Mechanisms underlying age-related decline in mammalian female fertility / vorgelegt von Ninadini Sharma
Reproductive longevity is crucial for fertility and impacts healthy ageing. Unlike in men, fertility in women starts to decline several decades before other signs of ageing set in. Female fertility is restricted by a limited supply of oocytes established at birth. Loss of oocyte quantity and quality occurs progressively from birth and is accelerated as women approach their mid-30s. The DNA damage response is one of the primary pathways believed to drive oocyte loss. Elevated levels of DNA double-strand breaks (DSBs) can trigger oocyte death, and thus contribute to the loss of female fertili....
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
Göttingen: 2024 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sharma, Ninadini [VerfasserIn] |
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| Hochschulschrift: |
| Links: |
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| Themen: |
Aging |
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| Umfang: |
1 Online-Ressource ; Illustrationen, Diagramme |
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| Weitere IDs: |
urn:nbn:de:gbv:7-ediss-15154-7 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a Reproductive longevity is crucial for fertility and impacts healthy ageing. Unlike in men, fertility in women starts to decline several decades before other signs of ageing set in. Female fertility is restricted by a limited supply of oocytes established at birth. Loss of oocyte quantity and quality occurs progressively from birth and is accelerated as women approach their mid-30s. The DNA damage response is one of the primary pathways believed to drive oocyte loss. Elevated levels of DNA double-strand breaks (DSBs) can trigger oocyte death, and thus contribute to the loss of female fertili... | ||
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