大麻酚类受体拮抗剂SR141716A减少乙醇蒸气室中大鼠的自发反应性乙醇自身给药行为(英文) : = Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers
ABM: To study the potential role of dependence status on CB1-mediated blockade of ethanol self-administration. METHODS: We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg/kg) on operant ethanol (10 % v/v) self-administration in male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical vapor chambers. RESULTS: Dependent animals responded more for ethanol than did air control nondependent rats. The acute administration of a 3 mg/kg dose of SR141716A almost suppressed ethanol self-administration only in ethanol dependent animals. However, operant responses for food were not affected by the administration of SR141716A. CONCLUSION: These results further support that cannabinoid CB1 receptor blockade may have a potential utility for the treatment of alcoholism..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
1999-12-15 1999 |
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| Erschienen: |
1999-12-15 |
| Enthalten in: |
Zur Gesamtaufnahme - year:1999 |
|---|---|
| Enthalten in: |
Acta Pharmacologica Sinica - (1999), 12 vom: 15. Dez., Seite 55-60 Original Letters: Enthalten in (DE-600)2997713-7 (DE-600)2997713-7 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Englisch |
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| Weiterer Titel: |
Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers |
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| Beteiligte Personen: |
FONSECA, Feinando RODRIGUEZ DE [VerfasserIn] |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Umfang: |
6 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ242470807 |
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| 245 | 1 | 0 | |a 大麻酚类受体拮抗剂SR141716A减少乙醇蒸气室中大鼠的自发反应性乙醇自身给药行为(英文) |b = Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers |
| 246 | 3 | 1 | |a Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers |
| 264 | 1 | |c 1999-12-15 | |
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| 520 | |a ABM: To study the potential role of dependence status on CB1-mediated blockade of ethanol self-administration. METHODS: We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg/kg) on operant ethanol (10 % v/v) self-administration in male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical vapor chambers. RESULTS: Dependent animals responded more for ethanol than did air control nondependent rats. The acute administration of a 3 mg/kg dose of SR141716A almost suppressed ethanol self-administration only in ethanol dependent animals. However, operant responses for food were not affected by the administration of SR141716A. CONCLUSION: These results further support that cannabinoid CB1 receptor blockade may have a potential utility for the treatment of alcoholism. | ||
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