SARS肺纤维化发病机制的比较医学研究 : = Comparative Study on Pathogenesis of SARS Pulmonary Fibrosis
Objective To explore the possibility of applying SARS-CoV infected animal model to clarify the pathogenesis of pulmonary fibrosis(PF) in SARS.Methods We compared the difference and similarity of SARS features and pathogenesis between SARS patients and SARS animal model emphasized on PF.Results Beginning from alveolitis,PF in different diseases has similar pathological changes in a progressive and reparative process.About 7-8% of SARS convalescent patients showed apparent PF,which affected their life quality and increased medical treatment costs.PF in SARS patients appears in the early stage and develops very fast.These patients died within a few days with severe pathological changes in many organs,especially in the lungs.SARS-CoV infected animal model had been established,which showed similar clinical,serological and pathological changes to those in SARS patients.In these animals,PF is also apparent with increased amount of fibroblasts and collagen.Conclusions SARS-CoV infected animal models are useful in studies on pathogenesis of pulmonary fibrosis in SARS patients..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2005-12-30 2005 |
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| Erschienen: |
2005-12-30 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2005 |
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| Enthalten in: |
Zhong guo bi jiao yi xue za zhi - (2005), 6 vom: 30. Dez., Seite 15-18 Original Letters: Enthalten in 中国比较医学杂志 (DE-600)2994198-2 (DE-600)2994198-2 北京市 |
| Reihe: |
China Academic Journals (CAJ), A, 理工A(数学物理力学天地生) = Mathematics/ Physics/ Mechanics/ Astronomy China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Comparative Study on Pathogenesis of SARS Pulmonary Fibrosis |
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| Beteiligte Personen: |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Themen: |
严重急性呼吸综合征 |
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| Umfang: |
4 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ02142957X |
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| 245 | 1 | 0 | |a SARS肺纤维化发病机制的比较医学研究 |b = Comparative Study on Pathogenesis of SARS Pulmonary Fibrosis |
| 246 | 3 | 1 | |a Comparative Study on Pathogenesis of SARS Pulmonary Fibrosis |
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| 520 | |a Objective To explore the possibility of applying SARS-CoV infected animal model to clarify the pathogenesis of pulmonary fibrosis(PF) in SARS.Methods We compared the difference and similarity of SARS features and pathogenesis between SARS patients and SARS animal model emphasized on PF.Results Beginning from alveolitis,PF in different diseases has similar pathological changes in a progressive and reparative process.About 7-8% of SARS convalescent patients showed apparent PF,which affected their life quality and increased medical treatment costs.PF in SARS patients appears in the early stage and develops very fast.These patients died within a few days with severe pathological changes in many organs,especially in the lungs.SARS-CoV infected animal model had been established,which showed similar clinical,serological and pathological changes to those in SARS patients.In these animals,PF is also apparent with increased amount of fibroblasts and collagen.Conclusions SARS-CoV infected animal models are useful in studies on pathogenesis of pulmonary fibrosis in SARS patients. | ||
| 610 | 2 | 4 | |a 中国医学科学院中国协和医科大学实验动物研究所 |
| 610 | 2 | 4 | |a 北京 |
| 650 | 4 | |a 理工A(数学物理力学天地生) | |
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