutation test results still developed severe adverse drug reaction. Conclusion Combination therapy of AZA and systemic corticosteroid administration presents better disease control outcome if steroid monotherapy did not yield satisfactory theraputic effects. But the adverse drug reaction of AZA should be carefully supervised even within the patients who has negative TPMT gene mutation test results. | ||
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| 650 | 4 | |a 皮肤病学与性病学 | |
| 650 | 4 | |a 医药、卫生 | |
| 650 | 4 | |a Dermatosis and Venereal Disease | |
| 650 | 4 | |a 医药卫生科技 | |
| 650 | 4 | |a Medicine & Public Health | |
| 650 | 4 | |a 自身免疫性大疱性皮肤病 | |
| 650 | 4 | |a 硫唑嘌呤 | |
| 650 | 4 | |a 回顾性研究 | |
| 650 | 4 | |a Autoimmune bullous skin disorders | |
| 650 | 4 | |a Azathioprine | |
| 650 | 4 | |a Retrospective | |
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