Renin angiotensin system and the heart / edited by Walmor C. De Mello
Recent studies have shown that the heart possesses an intrinsic renin angiotensin system that is controlled by tissue-specific parameters that are activated by biomechanical stress. This book reviews the latest information on the way in which both the plasma and cardiac renin angiotensin systems affect heart function. It covers the cell and molecular biology of these systems, with contributions on renin synthesis, uptake and the intracellular signalling pathways. Particular insight comes from transgenic mouse models in which either mouse or human genes for various components of the renin angio.
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
c2004 |
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| Erschienen: |
Hoboken, NJ: John Wiley & Sons ; c2004 |
| Reproduktion: |
Online-Ausg. ; Palo Alto, Calif ; ebrary ; 2009 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
DeMello, Walmor Carlos [Sonstige Person] |
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| Links: |
Volltext |
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| ISBN: |
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| Nlm: |
WG 106 |
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| Themen: |
Heart |
| RVK: |
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| Anmerkungen: |
Includes bibliographical references and index |
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| Umfang: |
Online-Ressource (xii, 244 p) ; IllustratorIn ; 25 cm |
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| doi: |
10.1002/0470032103 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
686431073 |
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| 245 | 1 | 0 | |a Renin angiotensin system and the heart |c edited by Walmor C. De Mello |
| 264 | 1 | |a Hoboken, NJ |b John Wiley & Sons |c c2004 | |
| 300 | |a Online-Ressource (xii, 244 p) |b ill |c 25 cm | ||
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Includes bibliographical references and index | ||
| 505 | 8 | 0 | |a Renin Angiotensin System and the Heart; Contents; Preface; List of Contributors; 1 Intracellular Signaling and the Cardiac Renin Angiotensin System; Introduction; Regulation of cardiac remodeling by Ang II; AT(1)-mediated intracellular signaling; Paracrine/autocrine actions of Ang II; Intracrine actions of Ang II; Summary; References; 2 Cardiac Physiology and the Renin Angiotensin System: Lessons from Transgenic Animal Models; Introduction; An overview of transgenesis; Transgenic evidence of a cardiac-based RAS; Transgenic evidence of cardiac renin uptake; Prorenin activity |
| 505 | 8 | 0 | |a Role of the RAS in cardiac hypertrophy and fibrosisConclusions and questions; References; 3 Prorenin Uptake in the Heart; Introduction; How does the heart sequester circulating (pro)renin?; (Pro)renin receptors; Mannose 6-phosphate/insulin-like growth factor II receptors; M6P/IGFII receptor-mediated (pro)renin binding and prorenin activation; Does prorenin mediate direct (Ang II-independent) effects?; Intracellular versus extracellular angiotensin generation; Perspective; References; 4 Role of Local Renin Angiotensin Systems in Cardiac Damage; Introduction; AT(1) and cardiac hypertrophy |
| 505 | 8 | 0 | |a AT(1) and cardiac fibrosisAT(2) in cardiac hypertrophy and fibrosis; Conclusion; References; 5 Cardiac Renin: De Novo Synthesis and Uptake; Introduction; Presence of renin in the heart; Uptake of renin into the heart; Cardiac expression of renin; Discovery of a second transcript of the rat renin gene; Differential expression of preprorenin and exon 1A renin transcripts; Possible functions of exon 1A renin; Significance of renin uptake and expression: concluding remarks; References; 6 The Cardiac Renin Receptors; Introducion; The renin-binding proteins; The renin receptor; Conclusion |
| 505 | 8 | 0 | |a References7 Angiotensin II AT(2) Receptors and Cardiac Function; Possible roles of AT(2) receptor stimulation associated with selective AT(1) receptor blockade; Expression of AT(2) receptor in cardiac tissue; Role of AT(2) receptor in cardiac structure and function; References; 8 The Heart: A Target for the Renin Angiotensin System. Evidence of an Intracrine System; Introduction; RAS and intercellular signaling; Ang II, cell coupling and growth; an important relationship?; Evidence for an intracellular RAS; On the possible role of endogenous Ang II on heart cell communication |
| 505 | 8 | 0 | |a Aldosterone modulates the effect of Ang IIEffect of intracellular and extracellular Ang II on the inward calcium current; Acknowledgments; References; 9 ACE2: Its Role in the Counter-regulatory Response to Heart Failure; Introduction; A paradigm of human heart failure: secondary activation of neurohormonal systems and a counterbalancing response; Angiotensin metabolites; Overview of peptidases; Carboxypeptidases; ACE2, a novel homolog of ACE, functions as a carboxypeptidase and angiotensinase; ACE2-mediated hydrolysis of biological peptides; Genetics and cross-species homology |
| 505 | 8 | 0 | |a The ACE2 knockout mouse |
| 520 | |a Recent studies have shown that the heart possesses an intrinsic renin angiotensin system that is controlled by tissue-specific parameters that are activated by biomechanical stress. This book reviews the latest information on the way in which both the plasma and cardiac renin angiotensin systems affect heart function. It covers the cell and molecular biology of these systems, with contributions on renin synthesis, uptake and the intracellular signalling pathways. Particular insight comes from transgenic mouse models in which either mouse or human genes for various components of the renin angio | ||
| 530 | |a Electronic reproduction; Available via World Wide Web | ||
| 533 | |a Online-Ausg. |b Palo Alto, Calif |c ebrary |d 2009 |n Electronic reproduction; Available via World Wide Web |7 |2009|||||||||| | ||
| 650 | 0 | |a Heart |x Physiology | |
| 650 | 0 | |a Heart |x Pathophysiology | |
| 650 | 0 | |a Renin-angiotensin system | |
| 650 | 2 | |a Heart Diseases |x physiopathology | |
| 650 | 2 | |a Renin-Angiotensin System |x physiology | |
| 650 | 2 | |a Heart |x drug effects | |
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