|
|
|
|
LEADER |
01000cam a22002652 4500 |
001 |
835788296 |
003 |
DE-627 |
005 |
20220808193523.0 |
007 |
cr uuu---uuuuu |
008 |
150929s2015 sz |||||o 00| ||eng c |
020 |
|
|
|a 9783319087177
|9 978-3-319-08717-7
|
035 |
|
|
|a (DE-627)835788296
|
035 |
|
|
|a (DE-576)9835788294
|
035 |
|
|
|a (DE-599)GBV835788296
|
035 |
|
|
|a (EBC)EBC3568369
|
035 |
|
|
|a (EBR)ebr11090580
|
035 |
|
|
|a (RPAM)MIL822284
|
035 |
|
|
|a (EBL)EBL3568369
|
035 |
|
|
|a (EBP)034068538
|
040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
041 |
|
|
|a eng
|
044 |
|
|
|c XA-CH
|
050 |
|
0 |
|a QP551
|
082 |
0 |
|
|a 572
|2 23
|
082 |
0 |
|
|a 616.3995
|
245 |
1 |
0 |
|a ADAMTS13
|b biology and disease
|c George M. Rodgers, editor
|
264 |
|
1 |
|a Cham
|b Springer
|c 2015
|
300 |
|
|
|a Online-Ressource
|
336 |
|
|
|a Text
|b txt
|2 rdacontent
|
337 |
|
|
|a Computermedien
|b c
|2 rdamedia
|
338 |
|
|
|a Online-Ressource
|b cr
|2 rdacarrier
|
500 |
|
|
|a Includes bibliographical references and index
|
505 |
8 |
0 |
|a Preface; Contents; Contributors; Chapter 1: History of Thrombotic Thrombocytopenic Purpura and the von Willebrand Factor-Cleaving Protease, ADAMTS13; 1.1 Thrombotic Thrombocytopenic Purpura: The Initial Case Report, the Name of the Disease, and the Diagnostic Pentad of Clinical and Laboratory Findings; 1.2 A Congenital Form of Microangiopathic Hemolysis and Thrombocytopenia; 1.3 Pathophysiological Hypotheses, Discovery of von Willebrand Factor (VWF)-Cleaving Protease, and Its Deficiency in TTP; 1.4 Therapeutic Efforts in TTP; 1.5 Differential Diagnosis of TTP, HUS, and Other TMAs
|
505 |
8 |
0 |
|a 1.6 ConclusionsReferences; Chapter 2: Overview of the ADAMTS Superfamily; 2.1 What Are ADAMTS Proteases, and How Are They Related to Other Metalloproteases?; 2.2 Biosynthesis, Posttranslational Modification, and Regulation of ADAMTS Activity; 2.3 Biological and Disease Pathways Involving ADAMTS Proteases; 2.4 Summary and Conclusions; References; Chapter 3: ADAMTS13: Structure and Function; 3.1 Introduction; 3.2 ADAMTS13 Domain Organization; 3.3 ADAMTS13 Domain Function; 3.3.1 Prodomain; 3.3.2 Metalloprotease Domain; 3.3.3 Disintegrin-Like Domain; 3.3.4 Cysteine-Rich Domain
|
505 |
8 |
0 |
|a 3.3.5 Spacer Domain3.3.6 Thrombospondin Type 1 Repeats; 3.3.7 CUB Domains; 3.4 Regulation of ADAMTS13 Activity; 3.4.1 Natural Inhibitors; 3.4.2 Divalent Metal Ions; 3.4.3 Shear Stress; 3.4.4 Coagulation Factor VIII; 3.4.5 Platelets and Their Surface Receptors; 3.5 Anti-ADAMTS13 Autoantibody; 3.6 Reengineering ADAMTS13 for Therapy; 3.7 Beyond TTP; References; Chapter 4: ADAMTS13 and Angiogenesis; 4.1 Introduction; 4.2 Endothelial Cell Secretion of ADAMTS13; 4.3 ADAMTS13 and Normal Angiogenesis In Vitro
|
505 |
8 |
0 |
|a 4.4 ADAMTS13 Promotes Blood Vessel Migration/Formation in the Chicken Chorioallantoic Membrane Model4.5 Antiangiogenic Roles of ADAMTS13; 4.6 Studies of Domain-Function Relationships; 4.7 Expression of ADAMTS13 in Brain-Tumor Cells: Implications for Tumor Angiogenesis; References; Chapter 5: Hereditary Deficiency of ADAMTS13 Activity: Upshaw-Schulman Syndrome; 5.1 Introduction; 5.2 Historical Background; 5.3 Diagnostic Criteria for USS; 5.4 Mechanism of TTP Episodes in USS; 5.5 USS Registry in Japan; 5.6 Genotype-Phenotype Relationship; 5.7 Pregnancy; 5.8 Renal Involvement
|
505 |
8 |
0 |
|a 5.9 Treatment of USS5.10 Conclusion; References; Chapter 6: Acquired Thrombotic Thrombocytopenic Purpura; 6.1 From a Syndrome to a Disease; 6.1.1 A Mechanistic Definition of TTP; 6.1.2 The Basis for the Mechanistic Definition of TTP; 6.1.2.1 Is There TTP Without ADAMTS13 Deficiency?; 6.1.2.2 Does TTP Require a Second Hit in Addition to ADAMTS13 Deficiency?; 6.2 From ADAMTS13 Deficiency to Thrombosis; 6.2.1 Pathology; 6.2.1.1 TTP Does Not Cause TMA; 6.2.1.2 Thrombosis in Large Arteries; 6.2.2 Shear Stress and Platelet Thrombosis in TTP
|
505 |
8 |
0 |
|a 6.2.2.1 The Hemostatic Activity of VWF Is Linked to Its Responsiveness to Shear Stress
|
520 |
|
|
|a This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility. ℗ℓ Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases
|
533 |
|
|
|a Online-Ausg.
|
650 |
|
0 |
|a Proteolytic enzymes
|
650 |
|
0 |
|a Cytology
|
650 |
|
0 |
|a Proteomics
|
650 |
|
0 |
|a Thrombotic thrombocytopenic purpura
|
650 |
|
0 |
|a Biochemistry
|
650 |
|
4 |
|a Cytology
|
650 |
|
4 |
|a Electronic books
|
700 |
1 |
|
|a Rodgers, George M.
|e editor
|4 edt
|
776 |
1 |
|
|z 3319087177
|
776 |
1 |
|
|z 9783319087160
|
776 |
1 |
|
|z 9783319087177
|
776 |
0 |
8 |
|i Print version
|a ADAMTS13 : Biology and Disease
|
856 |
4 |
0 |
|u http://gbv.eblib.com/patron/FullRecord.aspx?p=3568369
|x Verlag
|3 Volltext
|
856 |
4 |
0 |
|u https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=3568369
|m X:EBC
|x Aggregator
|z lizenzpflichtig
|3 Volltext
|
912 |
|
|
|a ZDB-30-PQE
|
912 |
|
|
|a GBV_ILN_206
|
912 |
|
|
|a ISIL_DE-Brg3
|
912 |
|
|
|a SYSFLAG_1
|
912 |
|
|
|a GBV_KXP
|
912 |
|
|
|a GBV_ILN_2021
|
912 |
|
|
|a ISIL_DE-289
|
951 |
|
|
|a BO
|
953 |
|
|
|2 045F
|a 572
|
953 |
|
|
|2 045F
|a 616.3995
|
980 |
|
|
|2 206
|1 01
|x 3350
|b 1708105905
|c 00
|f --%%--
|d Online-Ressource
|e g
|j --%%--
|h OLR-EBL
|k If you are a ThHF affiliate and the E-Book is not fully accessible, please send us a purchase or short time loan request. All others: Inter-library loans and guest access on campus premises is not possible.
|y zh
|z 18-08-17
|
980 |
|
|
|2 2021
|1 01
|x DE-289
|b 3845576537
|c 00
|f --%%--
|d --%%--
|e --%%--
|j n
|y l01
|z 30-01-21
|
981 |
|
|
|2 206
|1 01
|x 3350
|y Full Text only for ThHF affiliates
|r https://thh-friedensau.idm.oclc.org/login?url=http://ebookcentral.proquest.com/lib/thhfriedensau/detail.action?docID=3568369
|
981 |
|
|
|2 2021
|1 01
|x DE-289
|r https://ebookcentral.proquest.com/lib/kiz-uniulm/detail.action?docID=3568369
|
995 |
|
|
|2 206
|1 01
|x 3350
|a OLR-EBL
|