Investigating the Ultrastructural Consequences of Aging on Murine Inner Hair Cell Ribbon Synapses / vorgelegt von Loujin Slitin

The ribbon synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are first synapses of the auditory pathway. They mediate the harmonized and tireless neurotransmission needed for continuous sound encoding. Additionally, these synapses display an unconventional molecular architecture well-suited to sustain high rates and exceptional temporal precision in signal transduction. Synaptic vesicles (SVs) at the ribbon synapse are organized, according to their location, in morphologically distinct pools; the ribbon-associated (RA) and the membrane-proximal (MP) pool. Proteinac....

Medienart:

E-Book

Erscheinungsjahr:

2024

Erschienen:

Göttingen: 2024

Sprache:

Englisch

Beteiligte Personen:

Slitin, Loujin [VerfasserIn]
Wichmann, Carolin [Akademische/r BetreuerIn]
Outeiro, Tiago [Akademische/r BetreuerIn]
Möbius, Wiebke [Akademische/r BetreuerIn]

Hochschulschrift:

Dissertation, Georg-August-Universität Göttingen, 2023

Links:

Volltext [kostenfrei]
Volltext [kostenfrei]

Themen:

Aging
Electron tomography
FIB-SEM
High pressure freezing
Hochschulschrift
Otoferlin
RIBEYE
Ribbon synapses

Umfang:

1 Online-Ressource ; Illustrationen, Diagramme

Weitere IDs:

urn:nbn:de:gbv:7-ediss-15158-0

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

1882561295