基于互信息算法的抗前列腺癌药物重定位分析 : = Prostate cancer drugs repositioning based on mutual information
药物重定位研究不仅大大减少了新药开发的周期,还降低了经济成本,越来越受到医药界的重视。前列腺癌是世界上死亡率较高的癌症,近年来针对单个基因的研究不足以分析癌症的复杂发病机理。首先,应用R软件的互信息方法分析前列腺癌的基因表达数据并提取前列腺癌特征基因,得到从失联到关联状态下含有大量致病基因信息的特征基因。然后,通过cmap分析确定了几种治疗前列腺癌的药物。使用的基因表达数据来自TCGA,通过互信息分析算法发现了294条上调基因和362条下调基因。对这些特征基因进行cmap分析,发现了多种化合物对前列腺癌具有抑制作用,通过cmap负相关分数降序排列,得到了Thioridazine(硫利达嗪)、trichostatin A(曲古菌素A)等更可能对前列腺癌有抑制作用的药物。.
The study of Drug Repositioning not only greatly reduces the cycle of new drug development, but also reduces the economic cost. Prostate cancer is one of the cancers with high mortality in the world. In recent years,the single gene can not explain the pathogenesis of the cancers. In this paper, the mutual information method in R software was mainly used to analyze the gene expression data of prostate cancer and select the feature genes of prostate cancer, so as to obtain the feature genes which containing a large amount of pathogenic gene information from the state of disconnection to association. Then several drugs for prostate cancer were identified by cmap analysis. The gene expression data used in this paper were from TCGA, and 294 up genes and 362 down genes were found through mutual information analysis. Though the connectivity map analyzes these feature genes, then find that a variety of compounds has inhibitory effects on prostate cancer. Through connectivity map negative correlation fraction descending order, Thioridazine, trichostatin A and other drugs are more likely to have inhibitory effects on prostate cancer were obtained..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019-02-15 2019 |
|---|---|
| Erschienen: |
2019-02-15 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2019 |
|---|---|
| Enthalten in: |
Chen yang shi fan da xue xue bao. Zi ran ke xue ban - (2019), 01 vom: 15. Feb., Seite 34-37 Original Letters: Enthalten in 沈阳师范大学学报. 自然科学版 (DE-600)2989172-3 (DE-600)2989172-3 辽宁省沈阳市 |
| Reihe: |
China Academic Journals (CAJ), A, 理工A(数学物理力学天地生) = Mathematics/ Physics/ Mechanics/ Astronomy China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
|---|
| Sprache: |
Chinesisch |
|---|
| Weiterer Titel: |
Prostate cancer drugs repositioning based on mutual information |
|---|
| Beteiligte Personen: |
|---|
| Links: |
oversea.cnki.net [lizenzpflichtig] |
|---|
| Anmerkungen: |
Author info:YANG Guang;HAO Yifan;College of Mathematics and Systems Science, Shenyang Normal University |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
CAJ625769848 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | CAJ625769848 | ||
| 003 | DE-627 | ||
| 005 | 20230120051015.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230102s2019 cc |||||o 00| ||chi c | ||
| 035 | |a (DE-627)CAJ625769848 | ||
| 035 | |a (SBB-XA)CAJ_SYSX201901007 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a chi | ||
| 044 | |c XB-CN | ||
| 084 | |a ASIEN |q DE-1a |2 fid | ||
| 084 | |a R979.1 |2 clc | ||
| 100 | 0 | |a 杨光 |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a 基于互信息算法的抗前列腺癌药物重定位分析 |b = Prostate cancer drugs repositioning based on mutual information |
| 246 | 3 | 1 | |a Prostate cancer drugs repositioning based on mutual information |
| 264 | 1 | |c 2019-02-15 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 490 | 0 | |a China Academic Journals (CAJ) |a A |a 理工A(数学物理力学天地生) = Mathematics/ Physics/ Mechanics/ Astronomy | |
| 490 | 0 | |a China Academic Journals (CAJ) |a E |a 医药卫生科技 = Medicine & Public Health | |
| 500 | |a Author info:YANG Guang;HAO Yifan;College of Mathematics and Systems Science, Shenyang Normal University | ||
| 520 | |a 药物重定位研究不仅大大减少了新药开发的周期,还降低了经济成本,越来越受到医药界的重视。前列腺癌是世界上死亡率较高的癌症,近年来针对单个基因的研究不足以分析癌症的复杂发病机理。首先,应用R软件的互信息方法分析前列腺癌的基因表达数据并提取前列腺癌特征基因,得到从失联到关联状态下含有大量致病基因信息的特征基因。然后,通过cmap分析确定了几种治疗前列腺癌的药物。使用的基因表达数据来自TCGA,通过互信息分析算法发现了294条上调基因和362条下调基因。对这些特征基因进行cmap分析,发现了多种化合物对前列腺癌具有抑制作用,通过cmap负相关分数降序排列,得到了Thioridazine(硫利达嗪)、trichostatin A(曲古菌素A)等更可能对前列腺癌有抑制作用的药物。 | ||
| 520 | |a The study of Drug Repositioning not only greatly reduces the cycle of new drug development, but also reduces the economic cost. Prostate cancer is one of the cancers with high mortality in the world. In recent years,the single gene can not explain the pathogenesis of the cancers. In this paper, the mutual information method in R software was mainly used to analyze the gene expression data of prostate cancer and select the feature genes of prostate cancer, so as to obtain the feature genes which containing a large amount of pathogenic gene information from the state of disconnection to association. Then several drugs for prostate cancer were identified by cmap analysis. The gene expression data used in this paper were from TCGA, and 294 up genes and 362 down genes were found through mutual information analysis. Though the connectivity map analyzes these feature genes, then find that a variety of compounds has inhibitory effects on prostate cancer. Through connectivity map negative correlation fraction descending order, Thioridazine, trichostatin A and other drugs are more likely to have inhibitory effects on prostate cancer were obtained. | ||
| 610 | 2 | 4 | |a 沈阳师范大学数学与系统科学学院 |
| 650 | 4 | |a 药学 | |
| 650 | 4 | |a 医药、卫生 | |
| 650 | 4 | |a Pharmaceutics | |
| 650 | 4 | |a 理工A(数学物理力学天地生) | |
| 650 | 4 | |a Mathematics/ Physics/ Mechanics/ Astronomy | |
| 650 | 4 | |a 医药卫生科技 | |
| 650 | 4 | |a Medicine & Public Health | |
| 650 | 4 | |a 药物重定位 | |
| 650 | 4 | |a 前列腺癌 | |
| 650 | 4 | |a 互信息 | |
| 650 | 4 | |a connectivity map | |
| 650 | 4 | |a drug repositioning | |
| 650 | 4 | |a prostate cancer | |
| 650 | 4 | |a mutual information | |
| 700 | 0 | |a 郝逸凡 |4 oth | |
| 773 | 0 | 8 | |6 880-01 |i Enthalten in |t Chen yang shi fan da xue xue bao. Zi ran ke xue ban |d Liao ning sheng chen yang shi, 1995 |g (2019), 01 vom: 15. Feb., Seite 34-37 |h Online-Ressource |w (DE-627)CAJ105749974 |w (DE-600)2989172-3 |7 nnns |
| 773 | 1 | 8 | |g year:2019 |g number:01 |g day:15 |g month:02 |g pages:34-37 |
| 856 | 4 | 0 | |u http://erf.sbb.spk-berlin.de/han/caj/oversea.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&filename=SYSX201901007 |x Verlag |y CrossAsia Link |z Deutschlandweit zugänglich |
| 856 | 4 | 0 | |u https://oversea.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&filename=SYSX201901007 |x Verlag |z lizenzpflichtig |
| 880 | 0 | 8 | |6 773-01/Hans |i Enthalten in |t 沈阳师范大学学报. 自然科学版 |d 辽宁省沈阳市 |h Online-Ressource |w (DE-627)CAJ105749974 |w (DE-600)2989172-3 |7 nnns |
| 912 | |a ZDB-1-CAJ | ||
| 912 | |a GBV_NL_CAJ | ||
| 912 | |a FID-ASIEN | ||
| 912 | |a SSG-OLC-OA3.1 | ||
| 912 | |a SSG-OLC-CAJ | ||
| 936 | u | w | |j 2019 |e 01 |b 15 |c 02 |h 34-37 |
| 951 | |a AR | ||
| 952 | |j 2019 |e 01 |b 15 |c 02 |h 34-37 | ||
| 980 | |2 11 |1 01 |x 0001 |b 645274976 |c 00 |f 5:FIDXASIA |d --%%-- |e --%%-- |j --%%-- |y k |z 02-01-23 | ||
| 981 | |2 11 |1 01 |x 0001 |r http://erf.sbb.spk-berlin.de/han/caj/oversea.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&filename=SYSX201901007 | ||