Impact of cellular morphology and three-tiered nuclear grade on progression of conventional renal cell carcinoma / Lilla Domonkos, Maria Yusenko, Gyula Kovacs, Lehel Peterfi
Aims and methods The aims of this study were to evaluate the prognostic impact of cytomorphology and three-tiered grading on tumour-free survival of patients with conventional renal cell carcinoma (cRCC). Formalin-fixed, paraffin-embedded samples from 710 patients were assessed and the results were evaluated according to the clinical data. - Results Kaplan-Meier regression model showed that 90.9% of patients with clear cell, and 50.9% with pure eosinophilic cRCC were free of metastasis during follow-up. The three-triered grading showed a good correlation with progression as 95.2% of patients with of G1 tumours, 66.1% with G2 tumours and only 25.3% with G3 tumours were tumour free (p<0.001). The grading was correlated with cytomorphology and coagulation necrosis. In multivariate analysis, tumour grade and stage were independent prognostic markers (p<0.001). - Conclusions The three-tiered grading predicts the progression of cRCC irrespectively of cytomorphology. However, the cytomorphology and necrosis show a good correlation with three-tiered grading in estimate disease progression..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
March 20, 2024 2024 |
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| Erschienen: |
March 20, 2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:77 |
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| Enthalten in: |
Journal of clinical pathology - 77(2024), 4 vom: März, Seite 246-250 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Domonkos, Lilla [VerfasserIn] |
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| Links: |
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| Themen: |
Histology |
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| Anmerkungen: |
Zuerst veröffentlicht: 19. Dezember 2023 Gesehen am 22.03.2024 |
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| Umfang: |
Illustrationen 5 |
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| doi: |
10.1136/jcp-2023-209094 |
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| funding: |
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| 245 | 1 | 0 | |a Impact of cellular morphology and three-tiered nuclear grade on progression of conventional renal cell carcinoma |c Lilla Domonkos, Maria Yusenko, Gyula Kovacs, Lehel Peterfi |
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| 520 | |a Aims and methods The aims of this study were to evaluate the prognostic impact of cytomorphology and three-tiered grading on tumour-free survival of patients with conventional renal cell carcinoma (cRCC). Formalin-fixed, paraffin-embedded samples from 710 patients were assessed and the results were evaluated according to the clinical data. - Results Kaplan-Meier regression model showed that 90.9% of patients with clear cell, and 50.9% with pure eosinophilic cRCC were free of metastasis during follow-up. The three-triered grading showed a good correlation with progression as 95.2% of patients with of G1 tumours, 66.1% with G2 tumours and only 25.3% with G3 tumours were tumour free (p<0.001). The grading was correlated with cytomorphology and coagulation necrosis. In multivariate analysis, tumour grade and stage were independent prognostic markers (p<0.001). - Conclusions The three-tiered grading predicts the progression of cRCC irrespectively of cytomorphology. However, the cytomorphology and necrosis show a good correlation with three-tiered grading in estimate disease progression. | ||
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