Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice : = Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice
AIM: To investigate the effects of Clostridium butyricum(C. butyricum) on experimental gastric ulcers(GUs) induced by alcohol, restraint cold stress, or pyloric ligation in mice, respectively.METHODS: One hundred and twenty mice were randomly allocated into three types of gastric ulcer models(n = 40 each), induced by alcohol, restraint cold stress, or pyloric ligation. In each GU model, 40 mice were allocated into four groups(n = 10 each): the sham control group; model group(GU induction without pretreatment); C. butyricum group(GU induction with C. butyricum pretreatment); and Omeprazole group(GU induction with Omeprazole pretreatment). Theeffects of C. butyricum were evaluated by examining the histological changes in the gastric mucosal erosion area, the activities of superoxide dismutase(SOD) and catalase(CAT), the level of malondialdehyde(MDA), and the contents of interleukin(IL)-1b, tumor necrosis factor(TNF)-α, leukotriene B4(LTB4) and 6-keto-PGF-1α(degradation product of PGI2) in the gastric tissue.RESULTS: Our data showed that C. butyricum significantly reduced the gastric mucosal injury area and ameliorated the pathological conditions of the gastric mucosa. C. butyricum not only minimized the decreases in activity of SOD and CAT, but also reduced the level of MDA in all three GU models used in this study. The accumulation of IL1-b, TNF-α and LBT4 decreased, while 6-keto-PGF-1α increased with pretreatment by C. butyricum in all three GU models.CONCLUSION: Our data demonstrated the protective effects of pretreatment with C. butyricum on antioxidation and anti-inflammation in different types of GU models in mice. Further studies are needed to explore its potential clinical benefits..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015-07-21 2015 |
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| Erschienen: |
2015-07-21 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2015 |
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| Enthalten in: |
World Journal of Gastroenterology - (2015), 27 vom: 21. Juli, Seite 8340-8351 Original Letters: Enthalten in (DE-627)CAJ045429103 (DE-627)CAJ045429103 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice |
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| Beteiligte Personen: |
Fang-Yan Wang [VerfasserIn] |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Anmerkungen: |
Author info:Fang-Yan Wang;Jia-Ming Liu;Hai-Hua Luo;Ai-Hua Liu;Yong Jiang;State Key Laboratory of Organ Failure Research, Nanfang Hospital;Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Key Laboratory of Proteomics of Guangdong Province;Department of Pathophysiology, Southern Medical University;Department of Pathophysiology, Wenzhou Medical University;School of Environmental Science and Public Health, Wenzhou Medical University |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ485057786 |
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| 520 | |a AIM: To investigate the effects of Clostridium butyricum(C. butyricum) on experimental gastric ulcers(GUs) induced by alcohol, restraint cold stress, or pyloric ligation in mice, respectively.METHODS: One hundred and twenty mice were randomly allocated into three types of gastric ulcer models(n = 40 each), induced by alcohol, restraint cold stress, or pyloric ligation. In each GU model, 40 mice were allocated into four groups(n = 10 each): the sham control group; model group(GU induction without pretreatment); C. butyricum group(GU induction with C. butyricum pretreatment); and Omeprazole group(GU induction with Omeprazole pretreatment). Theeffects of C. butyricum were evaluated by examining the histological changes in the gastric mucosal erosion area, the activities of superoxide dismutase(SOD) and catalase(CAT), the level of malondialdehyde(MDA), and the contents of interleukin(IL)-1b, tumor necrosis factor(TNF)-α, leukotriene B4(LTB4) and 6-keto-PGF-1α(degradation product of PGI2) in the gastric tissue.RESULTS: Our data showed that C. butyricum significantly reduced the gastric mucosal injury area and ameliorated the pathological conditions of the gastric mucosa. C. butyricum not only minimized the decreases in activity of SOD and CAT, but also reduced the level of MDA in all three GU models used in this study. The accumulation of IL1-b, TNF-α and LBT4 decreased, while 6-keto-PGF-1α increased with pretreatment by C. butyricum in all three GU models.CONCLUSION: Our data demonstrated the protective effects of pretreatment with C. butyricum on antioxidation and anti-inflammation in different types of GU models in mice. Further studies are needed to explore its potential clinical benefits. | ||
| 610 | 2 | 4 | |a State Key Laboratory of Organ Failure Research, Nanfang Hospital |
| 610 | 2 | 4 | |a Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Key Laboratory of Proteomics of Guangdong Province |
| 610 | 2 | 4 | |a Department of Pathophysiology, Southern Medical University |
| 610 | 2 | 4 | |a Department of Pathophysiology, Wenzhou Medical University |
| 610 | 2 | 4 | |a School of Environmental Science and Public Health, Wenzhou Medical University |
| 650 | 4 | |a 消化系及腹部疾病 | |
| 650 | 4 | |a 内科学 | |
| 650 | 4 | |a 医药、卫生 | |
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| 700 | 0 | |a Hai-Hua Luo |4 oth | |
| 700 | 0 | |a Ai-Hua Liu |4 oth | |
| 700 | 0 | |a Yong Jiang |4 oth | |
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