网络构建技术在药物重定位研究中的应用 : = Application of network construction technology in drug repositioning
药物重定位就是老药新用,是指对已知的药物发掘其新的药效。对已知的药物重定位是研发药物策略中风险最低、效益最好的策略之一,也是解决新药开发中存在的投入高、成功率低问题的有效方法之一。老药新用的研究方法不断完善、不断推陈出新,并且计算机技术的飞速发展,推动了药物重定位的研究进入一个新的发展阶段。到目前为止,计算预测分析和实验筛选过程是老药新用研究的主要的2大方面,其中计算预测分析方法又分为3种主要的重定位方法:网络模型、小分子和药物靶标。在老药新用研究中越来越受关注的是网络模型。疾病关联网络、药物关联网络和蛋白质互作网络是网络模型中主要应用的3大网络,针对网络模型中3大网络的构建进行综述。.
Drug repositioning is a new use of old drugs, which refers to the discovery of new effects on known drugs. A known drug relocation is one of the least risky and most effective strategies in the development of drug strategies, and it is also one of the effective methods to solve the problems of high investment and low success rate in the development of new drugs. The research methods for the new use of old drugs have been continuously improved, and new innovations have been made, and the rapid development of computer technology has pushed the research of drug relocation into a new stage of development. So far, the calculation of predictive analysis and experimental screening process are the two major aspects of the new drug research, and the computational prediction analysis method is divided into three main relocation methods: network model, small molecule and drug target. More and more researchers pay attention to the network model in the study of new drug use. The disease association network, drug association network and protein interaction network are the three major networks in the network model, and the construction of the three networks in the network model is reviewed..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019-06-15 2019 |
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| Erschienen: |
2019-06-15 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2019 |
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| Enthalten in: |
Chen yang shi fan da xue xue bao. Zi ran ke xue ban - (2019), 03 vom: 15. Juni, Seite 244-249 Original Letters: Enthalten in 沈阳师范大学学报. 自然科学版 (DE-600)2989172-3 (DE-600)2989172-3 辽宁省沈阳市 |
| Reihe: |
China Academic Journals (CAJ), A, 理工A(数学物理力学天地生) = Mathematics/ Physics/ Mechanics/ Astronomy China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Application of network construction technology in drug repositioning |
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| Beteiligte Personen: |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Themen: |
医药、卫生 |
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| Anmerkungen: |
Author info:YANG Guang;HAI Boyu;College of Mathematics and Systems Science,Shenyang Normal University |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ631921702 |
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| 500 | |a Author info:YANG Guang;HAI Boyu;College of Mathematics and Systems Science,Shenyang Normal University | ||
| 520 | |a 药物重定位就是老药新用,是指对已知的药物发掘其新的药效。对已知的药物重定位是研发药物策略中风险最低、效益最好的策略之一,也是解决新药开发中存在的投入高、成功率低问题的有效方法之一。老药新用的研究方法不断完善、不断推陈出新,并且计算机技术的飞速发展,推动了药物重定位的研究进入一个新的发展阶段。到目前为止,计算预测分析和实验筛选过程是老药新用研究的主要的2大方面,其中计算预测分析方法又分为3种主要的重定位方法:网络模型、小分子和药物靶标。在老药新用研究中越来越受关注的是网络模型。疾病关联网络、药物关联网络和蛋白质互作网络是网络模型中主要应用的3大网络,针对网络模型中3大网络的构建进行综述。 | ||
| 520 | |a Drug repositioning is a new use of old drugs, which refers to the discovery of new effects on known drugs. A known drug relocation is one of the least risky and most effective strategies in the development of drug strategies, and it is also one of the effective methods to solve the problems of high investment and low success rate in the development of new drugs. The research methods for the new use of old drugs have been continuously improved, and new innovations have been made, and the rapid development of computer technology has pushed the research of drug relocation into a new stage of development. So far, the calculation of predictive analysis and experimental screening process are the two major aspects of the new drug research, and the computational prediction analysis method is divided into three main relocation methods: network model, small molecule and drug target. More and more researchers pay attention to the network model in the study of new drug use. The disease association network, drug association network and protein interaction network are the three major networks in the network model, and the construction of the three networks in the network model is reviewed. | ||
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| 650 | 4 | |a 药物 | |
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| 650 | 4 | |a drug | |
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