原发性局灶节段性肾小球硬化与通透性因子的研究进展 : = Circulating Permeability Factors in Primary Focal Segmental Glomerulosclerosis: A Review of the Literature
原发性局灶节段性肾小球硬化(FSGS)是激素耐药型肾病综合征的主要病理类型之一,耐药性的FSGS预后较差,大部分将进展至终末期肾病,需要透析或肾脏移植。近年来,有临床观察提出FSGS患者体内可能存在一种与大量蛋白发生相关的循环因子,随后在动物实验以及体外观察证实了循环因子的存在。目前已提出心肌营养素样因子1、抗CD_(40)抗体以及可溶性尿激酶型纤溶酶原激活受体(suPAR)是潜在的循环因子,但确切的证据还有待发现。其中suPAR也可能是作为诊断原发性FSGS的生物标志物。.
Primary focal periodic glomerular sclerosis( FSGS) is one of the main pathological types of steroid-resistant nephrotic syndrome,and the prognosis of patients with steroid-resistant FSGS is poor. Most of the patients will progress to end-stage renal disease which needs dialysis or kidney transplantation. It has been speculated that some circulating permeability factors have relationship with the pathogenesis of the disease by researchers in recent years,such as cardiotrophin-like cytokine 1,CD_(40) antibodies and soluble urokinase-type plasminogen activator receptor( su PAR),but the definite proof still needs to be discovered. The su PAR might be used as a diagnostic biomarker of primary FSGS..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017-09-05 2017 |
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| Erschienen: |
2017-09-05 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2017 |
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| Enthalten in: |
Yi xue zong shu - (2017), 17 vom: 05. Sept., Seite 3445-3449 Original Letters: Enthalten in 医学综述 (DE-600)2992477-7 (DE-600)2992477-7 天津市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Circulating Permeability Factors in Primary Focal Segmental Glomerulosclerosis: A Review of the Literature |
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| Beteiligte Personen: |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Anmerkungen: |
Author info:LIU Xi;ZHANG Ying;CHEN Xiaoli;Internal Medicine Department Five,Chongqing City Yubei District People's Hospital |
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| Förderinstitution / Projekttitel: |
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| 520 | |a 原发性局灶节段性肾小球硬化(FSGS)是激素耐药型肾病综合征的主要病理类型之一,耐药性的FSGS预后较差,大部分将进展至终末期肾病,需要透析或肾脏移植。近年来,有临床观察提出FSGS患者体内可能存在一种与大量蛋白发生相关的循环因子,随后在动物实验以及体外观察证实了循环因子的存在。目前已提出心肌营养素样因子1、抗CD_(40)抗体以及可溶性尿激酶型纤溶酶原激活受体(suPAR)是潜在的循环因子,但确切的证据还有待发现。其中suPAR也可能是作为诊断原发性FSGS的生物标志物。 | ||
| 520 | |a Primary focal periodic glomerular sclerosis( FSGS) is one of the main pathological types of steroid-resistant nephrotic syndrome,and the prognosis of patients with steroid-resistant FSGS is poor. Most of the patients will progress to end-stage renal disease which needs dialysis or kidney transplantation. It has been speculated that some circulating permeability factors have relationship with the pathogenesis of the disease by researchers in recent years,such as cardiotrophin-like cytokine 1,CD_(40) antibodies and soluble urokinase-type plasminogen activator receptor( su PAR),but the definite proof still needs to be discovered. The su PAR might be used as a diagnostic biomarker of primary FSGS. | ||
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