口腔牙托水对大鼠细胞色素P450酶活性的影响 : = Effects of methyl methacrylate on CYP450 in rats
目的研究牙托水对大鼠CYP1A2、CYP2B6和CYP2C19酶活性的影响。方法 24只雄性SD大鼠,随机分为正常对照组、灌胃牙托水3 d组、灌胃牙托水10 d组。牙托水干预结束后,各组大鼠联合灌胃给予非那西丁10 mg/kg、安非他酮10 mg/kg和奥美拉唑10 mg/kg并测定探针药给予前及给药后的0.083 h、0.25 h、0.5 h、1 h、1.5 h、2 h、2.5 h、3 h、4 h、6 h、8 h、12 h和24 h的血药浓度。结果与正常对照组相比,10 d组大鼠奥美拉唑AUC下降;清除率CL/F显著性升高;平均驻留时间MRT下降;10 d组大鼠安非他酮表观分布体积V/F显著性降低,上述差异均有统计学意义(P<0.05);探针药的其余药代参数差异均无统计学意义(P>0.05)。结论牙托水可诱导肝CYP2C19酶活性,而对CYP1A2与CYP2B6无影响。.
Objective To elucidate the effects of methyl methacrylate on CYP1 A2,CYP2 B6 and CYP2 C19 in rats. Methods 24 male SD rats were randomly divided into 3 groups: Control group,MMA-3 d group and MMA-10 d group. All rats of three groups were administered intragastrically with 10 mg/kg phenacetin,10 mg/kg bupropion and 10 mg/kg omeprazole after administration of MMA for 3 or 10 consecutive days. Then,the blood samples were collected for analysis at 0,0. 083,0. 25,0. 5,1,1. 5,2,2. 5,3,4,6,8,12 and 24 h after administration. Results Compared with the normal control group,the omeprazole AUC decreased in the 10 d group; the clearance rate of CL/F increased significantly; the mean residence time of MRT decreased; the apparent distribution volume of bupropion( V/F) in the 10 d group significantly decreased,and the above differences were statistically significant( P < 0. 05). There were no statistical significance on the differences in the remaining pharmacokinetic parameters of the probe( P > 0. 05). Conclusion The results maybe indicated that MMA had the potential to induce rat hepatic CYP2 C19 activity,but not CYP1 A2 and CYP2 B6..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018-07-25 2018 |
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| Erschienen: |
2018-07-25 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2018 |
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| Enthalten in: |
Zhong guo wei sheng jian yan za zhi - (2018), 14 vom: 25. Juli, Seite 1689-1692 Original Letters: Enthalten in 中国卫生检验杂志 (DE-600)2993271-3 (DE-600)2993271-3 北京市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Effects of methyl methacrylate on CYP450 in rats |
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| Beteiligte Personen: |
程晶晶 [VerfasserIn] |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Anmerkungen: |
Author info:CHENG Jing-jing;ZHANG Yang;WU Shi-pian;SUN Ke-yuan;ZHAO Shu-yue;ZHU Jia-yin;Stomatological Hospital Affiliated to School of Stomatology,Wenzhou Medical University |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ601174151 |
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| 245 | 1 | 0 | |a 口腔牙托水对大鼠细胞色素P450酶活性的影响 |b = Effects of methyl methacrylate on CYP450 in rats |
| 246 | 3 | 1 | |a Effects of methyl methacrylate on CYP450 in rats |
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| 520 | |a 目的研究牙托水对大鼠CYP1A2、CYP2B6和CYP2C19酶活性的影响。方法 24只雄性SD大鼠,随机分为正常对照组、灌胃牙托水3 d组、灌胃牙托水10 d组。牙托水干预结束后,各组大鼠联合灌胃给予非那西丁10 mg/kg、安非他酮10 mg/kg和奥美拉唑10 mg/kg并测定探针药给予前及给药后的0.083 h、0.25 h、0.5 h、1 h、1.5 h、2 h、2.5 h、3 h、4 h、6 h、8 h、12 h和24 h的血药浓度。结果与正常对照组相比,10 d组大鼠奥美拉唑AUC下降;清除率CL/F显著性升高;平均驻留时间MRT下降;10 d组大鼠安非他酮表观分布体积V/F显著性降低,上述差异均有统计学意义(P<0.05);探针药的其余药代参数差异均无统计学意义(P>0.05)。结论牙托水可诱导肝CYP2C19酶活性,而对CYP1A2与CYP2B6无影响。 | ||
| 520 | |a Objective To elucidate the effects of methyl methacrylate on CYP1 A2,CYP2 B6 and CYP2 C19 in rats. Methods 24 male SD rats were randomly divided into 3 groups: Control group,MMA-3 d group and MMA-10 d group. All rats of three groups were administered intragastrically with 10 mg/kg phenacetin,10 mg/kg bupropion and 10 mg/kg omeprazole after administration of MMA for 3 or 10 consecutive days. Then,the blood samples were collected for analysis at 0,0. 083,0. 25,0. 5,1,1. 5,2,2. 5,3,4,6,8,12 and 24 h after administration. Results Compared with the normal control group,the omeprazole AUC decreased in the 10 d group; the clearance rate of CL/F increased significantly; the mean residence time of MRT decreased; the apparent distribution volume of bupropion( V/F) in the 10 d group significantly decreased,and the above differences were statistically significant( P < 0. 05). There were no statistical significance on the differences in the remaining pharmacokinetic parameters of the probe( P > 0. 05). Conclusion The results maybe indicated that MMA had the potential to induce rat hepatic CYP2 C19 activity,but not CYP1 A2 and CYP2 B6. | ||
| 610 | 2 | 4 | |a 温州医科大学口腔医学院附属口腔医院 |
| 610 | 2 | 4 | |a 温州医科大学仁济学院 |
| 610 | 2 | 4 | |a 温州医科大学实验动物中心 |
| 650 | 4 | |a 口腔矫形学 | |
| 650 | 4 | |a 口腔科学 | |
| 650 | 4 | |a 医药、卫生 | |
| 650 | 4 | |a Stomatology | |
| 650 | 4 | |a Biomedicine Engineering | |
| 650 | 4 | |a 医药卫生科技 | |
| 650 | 4 | |a Medicine & Public Health | |
| 650 | 4 | |a 探针药 | |
| 650 | 4 | |a 牙托水 | |
| 650 | 4 | |a 药动学 | |
| 650 | 4 | |a 细胞色素P450酶 | |
| 650 | 4 | |a Probe drug | |
| 650 | 4 | |a Dental care water | |
| 650 | 4 | |a Pharmacokinetics | |
| 650 | 4 | |a Cytochrome P450 enzyme | |
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| 700 | 0 | |a 赵舒悦 |4 oth | |
| 700 | 0 | |a 朱加银 |4 oth | |
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