地塞米松防治豚鼠钩端螺旋体病肺弥漫性出血机理的实验研究 : = Experimental Study of the Effect of Dexamethasone on Pulmonary Diffuse Hemorrhage and Energy Metabolism of Mitochondria in the Liver of Guinea Pig Infected with Leptospirosis
This experiment was designed to study the curative effect of dexamethasone on leptospirosis with pulmonary diffuse hemorrhage(PDH) in guinea pig model.The guinea pigs were randomly divided into four groups:the infected group,all animals developed PDH( n =10);the infected plus treated group( n =10);the treated control group( n =10);and the normal control group( n =10).The gross and microscopic observations in lung, liver and kidney were made. Also, ultrastructural changes of mitochondria in liver were examined,and the lactic acid level and mitochondrial ATPase activity in liver were determined.The results showed that there was significant difference in mortality,in gross and microscopic changes in lung,liver and kidney,and in the changes of mitochondrial ultrastructures,ATPase activity and lactic acid level in liver between the infected group and the infected plus treated group( P <0.01).These findings suggest that the pharmacologic dose of dexamethasone injected intravenously in the early stage of PDH may have some beneficial effect on the emergency treatment of leptospirosis with PDH. The mechanism appears to be related to its effect on the inhibition of glycolysis and increasing oxidative phosphorylation in mitochondria..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
1999-12-30 1999 |
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| Erschienen: |
1999-12-30 |
| Enthalten in: |
Zur Gesamtaufnahme - year:1999 |
|---|---|
| Enthalten in: |
Si chuan da xue xue bao. Yi xue ban - (1999), 4 vom: 30. Dez., Seite 72-75 Original Letters: Enthalten in 四川大学学报. 医学版 (DE-600)2991254-4 (DE-600)2991254-4 四川省成都市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Experimental Study of the Effect of Dexamethasone on Pulmonary Diffuse Hemorrhage and Energy Metabolism of Mitochondria in the Liver of Guinea Pig Infected with Leptospirosis |
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| Beteiligte Personen: |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Themen: |
医药卫生科技 |
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| Umfang: |
4 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ026400790 |
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| 245 | 1 | 0 | |a 地塞米松防治豚鼠钩端螺旋体病肺弥漫性出血机理的实验研究 |b = Experimental Study of the Effect of Dexamethasone on Pulmonary Diffuse Hemorrhage and Energy Metabolism of Mitochondria in the Liver of Guinea Pig Infected with Leptospirosis |
| 246 | 3 | 1 | |a Experimental Study of the Effect of Dexamethasone on Pulmonary Diffuse Hemorrhage and Energy Metabolism of Mitochondria in the Liver of Guinea Pig Infected with Leptospirosis |
| 264 | 1 | |c 1999-12-30 | |
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| 520 | |a This experiment was designed to study the curative effect of dexamethasone on leptospirosis with pulmonary diffuse hemorrhage(PDH) in guinea pig model.The guinea pigs were randomly divided into four groups:the infected group,all animals developed PDH( n =10);the infected plus treated group( n =10);the treated control group( n =10);and the normal control group( n =10).The gross and microscopic observations in lung, liver and kidney were made. Also, ultrastructural changes of mitochondria in liver were examined,and the lactic acid level and mitochondrial ATPase activity in liver were determined.The results showed that there was significant difference in mortality,in gross and microscopic changes in lung,liver and kidney,and in the changes of mitochondrial ultrastructures,ATPase activity and lactic acid level in liver between the infected group and the infected plus treated group( P <0.01).These findings suggest that the pharmacologic dose of dexamethasone injected intravenously in the early stage of PDH may have some beneficial effect on the emergency treatment of leptospirosis with PDH. The mechanism appears to be related to its effect on the inhibition of glycolysis and increasing oxidative phosphorylation in mitochondria. | ||
| 610 | 2 | 4 | |a 华西医科大学校医院 |
| 610 | 2 | 4 | |a 成都 |
| 650 | 4 | |a 医药卫生科技 | |
| 650 | 4 | |a Medicine & Public Health | |
| 650 | 4 | |a 药理学 | |
| 650 | 4 | |a 地塞米松 | |
| 650 | 4 | |a 豚鼠 | |
| 650 | 4 | |a 肺弥漫性出血 | |
| 650 | 4 | |a 钩端螺旋体病 | |
| 650 | 4 | |a 线粒体 | |
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