Characterization Of Pirfenidone Effects In Human Cardiac Fibroblasts / vorgelegt von Friederike Meyer
Background Cardiac fibrosis is a major problem in heart diseases, but it is still lacking an effective therapy. The drug pirfenidone has shown several anti-fibrotic effects in animal models of heart diseases and is already approved for the treatment of idiopathic pulmonary fibrosis. This led to the hypothesis that pirfenidone could have beneficial effects as an anti-fibrotic treatment of the human diseased heart; however, data on its effect in human cardiac fibroblasts are still missing. Methods General effects were studied in 2D cultures of human cardiac fibroblasts (hCF). Cells were treat....
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
Göttingen: 2024 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Meyer, Friederike [VerfasserIn] |
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| Hochschulschrift: |
| Links: |
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| Themen: |
Cardiac fibroblasts |
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| Umfang: |
1 Online-Ressource ; Illustrationen, Diagramme |
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| Weitere IDs: |
urn:nbn:de:gbv:7-ediss-15202-4 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
1885424264 |
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| 520 | |a Background Cardiac fibrosis is a major problem in heart diseases, but it is still lacking an effective therapy. The drug pirfenidone has shown several anti-fibrotic effects in animal models of heart diseases and is already approved for the treatment of idiopathic pulmonary fibrosis. This led to the hypothesis that pirfenidone could have beneficial effects as an anti-fibrotic treatment of the human diseased heart; however, data on its effect in human cardiac fibroblasts are still missing. Methods General effects were studied in 2D cultures of human cardiac fibroblasts (hCF). Cells were treat... | ||
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