Characterization of the molecular interaction between α-synuclein and prion protein / vorgelegt von Renato Garcia Domingues
The interaction between α-synuclein (aSyn) and prion protein (PrP) has been implicated in the pathogenesis of synucleinopathies. However, the nature of this interaction remains poorly understood. Here, we employed a combination of biophysical and cellular assays to characterize the interaction between aSyn and PrP. Our results demonstrate that the C-terminal region of aSyn interacts with PrP in an orientation-specific manner through electrostatic interactions, and suggest that tryptophan residues on PrP may also bind to the tyrosine residues of aSyn through aromatic interactions. We further....
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
Göttingen: 2024 |
| Sprache: |
Portugiesisch |
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| Beteiligte Personen: |
Garcia Domingues, Renato [VerfasserIn] |
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| Hochschulschrift: |
| Links: |
Volltext [kostenfrei] |
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| Themen: |
Aggregation |
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| Umfang: |
1 Online-Ressource ; Illustrationen, Diagramme |
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| Weitere IDs: |
urn:nbn:de:gbv:7-ediss-15177-5 |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Characterization of the molecular interaction between α-synuclein and prion protein |c vorgelegt von Renato Garcia Domingues |
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| 520 | |a The interaction between α-synuclein (aSyn) and prion protein (PrP) has been implicated in the pathogenesis of synucleinopathies. However, the nature of this interaction remains poorly understood. Here, we employed a combination of biophysical and cellular assays to characterize the interaction between aSyn and PrP. Our results demonstrate that the C-terminal region of aSyn interacts with PrP in an orientation-specific manner through electrostatic interactions, and suggest that tryptophan residues on PrP may also bind to the tyrosine residues of aSyn through aromatic interactions. We further... | ||
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