艾司西酞普兰联合坦度螺酮治疗老年女性冠心病继发焦虑抑郁障碍疗效观察 : = Clinical effects investigation of escitalopram assisted with tandospirone in the treatment of elderly female patients with coronary heart disease secondary to anxiety and depression
目的探讨艾司西酞普兰联合坦度螺酮治疗老年女性冠心病继发焦虑抑郁障碍疗效及安全性。方法研究对象选取老年女性冠心病继发焦虑抑郁障碍患者共100例,以随机抽签法分为对照组(50例)和观察组(50例),分别给予坦度螺酮单用和于艾司西酞普兰联用治疗;比较两组患者临床疗效和安全性。结果两组患者治疗前汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分、白细胞介素-18(IL-18)及髓过氧化物酶(MPO)水平组间比较差异无显著性(P>0.05)观察组患者治疗总有效率,治疗后HAMD评分、HAMA评分、IL-18及MPO水平均显著优于对照组(P<0.05);观察组患者再发心绞痛、严重心率失常及再发心肌梗死发生率均显著低于对照组(P<0.05);两组患者不良反应发生率比较差异无显著性(P>0.05)。结论艾司西酞普兰辅助坦度螺酮治疗老年女性冠心病继发焦虑抑郁障碍可有效缓解负面情绪状态症状,调节IL-18和MPO水平,预防心血管事件发生,且未增加药物不良反应风险。.
Objective To investigate the clinical effects and safety of escitalopram assisted with tandospirone in the treatment of elderly female patients with anxiety and depression secondary tocoronary heart disease Methods 100 elderly female patients with coronary heart disease secondary to anxiety and depression were chosen and randomly divided into both group including control group(50 patients)with tandospirone used alone and observation group(50 patients)with escitalopram assisted with tandospirone;and the clinical efficacy and safety of both groups were compared.Results There was no significant difference in the HAMD score,HAMA score,the levels of IL-18 and MPO between 2 groups(P>0.05). The clinical total efficacy,the HAMD score,HAMA score,the levels of IL-18 and MPO of observation group after treatment were significantly better than control group(P<0.05). The incidence of cardiovascular events of observation group were significantly lower than control group and before treatment(P<0.05). There was no significant difference in the adverse reaction incidence between two groups(P>0.05). Conclusion Escitalopram assisted with tandospirone in the treatment of elderly female patients with coronary heart disease secondary to anxiety and depression can efficiently relieve the negative mood symptoms,regulate the levels of IL-18 and MPO levels,prevent the cardiovascular events occurrence and not increase the risk of adverse drug reactions..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019-02-25 2019 |
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| Erschienen: |
2019-02-25 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2019 |
|---|---|
| Enthalten in: |
Guo ji jing shen bing xue za zhi - (2019), 01 vom: 25. Feb., Seite 137-139+146 Original Letters: Enthalten in 国际精神病学杂志 (DE-600)2991085-7 (DE-600)2991085-7 湖南省长沙市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Clinical effects investigation of escitalopram assisted with tandospirone in the treatment of elderly female patients with coronary heart disease secondary to anxiety and depression |
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| Beteiligte Personen: |
银贺 [VerfasserIn] |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Anmerkungen: |
Author info:YIN He;WEI Xin;GUO Cong;Psychiatric Department of Zhumadian Psychiatric Hospital |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ626926858 |
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| 245 | 1 | 0 | |a 艾司西酞普兰联合坦度螺酮治疗老年女性冠心病继发焦虑抑郁障碍疗效观察 |b = Clinical effects investigation of escitalopram assisted with tandospirone in the treatment of elderly female patients with coronary heart disease secondary to anxiety and depression |
| 246 | 3 | 1 | |a Clinical effects investigation of escitalopram assisted with tandospirone in the treatment of elderly female patients with coronary heart disease secondary to anxiety and depression |
| 264 | 1 | |c 2019-02-25 | |
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| 490 | 0 | |a China Academic Journals (CAJ) |a E |a 医药卫生科技 = Medicine & Public Health | |
| 500 | |a Author info:YIN He;WEI Xin;GUO Cong;Psychiatric Department of Zhumadian Psychiatric Hospital | ||
| 520 | |a 目的探讨艾司西酞普兰联合坦度螺酮治疗老年女性冠心病继发焦虑抑郁障碍疗效及安全性。方法研究对象选取老年女性冠心病继发焦虑抑郁障碍患者共100例,以随机抽签法分为对照组(50例)和观察组(50例),分别给予坦度螺酮单用和于艾司西酞普兰联用治疗;比较两组患者临床疗效和安全性。结果两组患者治疗前汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分、白细胞介素-18(IL-18)及髓过氧化物酶(MPO)水平组间比较差异无显著性(P>0.05)观察组患者治疗总有效率,治疗后HAMD评分、HAMA评分、IL-18及MPO水平均显著优于对照组(P<0.05);观察组患者再发心绞痛、严重心率失常及再发心肌梗死发生率均显著低于对照组(P<0.05);两组患者不良反应发生率比较差异无显著性(P>0.05)。结论艾司西酞普兰辅助坦度螺酮治疗老年女性冠心病继发焦虑抑郁障碍可有效缓解负面情绪状态症状,调节IL-18和MPO水平,预防心血管事件发生,且未增加药物不良反应风险。 | ||
| 520 | |a Objective To investigate the clinical effects and safety of escitalopram assisted with tandospirone in the treatment of elderly female patients with anxiety and depression secondary tocoronary heart disease Methods 100 elderly female patients with coronary heart disease secondary to anxiety and depression were chosen and randomly divided into both group including control group(50 patients)with tandospirone used alone and observation group(50 patients)with escitalopram assisted with tandospirone;and the clinical efficacy and safety of both groups were compared.Results There was no significant difference in the HAMD score,HAMA score,the levels of IL-18 and MPO between 2 groups(P>0.05). The clinical total efficacy,the HAMD score,HAMA score,the levels of IL-18 and MPO of observation group after treatment were significantly better than control group(P<0.05). The incidence of cardiovascular events of observation group were significantly lower than control group and before treatment(P<0.05). There was no significant difference in the adverse reaction incidence between two groups(P>0.05). Conclusion Escitalopram assisted with tandospirone in the treatment of elderly female patients with coronary heart disease secondary to anxiety and depression can efficiently relieve the negative mood symptoms,regulate the levels of IL-18 and MPO levels,prevent the cardiovascular events occurrence and not increase the risk of adverse drug reactions. | ||
| 610 | 2 | 4 | |a 河南省驻马店市精神病医院精神科 |
| 650 | 4 | |a 精神病学 | |
| 650 | 4 | |a 神经病学与精神病学 | |
| 650 | 4 | |a 医药、卫生 | |
| 650 | 4 | |a 心脏、血管（循环系）疾病 | |
| 650 | 4 | |a 内科学 | |
| 650 | 4 | |a Cardiovascular System Disease | |
| 650 | 4 | |a Psychiatry | |
| 650 | 4 | |a 医药卫生科技 | |
| 650 | 4 | |a Medicine & Public Health | |
| 650 | 4 | |a 艾司西酞普兰 | |
| 650 | 4 | |a 坦度螺酮 | |
| 650 | 4 | |a 老年 | |
| 650 | 4 | |a 冠心病 | |
| 650 | 4 | |a 焦虑抑郁障碍 | |
| 650 | 4 | |a Escitalopram | |
| 650 | 4 | |a tandospirone | |
| 650 | 4 | |a Elderly patients | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Coronary heart disease | |
| 650 | 4 | |a Anxiety and depression | |
| 700 | 0 | |a 魏鑫 |4 oth | |
| 700 | 0 | |a 郭聪 |4 oth | |
| 700 | 0 | |a 赵宾宾 |4 oth | |
| 700 | 0 | |a 胡琛 |4 oth | |
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