Toward photodynamic cancer chemotherapy with C60-Doxorubicin nanocomplexes / Anna Grebinyk, Svitlana Prylutska, Sergii Grebinyk, Yuriy Prylutskyy, Uwe Ritter, Olga Matyshevska, Thomas Dandekar, Marcus Frohme
Recent progress in nanotechnology has attracted interest to a biomedical application of the carbon nanoparticle C60 fullerene (C60) due to its unique structure and versatile biological activity. The dual functionality of C60 as a photosensitizer and a drug nanocarrier sets an opportunity to improve the efficiency of chemotherapeutic drugs for cancer cells. Pristine C60 demonstrates time-dependent accumulation with predominant mitochondrial localization in cancer cells. Nanomolar amounts of C60-drug nanocomplexes in 1:1 and 2:1 molar ratios improve the efficiency of cell treatment, complementing it with photodynamic approach. The cooperative enhancement interactions between mechanisms of chemo- and photodynamic therapies contribute to the obtained synergistic effect (namely “1+1>2”). A strong synergy of treatments arising from the combination of C60-mediated drug delivery and C60 photoexcitation indicates that a combination of chemo- and photodynamic treatments with C60-drug nanoformulations could provide a promising synergetic approach for cancer treatment..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Nanomaterials for photodynamics therapy - (2023), Seite 489-522 |
| Sprache: |
Englisch |
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| Weiterer Titel: |
C 60-Doxorubicin |
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| Beteiligte Personen: |
Grebinyk, Anna, 19XX- [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| doi: |
10.1016/B978-0-323-85595-2.00005-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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