检测特异性抗体用于日本血吸虫病疗效考核的研究 : = STUDIES ON THE DETECTION OF SPECIFIC CIRCULATING ANTIBODIES AND ITS VALUE OF INDICATING THE EFFECT OF CHEMOTHERAPY IN SCHISTOSOMIASIS
In order to understand the value of specific IgG and its subclasses in indicating treatment effect, we used both soluble egg antigens(SEA) and adult worm antigens(AWA) of Schistosoma japonicum to measure the specific IgG and IgG1/IgG4 in 264 serum samples of patients with schistosomiasis before and after chemotherapy by using ELISA. The control sera(50 samples) came from normal persons who did not live in endemic areas and were confirmed by negative stool examination. The result showed that the anti egg circulating antibodies(CAb) in sera of the patients infected with S. japonicum disappeared more quickly than anti adult worm antibodies after therapy. Anti SEA IgG and IgG4 both had significant decline in 3 months after treatment and became normal in 12 months after therapy. All of the anti adult worm antibodies didnt have a significant decline till 6 months after chemotherapy, and only anti AWA IgG4 fell to normal in 12 months after treatment. The negative conversion rates of anti SEA IgG4 and anti AWA IgG4 were the same and also the highest(97.7%) in 12 months after therapy. The negative conversion rate of anti SEA IgG was the second(75%). Both IgG and IgG4 anti SEA descended more quickly than antibodies adult worms. The specific IgG4 was a short duration antibody which was able to indicate the effect of treatment in schistosomiasis japonica especially anti SEA IgG4. Key words\ Schistosomiasis, short duration antibody, IgG subclass瑁� ｃｏｎｔｉｎｕｏｕｓ ｌｉｇｈｔ ｅｘｐｏｓｕｒｅ，ｔｈｅ ｒｈｏｄｏｐｓｉｎ ｌｅｖｅｌｓ ｉｎ ｒａｔ ｒｅｔｉｎａｓ ｄｒｏｐｐｅｄ ｄｒａｍａｔｉｃａｌｌｙ ｗｉｔｈｉｎ ｔｈｅ ｆｒｉｓｔ １ ｏｒ ２ ｄａｙｓ，ｔｈｅｎ ｃｈａｎｇｅｄ ｓｌｏｗｌｙ．Ｉｎ ｃｅｒｔａｉｎ ｐｅｒｉｏｄ ｏｆ ｔｉｍｅ，ｔｈｅ ｌｏｎｇｅｒ ｌｉｇｈｔ ｅｘｐｏｓｕｒｅ ｗａｓ ｒｅｃｅｉｖｅｄ，ｔｈｅ ｌｏｗｅｒ ｒｈｏｄｏｐｓｉｎ ｌｅｖｅｌｓ ｉｎ ｒａｔ ｒｅｔｉｎａｓ ｗｅｒｅ ｒｅｃｏｒｅｄｅｄ．Ａｓ ｔｈｅ ｔｉｍｅ ｏｆ ｒｅｃｏｖｅｒｙ ｉｎ ｄａｒｋ ｉｎｃｒｅａｓｅｄ，ｔｈｅ ｒｈｏｄｏｐｓｉｎ ｌｅｖｅｌｓ ｇｒａｄｕａｌｌｙ ｉｎｃｒｅａｓｅｄ，ａｎｄ ｆｏｌｌｏｗｅｄ ａ ｄｒｏｐ ｉｎ ａｂｏｕｔ ｏｎｅ ｗｅｅｋ，ｔｈｅｎ ｃｏｎｔｉｎｕｅｄ ｔｏ ｉｎｃｒｅａｓｅ．Ｔｈｅ ｒｈｏｄｏｐｓｉｎ ｌｅｖｅｌｓ ｉｎ ｒａｔ ｒｅｔｉｎａｓ ｇｒｅａｔｌｙ ｄｅｃｒｅａｓｅｄ ａｆｔｅｒ ｃｏｎｔｉｎｕｏｕｓ ｅｘｐｏｓｕｒｅ ｔｏ ｌｉｇｈｔ，ａｎｄ ｔｈｅ ｔｉｍｅ ｏｆ ｌｉｇｈｔ ｅｘｐｏｓｕｒｅ ｃｌｏｓｅｌｙ ｃｏｒｒｅｌａｔｅｄ ｗｉｔｈ ｔｈｅ ｒｈｏｄｏｐｓｉｎ ｌｅｖｅｌｓ ｉｎ ｃｅｒｔａｉｎ ｐｅｒｉｏｄｅ ｏｆ ｔｉｍｅ．Ｉｔ ｉｓ ａ ｇｏｏｄ ｗａｙ ｔｏ ａｎａｌｙｚｅ ｔｈｅ ｒｈｏｄｏｐｓｉｎ ｌｅｖｅｌｓ ｉｎ ｒａｔ ｒｅｔｉｎａｓ ｓｉｍｐｌｙ ｂｙ ｓｐｅｃｔｒｏｐｈｏｔｏｍｅｔｅｒｙ．.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
1999-12-30 1999 |
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| Erschienen: |
1999-12-30 |
| Enthalten in: |
Zur Gesamtaufnahme - year:1999 |
|---|---|
| Enthalten in: |
Zhong guo bing yuan sheng wu xue za zhi - (1999), 4 vom: 30. Dez., Seite 69-71 Original Letters: Enthalten in 中国病原生物学杂志 (DE-600)2994321-8 (DE-600)2994321-8 山东省济宁市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
STUDIES ON THE DETECTION OF SPECIFIC CIRCULATING ANTIBODIES AND ITS VALUE OF INDICATING THE EFFECT OF CHEMOTHERAPY IN SCHISTOSOMIASIS |
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| Beteiligte Personen: |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Themen: |
内科学 |
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| Umfang: |
3 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ232905797 |
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| 245 | 1 | 0 | |a 检测特异性抗体用于日本血吸虫病疗效考核的研究 |b = STUDIES ON THE DETECTION OF SPECIFIC CIRCULATING ANTIBODIES AND ITS VALUE OF INDICATING THE EFFECT OF CHEMOTHERAPY IN SCHISTOSOMIASIS |
| 246 | 3 | 1 | |a STUDIES ON THE DETECTION OF SPECIFIC CIRCULATING ANTIBODIES AND ITS VALUE OF INDICATING THE EFFECT OF CHEMOTHERAPY IN SCHISTOSOMIASIS |
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| 520 | |a In order to understand the value of specific IgG and its subclasses in indicating treatment effect, we used both soluble egg antigens(SEA) and adult worm antigens(AWA) of Schistosoma japonicum to measure the specific IgG and IgG1/IgG4 in 264 serum samples of patients with schistosomiasis before and after chemotherapy by using ELISA. The control sera(50 samples) came from normal persons who did not live in endemic areas and were confirmed by negative stool examination. The result showed that the anti egg circulating antibodies(CAb) in sera of the patients infected with S. japonicum disappeared more quickly than anti adult worm antibodies after therapy. Anti SEA IgG and IgG4 both had significant decline in 3 months after treatment and became normal in 12 months after therapy. All of the anti adult worm antibodies didnt have a significant decline till 6 months after chemotherapy, and only anti AWA IgG4 fell to normal in 12 months after treatment. The negative conversion rates of anti SEA IgG4 and anti AWA IgG4 were the same and also the highest(97.7%) in 12 months after therapy. The negative conversion rate of anti SEA IgG was the second(75%). Both IgG and IgG4 anti SEA descended more quickly than antibodies adult worms. The specific IgG4 was a short duration antibody which was able to indicate the effect of treatment in schistosomiasis japonica especially anti SEA IgG4. Key words\ Schistosomiasis, short duration antibody, IgG subclass瑁� ｃｏｎｔｉｎｕｏｕｓ ｌｉｇｈｔ ｅｘｐｏｓｕｒｅ，ｔｈｅ ｒｈｏｄｏｐｓｉｎ ｌｅｖｅｌｓ ｉｎ ｒａｔ ｒｅｔｉｎａｓ ｄｒｏｐｐｅｄ ｄｒａｍａｔｉｃａｌｌｙ ｗｉｔｈｉｎ ｔｈｅ ｆｒｉｓｔ １ ｏｒ ２ ｄａｙｓ，ｔｈｅｎ ｃｈａｎｇｅｄ ｓｌｏｗｌｙ．Ｉｎ ｃｅｒｔａｉｎ ｐｅｒｉｏｄ ｏｆ ｔｉｍｅ，ｔｈｅ ｌｏｎｇｅｒ ｌｉｇｈｔ ｅｘｐｏｓｕｒｅ ｗａｓ ｒｅｃｅｉｖｅｄ，ｔｈｅ ｌｏｗｅｒ ｒｈｏｄｏｐｓｉｎ ｌｅｖｅｌｓ ｉｎ ｒａｔ ｒｅｔｉｎａｓ ｗｅｒｅ ｒｅｃｏｒｅｄｅｄ．Ａｓ ｔｈｅ ｔｉｍｅ ｏｆ ｒｅｃｏｖｅｒｙ ｉｎ ｄａｒｋ ｉｎｃｒｅａｓｅｄ，ｔｈｅ ｒｈｏｄｏｐｓｉｎ ｌｅｖｅｌｓ ｇｒａｄｕａｌｌｙ ｉｎｃｒｅａｓｅｄ，ａｎｄ ｆｏｌｌｏｗｅｄ ａ ｄｒｏｐ ｉｎ ａｂｏｕｔ ｏｎｅ ｗｅｅｋ，ｔｈｅｎ ｃｏｎｔｉｎｕｅｄ ｔｏ ｉｎｃｒｅａｓｅ．Ｔｈｅ ｒｈｏｄｏｐｓｉｎ ｌｅｖｅｌｓ ｉｎ ｒａｔ ｒｅｔｉｎａｓ ｇｒｅａｔｌｙ ｄｅｃｒｅａｓｅｄ ａｆｔｅｒ ｃｏｎｔｉｎｕｏｕｓ ｅｘｐｏｓｕｒｅ ｔｏ ｌｉｇｈｔ，ａｎｄ ｔｈｅ ｔｉｍｅ ｏｆ ｌｉｇｈｔ ｅｘｐｏｓｕｒｅ ｃｌｏｓｅｌｙ ｃｏｒｒｅｌａｔｅｄ ｗｉｔｈ ｔｈｅ ｒｈｏｄｏｐｓｉｎ ｌｅｖｅｌｓ ｉｎ ｃｅｒｔａｉｎ ｐｅｒｉｏｄｅ ｏｆ ｔｉｍｅ．Ｉｔ ｉｓ ａ ｇｏｏｄ ｗａｙ ｔｏ ａｎａｌｙｚｅ ｔｈｅ ｒｈｏｄｏｐｓｉｎ ｌｅｖｅｌｓ ｉｎ ｒａｔ ｒｅｔｉｎａｓ ｓｉｍｐｌｙ ｂｙ ｓｐｅｃｔｒｏｐｈｏｔｏｍｅｔｅｒｙ． | ||
| 610 | 2 | 4 | |a 广东医学院寄生虫学教研室 |
| 610 | 2 | 4 | |a 湛江 |
| 610 | 2 | 4 | |a 同济医科大学寄生虫学研究室 |
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| 650 | 4 | |a Medicine & Public Health | |
| 650 | 4 | |a 寄生虫病 | |
| 650 | 4 | |a 内科学 | |
| 650 | 4 | |a 医药、卫生 | |
| 650 | 4 | |a 日本血吸虫病 | |
| 650 | 4 | |a 短期抗体 | |
| 650 | 4 | |a IgG亚类 | |
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