ACE2基因多态性与冠心病的相关性研究 : = Association of ACE2 Gene Polymorphism with Coronary Heart Disease
目的研究血管紧张素转换酶2(ACE2)基因多态性和冠心病(CHD)的相关性。方法入选179例疑似冠心病行冠脉造影(CAG)的患者,按CAG结果分为冠心病组和非冠心病组。检测4个ACE2 tag SNPs(rs2074192,rs4646171,rs4646155和rs2106809)的基因型。结果因ACE2基因位于X染色体,故按照性别进行比较。女性中,rs2106809位点TT+CT基因型携带者有较高的冠心病患病危险(P=0.027),logistic回归校正可能对CHD有影响的变量后,rs2106809多态在显性模型和女性CHD存在关联(P=0.014, OR=15.026,95%CI=1.731-130.443)。男性中,各位点两组间等位基因频率比较差异无统计学意义(P>0.05)。结论 ACE2基因中的常见变异可能影响女性CHD的发生。.
Objective To explore the association of angiotensin-converting enzyme 2(ACE2) gene polymorphism with coronary heart disease(CHD). Methods A total of 179 patients who were referred to coronary angiography(CAG) for the evaluation of suspected CHD were enrolled in the present study. Four ACE2 tag SNPs(rs2106809, rs2074192, rs4646155 and rs4646176) were genotyped. Results Analyses were conducted by gender, because the ACE2 gene is on the X chromosome. In female subjects, carriers of the rs2106809 TT+CT genotype were at higher risk of CHD(P=0.027). Subsequent stepwise logistic regression to adjust for covariates revealed that ACE2 rs2106809 was associated with CHD in female patients(P=0.014, OR=15.026, 95%CI= 1.731-130.443) in a dominant mode of inheritance. None of the polymorphisms had any association with CHD in male patients. Conclusion common genetic variants in the ACE2 gene might impact on CHD in females..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019-04-25 2019 |
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| Erschienen: |
2019-04-25 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2019 |
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| Enthalten in: |
Zhong guo fen zi xin zang bing xue za zhi - (2019), 02 vom: 25. Apr., Seite 2818-2822 Original Letters: Enthalten in 中国分子心脏病学杂志 (DE-600)2990880-2 (DE-600)2990880-2 北京市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Association of ACE2 Gene Polymorphism with Coronary Heart Disease |
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| Beteiligte Personen: |
周晓敏 [VerfasserIn] |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Anmerkungen: |
Author info:ZHOU Xiao-min;ZHANG Ping;LIANG Tao;LIU Dan;CHEN Yong-yue;YU Hui-min;The Second School of Clinical Medicine, Southern Medical University;Department of Cardiology.Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences;Department of Cardiology,Hoapital of Panyu District, Guangzhou;Department of Cardiology, Shantou Central Hospital and Affiliated Shantou Hospital of SunYat-sen University |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ632930659 |
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| 245 | 1 | 0 | |a ACE2基因多态性与冠心病的相关性研究 |b = Association of ACE2 Gene Polymorphism with Coronary Heart Disease |
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| 520 | |a 目的研究血管紧张素转换酶2(ACE2)基因多态性和冠心病(CHD)的相关性。方法入选179例疑似冠心病行冠脉造影(CAG)的患者,按CAG结果分为冠心病组和非冠心病组。检测4个ACE2 tag SNPs(rs2074192,rs4646171,rs4646155和rs2106809)的基因型。结果因ACE2基因位于X染色体,故按照性别进行比较。女性中,rs2106809位点TT+CT基因型携带者有较高的冠心病患病危险(P=0.027),logistic回归校正可能对CHD有影响的变量后,rs2106809多态在显性模型和女性CHD存在关联(P=0.014, OR=15.026,95%CI=1.731-130.443)。男性中,各位点两组间等位基因频率比较差异无统计学意义(P>0.05)。结论 ACE2基因中的常见变异可能影响女性CHD的发生。 | ||
| 520 | |a Objective To explore the association of angiotensin-converting enzyme 2(ACE2) gene polymorphism with coronary heart disease(CHD). Methods A total of 179 patients who were referred to coronary angiography(CAG) for the evaluation of suspected CHD were enrolled in the present study. Four ACE2 tag SNPs(rs2106809, rs2074192, rs4646155 and rs4646176) were genotyped. Results Analyses were conducted by gender, because the ACE2 gene is on the X chromosome. In female subjects, carriers of the rs2106809 TT+CT genotype were at higher risk of CHD(P=0.027). Subsequent stepwise logistic regression to adjust for covariates revealed that ACE2 rs2106809 was associated with CHD in female patients(P=0.014, OR=15.026, 95%CI= 1.731-130.443) in a dominant mode of inheritance. None of the polymorphisms had any association with CHD in male patients. Conclusion common genetic variants in the ACE2 gene might impact on CHD in females. | ||
| 610 | 2 | 4 | |a 南方医科大学第二临床医学院 |
| 610 | 2 | 4 | |a 广东省心血管病研究所心内科广东省人民医院广东省医学科学院 |
| 610 | 2 | 4 | |a 广州市番禺区中心医院心内科 |
| 610 | 2 | 4 | |a 汕头市中心医院心内科中山大学附属汕头医院 |
| 650 | 4 | |a 心脏、血管（循环系）疾病 | |
| 650 | 4 | |a 内科学 | |
| 650 | 4 | |a 医药、卫生 | |
| 650 | 4 | |a Cardiovascular System Disease | |
| 650 | 4 | |a 医药卫生科技 | |
| 650 | 4 | |a Medicine & Public Health | |
| 650 | 4 | |a 血管紧张素转换酶2 | |
| 650 | 4 | |a 冠心病 | |
| 650 | 4 | |a 单核苷酸基因多态性 | |
| 650 | 4 | |a angiotensin-converting enzyme 2 | |
| 650 | 4 | |a coronary heart disease | |
| 650 | 4 | |a single nucleotide polymorphism | |
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