Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen / Maximilian Schmutz, Manuela Zucknick, Richard F. Schlenk, Daniel Mertens, Axel Benner, Dieter Weichenhan, Oliver Mücke, Konstanze Döhner, Christoph Plass, Lars Bullinger and Rainer Claus
Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from treatment with hypomethylating agents (HMAs), but no predictive biomarkers for therapy response exist. Here, we investigated whether unbiased genome-wide assessment of pre-treatment DNA-methylation profiles in AML bone marrow blasts can help to identify patients who will achieve a remission after an azacytidine-containing induction regimen..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
26 October 2023 2023 |
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| Erschienen: |
26 October 2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Clinical epigenetics - 15(2023), Artikel-ID 171, Seite 1-16 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Schmutz, Maximilian [VerfasserIn] |
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| Links: |
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| Themen: |
AML |
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| Anmerkungen: |
Gesehen am 05.03.2024 |
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| Umfang: |
16 |
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| doi: |
10.1186/s13148-023-01580-z |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from treatment with hypomethylating agents (HMAs), but no predictive biomarkers for therapy response exist. Here, we investigated whether unbiased genome-wide assessment of pre-treatment DNA-methylation profiles in AML bone marrow blasts can help to identify patients who will achieve a remission after an azacytidine-containing induction regimen. | ||
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