Prolonged thrombocytopenia and severe transfusion reaction after ABO-incompatible allogeneic hematopoietic stem cell transplantation in a patient with chronic myelomonocytic leukemia / Lina S. Silva-Bermudez, Daniela Heidenreich, Stefan A. Klein, Patrick Wuchter, Harald Klüter, Sabine Kayser
Introduction: Major ABO-incompatible allogeneic hematopoietic stem cell transplantation (allo-HCT) is a common practice and represents a challenging transfusion scenario. Prolonged thrombocytopenia with increased platelet transfusion needs is one of its reported adverse effects, and this has been linked to the persistence of recipient anti-donor isoagglutinins. Case Presentation: A 55-year-old male patient, O Rh(D)-positive, with chronic myelomonocytic leukemia underwent major incompatible allo-HCT from a A Rh(D)-negative donor. He presented with prolonged thrombocytopenia and multiple transfusion reactions after A Rh(D)-negative platelet transfusions. Considering the outcomes of numerous examinations, we tested the anti-A1 titers, finding a significant persistence of anti-donor isoagglutinins. We limited platelet transfusions to blood group O Rh(D)-negative donors, which significantly decreased the requirement for platelet transfusions. In addition, the transfusion reactions ceased. Conclusion: In case of transfusion reactions against platelet products in major ABO-incompatible allo-HCT patients, isoagglutinin monitoring should be considered and a change in the platelet transfusion protocol may be beneficial in patients presenting high isotiters against recipient’s blood type..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
January 09 2024 2024 |
|---|---|
| Erschienen: |
January 09 2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
Transfusion medicine and hemotherapy - (2024) online ahead of print |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Silva Bermudez, Lina Susana [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Anmerkungen: |
Gesehen am 22.02.2024 |
|---|
| Umfang: |
Illustrationen 4 |
|---|
| doi: |
10.1159/000534272 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
1881441563 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | 1881441563 | ||
| 003 | DE-627 | ||
| 005 | 20240307020035.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240222s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1159/000534272 |2 doi | |
| 035 | |a (DE-627)1881441563 | ||
| 035 | |a (DE-599)KXP1881441563 | ||
| 035 | |a (OCoLC)1425199920 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 100 | 1 | |a Silva Bermudez, Lina Susana |e verfasserin |0 (DE-588)1252924410 |0 (DE-627)1794802517 |4 aut | |
| 245 | 1 | 0 | |a Prolonged thrombocytopenia and severe transfusion reaction after ABO-incompatible allogeneic hematopoietic stem cell transplantation in a patient with chronic myelomonocytic leukemia |c Lina S. Silva-Bermudez, Daniela Heidenreich, Stefan A. Klein, Patrick Wuchter, Harald Klüter, Sabine Kayser |
| 264 | 1 | |c January 09 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.02.2024 | ||
| 520 | |a Introduction: Major ABO-incompatible allogeneic hematopoietic stem cell transplantation (allo-HCT) is a common practice and represents a challenging transfusion scenario. Prolonged thrombocytopenia with increased platelet transfusion needs is one of its reported adverse effects, and this has been linked to the persistence of recipient anti-donor isoagglutinins. Case Presentation: A 55-year-old male patient, O Rh(D)-positive, with chronic myelomonocytic leukemia underwent major incompatible allo-HCT from a A Rh(D)-negative donor. He presented with prolonged thrombocytopenia and multiple transfusion reactions after A Rh(D)-negative platelet transfusions. Considering the outcomes of numerous examinations, we tested the anti-A1 titers, finding a significant persistence of anti-donor isoagglutinins. We limited platelet transfusions to blood group O Rh(D)-negative donors, which significantly decreased the requirement for platelet transfusions. In addition, the transfusion reactions ceased. Conclusion: In case of transfusion reactions against platelet products in major ABO-incompatible allo-HCT patients, isoagglutinin monitoring should be considered and a change in the platelet transfusion protocol may be beneficial in patients presenting high isotiters against recipient’s blood type. | ||
| 700 | 1 | |a Heidenreich, Daniela |d 1976- |e verfasserin |0 (DE-588)124462073 |0 (DE-627)36336479X |0 (DE-576)294183248 |4 aut | |
| 700 | 1 | |a Klein, Stefan |e verfasserin |0 (DE-588)1042491836 |0 (DE-627)769066372 |0 (DE-576)393988791 |4 aut | |
| 700 | 1 | |a Wuchter, Patrick |d 1975- |e verfasserin |0 (DE-588)123450284 |0 (DE-627)082563624 |0 (DE-576)184642574 |4 aut | |
| 700 | 1 | |a Klüter, Harald |e verfasserin |0 (DE-588)1026722470 |0 (DE-627)727105132 |0 (DE-576)372016677 |4 aut | |
| 700 | 1 | |a Kayser, Sabine |d 1979- |e verfasserin |0 (DE-588)138694923 |0 (DE-627)605256233 |0 (DE-576)30778813X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Transfusion medicine and hemotherapy |d Basel : Karger, 2003 |g (2024) online ahead of print |h Online-Ressource |w (DE-627)360670695 |w (DE-600)2100533-3 |w (DE-576)11277542X |x 1660-3818 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g pages:1-4 |g extent:4 |
| 856 | 4 | 0 | |u https://doi.org/10.1159/000534272 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ILN_2013 | ||
| 912 | |a ISIL_DE-16-250 | ||
| 912 | |a SYSFLAG_1 | ||
| 912 | |a GBV_KXP | ||
| 912 | |a GBV_ILN_20 | ||
| 912 | |a GBV_ILN_22 | ||
| 912 | |a GBV_ILN_23 | ||
| 912 | |a GBV_ILN_24 | ||
| 912 | |a GBV_ILN_31 | ||
| 912 | |a GBV_ILN_39 | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_60 | ||
| 912 | |a GBV_ILN_62 | ||
| 912 | |a GBV_ILN_63 | ||
| 912 | |a GBV_ILN_65 | ||
| 912 | |a GBV_ILN_69 | ||
| 912 | |a GBV_ILN_73 | ||
| 912 | |a GBV_ILN_74 | ||
| 912 | |a GBV_ILN_95 | ||
| 912 | |a GBV_ILN_105 | ||
| 912 | |a GBV_ILN_110 | ||
| 912 | |a GBV_ILN_151 | ||
| 912 | |a GBV_ILN_161 | ||
| 912 | |a GBV_ILN_170 | ||
| 912 | |a GBV_ILN_206 | ||
| 912 | |a GBV_ILN_213 | ||
| 912 | |a GBV_ILN_230 | ||
| 912 | |a GBV_ILN_285 | ||
| 912 | |a GBV_ILN_293 | ||
| 912 | |a GBV_ILN_374 | ||
| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_2014 | ||
| 912 | |a GBV_ILN_2018 | ||
| 912 | |a GBV_ILN_2446 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4126 | ||
| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4277 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4325 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4367 | ||
| 912 | |a GBV_ILN_4700 | ||
| 951 | |a AR | ||
| 952 | |j 2024 |h 1-4 |g 4 |y (2024) online ahead of print | ||
| 980 | |2 2013 |1 01 |x DE-16-250 |b 4490073798 |c 00 |f --%%-- |d --%%-- |e --%%-- |j --%%-- |y l01 |z 22-02-24 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 00 |s s |a hd2024 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 01 |s s |0 (DE-627)1410508463 |a wissenschaftlicher Artikel (Zeitschrift) | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 02 |s s |a per_6 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 03 |s s |a s_4 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s p |0 (DE-627)1820644839 |a Silva Bermudez, Lina Susana | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s k |0 (DE-627)1416469052 |a Institut für Transfusionsmedizin und Immunologie | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s s |a pos_1 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 05 |s p |0 (DE-627)1505167345 |a Heidenreich, Daniela | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 05 |s k |0 (DE-627)1416468528 |a III. Medizinische Klinik | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 05 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 05 |s s |a pos_2 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 06 |s p |0 (DE-627)1494239590 |a Klein, Stefan | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 06 |s k |0 (DE-627)1416468528 |a III. Medizinische Klinik | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 06 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 06 |s s |a pos_3 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 07 |s p |0 (DE-627)1447988639 |a Wuchter, Patrick | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 07 |s k |0 (DE-627)1416469052 |a Institut für Transfusionsmedizin und Immunologie | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 07 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 07 |s s |a pos_4 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 08 |s p |0 (DE-627)1442017163 |a Klüter, Harald | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 08 |s k |0 (DE-627)1416469052 |a Institut für Transfusionsmedizin und Immunologie | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 08 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 08 |s s |a pos_5 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 09 |s p |0 (DE-627)1556502656 |a Kayser, Sabine | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 09 |s k |0 (DE-627)1416469052 |a Institut für Transfusionsmedizin und Immunologie | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 09 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 09 |s s |a pos_6 | ||