网络药理学在中药药物重定位研究中的应用现状与思考 : = Network pharmacology in drug repositioning of Chinese medicines:application status and thinking
药物重定位(又称老药新用)是指已上市药物发现新适应症或新用途,其不仅在西药研发中受到越来越多的关注,在中药新药研究领域也逐渐成为热门。目前,药物重定位研究已进入基于计算机技术的新阶段,其研究方法、技术得到不断地完善。网络药理学方法在药物重定位研究方面发挥着越来越重要的作用,目前其应用于中药药物重定位研究中的策略主要包括基于小分子(或配体)、基于药物靶点和基于网络理论三方面。本文对中药药物重定位的概念、研究现状及网络药理学的应用现状及策略进行介绍,以期为中药药物重定位研究提供参考。.
Drug repositioning, also known as conventional drug in novel use, is the discovery of new indications or novel use of the drug. It has received more and more attention not only in the research and development of western medicine, but also gradually become popular in the research field of Chinese medicine. The new phase of drug repositioning research is based on computer technology, and its research methods and techniques keep up with the time.Network pharmacology is playing more and more important role in the study of drug repositioning. At present, the strategies used in the study of traditional Chinese medicine repositioning include small molecules(or ligands), drug targets and network theory. In this paper, the concept, research status, application status of Chinese medicinals repositioning and application status and strategy of network pharmacology are reviewed, in order to provide references for the study of drug repositioning in Chinese medicinal..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017-11-25 2017 |
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| Erschienen: |
2017-11-25 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2017 |
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| Enthalten in: |
Zhong guo xun zheng yi xue za zhi - (2017), 11 vom: 25. Nov., Seite 1344-1349 Original Letters: Enthalten in 中国循证医学杂志 (DE-600)2989286-7 (DE-600)2989286-7 四川省成都市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Network pharmacology in drug repositioning of Chinese medicines:application status and thinking |
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| Beteiligte Personen: |
刘艳飞 [VerfasserIn] |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Anmerkungen: |
Author info:LIU Yanfei;SUN Mingyue;ZHAO Yingke;YAO Hezhi;LIU Yue;GAO Rui;Graduate School of Beijing University of Chinese Medicine;Institute of Clinical Pharmacology of Xiyuan Hospital,China Academy of Chinese Medical Sciences;School of Chinese Medicine,the University of Hong Kong;Cardiovascular Diseases Center,Xiyuan Hospital of China Academy of Chinese Medical Sciences |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ577181440 |
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| 245 | 1 | 0 | |a 网络药理学在中药药物重定位研究中的应用现状与思考 |b = Network pharmacology in drug repositioning of Chinese medicines:application status and thinking |
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| 520 | |a 药物重定位(又称老药新用)是指已上市药物发现新适应症或新用途,其不仅在西药研发中受到越来越多的关注,在中药新药研究领域也逐渐成为热门。目前,药物重定位研究已进入基于计算机技术的新阶段,其研究方法、技术得到不断地完善。网络药理学方法在药物重定位研究方面发挥着越来越重要的作用,目前其应用于中药药物重定位研究中的策略主要包括基于小分子(或配体)、基于药物靶点和基于网络理论三方面。本文对中药药物重定位的概念、研究现状及网络药理学的应用现状及策略进行介绍,以期为中药药物重定位研究提供参考。 | ||
| 520 | |a Drug repositioning, also known as conventional drug in novel use, is the discovery of new indications or novel use of the drug. It has received more and more attention not only in the research and development of western medicine, but also gradually become popular in the research field of Chinese medicine. The new phase of drug repositioning research is based on computer technology, and its research methods and techniques keep up with the time.Network pharmacology is playing more and more important role in the study of drug repositioning. At present, the strategies used in the study of traditional Chinese medicine repositioning include small molecules(or ligands), drug targets and network theory. In this paper, the concept, research status, application status of Chinese medicinals repositioning and application status and strategy of network pharmacology are reviewed, in order to provide references for the study of drug repositioning in Chinese medicinal. | ||
| 610 | 2 | 4 | |a 北京中医药大学研究生院 |
| 610 | 2 | 4 | |a 中国中医科学院西苑医院临床药理研究所 |
| 610 | 2 | 4 | |a 香港大学医学院中医药学院 |
| 610 | 2 | 4 | |a 中国中医科学院西苑医院心血管病中心 |
| 650 | 4 | |a 中药学、方剂学 | |
| 650 | 4 | |a 中医 | |
| 650 | 4 | |a 医药、卫生 | |
| 650 | 4 | |a Traditional Chinese Medicinal Herbs | |
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| 650 | 4 | |a 药物重定位 | |
| 650 | 4 | |a 中药 | |
| 650 | 4 | |a 网络药理学 | |
| 650 | 4 | |a 老药新用 | |
| 650 | 4 | |a Drug repositioning | |
| 650 | 4 | |a Chinese medicinals | |
| 650 | 4 | |a Network pharmacology | |
| 650 | 4 | |a Conventional drug in new use | |
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| 700 | 0 | |a 赵莹科 |4 oth | |
| 700 | 0 | |a 姚贺之 |4 oth | |
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