不同功能残气量对可吸入颗粒物在人体肺腺泡区沉积影响的实验研究 : = Experimental research on the effect of functional residual capacity on the deposition of inhalable particles in human alveoli region
研究可吸入颗粒物在肺腺泡内的沉积规律对于明确肺气肿等常见呼吸系统疾病的诱因和发展,以及优化临床治疗和预防方案具有重要意义。本文建立了能够模拟终末细支气管和肺腺泡颗粒物沉积的体外实验模型,在不同功能残气量模式下研究了不同粒径的可吸入颗粒物在肺腺泡内的沉积率。结果表明,颗粒物直径是影响颗粒物在肺腺泡沉积的重要因素,1μm左右的颗粒物沉积率最高。功能残气量增大,颗粒物沉积率显著降低。本文研究结果为肺气肿和尘肺等疾病的靶向吸入治疗提供了数据支撑和优化途径,建立的模型也为研究可吸入颗粒物在肺腺泡内的沉积规律提供了一种可行的体外实验模型。.
Research on the deposition of inhalable particles in the alveoli of the lungs is important to the causes,development for common respiratory diseases such as emphysema, and even the optimization of clinical treatment and prevention programs of them. In this paper, an in vitro experimental model was established to simulate the deposition of terminal bronchioles and pulmonary acinus particles. The deposition rate of inhalable particles with different particle sizes in the pulmonary acinus was studied under different functional residual capacity. The results showed that the particle diameter was an important factor affecting the deposition of particles in the lung alveoli. Particles with 1 μm diameter had the highest deposition rate. With the functional residual capacity increasing, particulate deposition rate significantly reduced. The results of this study may provide data support and optimization strategy for target inhalation therapy of respiratory diseases such as emphysema and pneumoconiosis. The established model may also provide a feasible in vitro experimental model for studying the deposition of inhalable particles in the pulmonary alveoli..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018-08-25 2018 |
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| Erschienen: |
2018-08-25 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2018 |
|---|---|
| Enthalten in: |
Sheng wu yi xue gong cheng xue za zhi - (2018), 04 vom: 25. Aug., Seite 557-563 Original Letters: Enthalten in 生物医学工程学杂志 (DE-600)2994928-2 (DE-600)2994928-2 四川省成都市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Experimental research on the effect of functional residual capacity on the deposition of inhalable particles in human alveoli region |
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| Beteiligte Personen: |
李蓉 [VerfasserIn] |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Anmerkungen: |
Author info:LI Rong;XU Xinxi;QIAO Yang;ZHAO Xiuguo;Institute of Medical Support Technology, Academy of Military Sciences;Department of Military Protective Medicine, Logistics University of Chinese People's Armed Police Force |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ602471583 |
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| 245 | 1 | 0 | |a 不同功能残气量对可吸入颗粒物在人体肺腺泡区沉积影响的实验研究 |b = Experimental research on the effect of functional residual capacity on the deposition of inhalable particles in human alveoli region |
| 246 | 3 | 1 | |a Experimental research on the effect of functional residual capacity on the deposition of inhalable particles in human alveoli region |
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| 500 | |a Author info:LI Rong;XU Xinxi;QIAO Yang;ZHAO Xiuguo;Institute of Medical Support Technology, Academy of Military Sciences;Department of Military Protective Medicine, Logistics University of Chinese People's Armed Police Force | ||
| 520 | |a 研究可吸入颗粒物在肺腺泡内的沉积规律对于明确肺气肿等常见呼吸系统疾病的诱因和发展,以及优化临床治疗和预防方案具有重要意义。本文建立了能够模拟终末细支气管和肺腺泡颗粒物沉积的体外实验模型,在不同功能残气量模式下研究了不同粒径的可吸入颗粒物在肺腺泡内的沉积率。结果表明,颗粒物直径是影响颗粒物在肺腺泡沉积的重要因素,1μm左右的颗粒物沉积率最高。功能残气量增大,颗粒物沉积率显著降低。本文研究结果为肺气肿和尘肺等疾病的靶向吸入治疗提供了数据支撑和优化途径,建立的模型也为研究可吸入颗粒物在肺腺泡内的沉积规律提供了一种可行的体外实验模型。 | ||
| 520 | |a Research on the deposition of inhalable particles in the alveoli of the lungs is important to the causes,development for common respiratory diseases such as emphysema, and even the optimization of clinical treatment and prevention programs of them. In this paper, an in vitro experimental model was established to simulate the deposition of terminal bronchioles and pulmonary acinus particles. The deposition rate of inhalable particles with different particle sizes in the pulmonary acinus was studied under different functional residual capacity. The results showed that the particle diameter was an important factor affecting the deposition of particles in the lung alveoli. Particles with 1 μm diameter had the highest deposition rate. With the functional residual capacity increasing, particulate deposition rate significantly reduced. The results of this study may provide data support and optimization strategy for target inhalation therapy of respiratory diseases such as emphysema and pneumoconiosis. The established model may also provide a feasible in vitro experimental model for studying the deposition of inhalable particles in the pulmonary alveoli. | ||
| 610 | 2 | 4 | |a 军事科学院系统工程研究院卫勤保障技术研究所 |
| 610 | 2 | 4 | |a 武警后勤学院防护医学教研室 |
| 650 | 4 | |a 环境卫生、环境医学 | |
| 650 | 4 | |a 预防医学、卫生学 | |
| 650 | 4 | |a 医药、卫生 | |
| 650 | 4 | |a Environment Science and Resources Utilization | |
| 650 | 4 | |a Preventive Medicine and Hygiene | |
| 650 | 4 | |a 医药卫生科技 | |
| 650 | 4 | |a Medicine & Public Health | |
| 650 | 4 | |a 理工B(化学化工冶金环境矿业) | |
| 650 | 4 | |a Chemistry/ Metallurgy/ Environment/ Mine Industry | |
| 650 | 4 | |a 肺腺泡 | |
| 650 | 4 | |a 可吸入颗粒物 | |
| 650 | 4 | |a 沉积 | |
| 650 | 4 | |a 功能残气量 | |
| 650 | 4 | |a pulmonary alveoli | |
| 650 | 4 | |a inhalable particle | |
| 650 | 4 | |a deposition | |
| 650 | 4 | |a functional residual capacity | |
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