SARS诊治新进展 : = Recent progress in the management of SARS in China
There were three events of SARS in the mainland of China from November 2002 to May 2004.Although a SARS pandemic broke out during the first event,it was circumvented during the latter two,due to establishment of strict policies and control measures.A study of molecular evolution of SARS-CoV during SARS-pandemic in the mainland showed that deletion of nucleotides in orf8 was closely associated with the infectivity and toxicity of SARS-CoV.Generally speaking,SARS-CoV was transmitted via droplets over a short distance.Under certain circumstance,as in the Amoy Garden,virus can spread via air-borne transmission.Some wildlife from Felidae Carnivora(flesh-eating animal of the cat family),like civet cats,were suspected as important reservoir in SARS-CoV transmission to human beings (Guan Y et al:Science 2003).By entering exotic food markets,these suspects have become the topmost link by far recognized in SARS transmission route as dangerous sources undermining the preventing of SARS.Early in the year of 2004,the Guangdong local government and Department of Public Health tokk strong actions regarding strict control of the wildlife market and `four earliness' to stop transmission from human to human.This control strategy seems to have effectively prevented the second SARS event from evolving into an outbreak.Studies have shown evidences of sub-clinical patients of SARS.Antigen detection targeting at N-protein of SARS-CoV has also shown benefit in confirming diagnosis within 7 days after onset.From a controlled study in Guangzhou,administreation of corticosteroids was associated with reduced mortality and shorter hospital stay in SARS patients with acute lung injury of ARDS.Clinical trials using inactivated whole SARS-CoV vaccine is currently in process.Results will be available at the beginning of next year.Researches on genotherapy using small interfering RNA(SiRNA) have also been initiated for the prevention and treatment of SARS-CoV infection..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2005-02-28 2005 |
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| Erschienen: |
2005-02-28 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2005 |
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| Enthalten in: |
Lin chuang fei ke za zhi - (2005), 1 vom: 28. Feb., Seite 5 Original Letters: Enthalten in 临床肺科杂志 (DE-600)2990313-0 (DE-600)2990313-0 安徽省合肥市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Recent progress in the management of SARS in China |
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| Beteiligte Personen: |
钟南山 [VerfasserIn] |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Themen: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ180161792 |
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| 520 | |a There were three events of SARS in the mainland of China from November 2002 to May 2004.Although a SARS pandemic broke out during the first event,it was circumvented during the latter two,due to establishment of strict policies and control measures.A study of molecular evolution of SARS-CoV during SARS-pandemic in the mainland showed that deletion of nucleotides in orf8 was closely associated with the infectivity and toxicity of SARS-CoV.Generally speaking,SARS-CoV was transmitted via droplets over a short distance.Under certain circumstance,as in the Amoy Garden,virus can spread via air-borne transmission.Some wildlife from Felidae Carnivora(flesh-eating animal of the cat family),like civet cats,were suspected as important reservoir in SARS-CoV transmission to human beings (Guan Y et al:Science 2003).By entering exotic food markets,these suspects have become the topmost link by far recognized in SARS transmission route as dangerous sources undermining the preventing of SARS.Early in the year of 2004,the Guangdong local government and Department of Public Health tokk strong actions regarding strict control of the wildlife market and `four earliness' to stop transmission from human to human.This control strategy seems to have effectively prevented the second SARS event from evolving into an outbreak.Studies have shown evidences of sub-clinical patients of SARS.Antigen detection targeting at N-protein of SARS-CoV has also shown benefit in confirming diagnosis within 7 days after onset.From a controlled study in Guangzhou,administreation of corticosteroids was associated with reduced mortality and shorter hospital stay in SARS patients with acute lung injury of ARDS.Clinical trials using inactivated whole SARS-CoV vaccine is currently in process.Results will be available at the beginning of next year.Researches on genotherapy using small interfering RNA(SiRNA) have also been initiated for the prevention and treatment of SARS-CoV infection. | ||
| 610 | 2 | 4 | |a 广州市呼吸病研究所 |
| 610 | 2 | 4 | |a 中国工程院院士 |
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