Phenotypic and Functional Characterization of Natural Killer Cell Receptors in Human and Rhesus macaque / vorgelegt von Md Zahidul Hasan
Activating killer immunoglobulin-like receptors (KIRs) cannot transmit signals directly but through signaling motifs. Since human activating KIRs lack signaling molecules, their transmembrane lysine residue pairs with adaptor proteins like ITAM signaling motif-containing DAP12. KIR2DL4 is an exceptional activating KIR, possesses a transmembrane arginine residue and pairs with ITAM-containing FcRγ (encoded by the FCER1G gene) instead of DAP12. Interestingly, the formation of Rhesus macaque (Rh) activating KIR genes is thought to be due to recombination between the KIR3D and KIR2DL4 genes. He....
| Medienart: |
E-Book |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
Göttingen: 2024 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Hasan, Md Zahidul [VerfasserIn] |
|---|---|
| Hochschulschrift: |
Dissertation, Georg-August-Universität Göttingen, 2024, Kumulative Dissertation |
| Links: |
|---|
| Themen: |
Adaptive NK cell |
|---|
| Umfang: |
1 Online-Ressource ; Illustrationen, Diagramme |
|---|
| Weitere IDs: |
urn:nbn:de:gbv:7-ediss-15105-6 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
1880245523 |
|---|
| LEADER | 01000cam a2200265 4500 | ||
|---|---|---|---|
| 001 | 1880245523 | ||
| 003 | DE-627 | ||
| 005 | 20240208162726.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240207s2024 gw |||||om 00| ||eng c | ||
| 024 | 7 | |a urn:nbn:de:gbv:7-ediss-15105-6 |2 urn | |
| 035 | |a (DE-627)1880245523 | ||
| 035 | |a (DE-599)KXP1880245523 | ||
| 035 | |a (OCoLC)1420216776 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 044 | |c XA-DE-NI | ||
| 082 | 0 | |a 570 |2 22 | |
| 100 | 1 | |a Hasan, Md Zahidul |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Phenotypic and Functional Characterization of Natural Killer Cell Receptors in Human and Rhesus macaque |c vorgelegt von Md Zahidul Hasan |
| 264 | 1 | |a Göttingen |c 2024 | |
| 300 | |a 1 Online-Ressource |b Illustrationen, Diagramme | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 502 | |b Dissertation |c Georg-August-Universität Göttingen |d 2024 |g Kumulative Dissertation | ||
| 520 | |a Activating killer immunoglobulin-like receptors (KIRs) cannot transmit signals directly but through signaling motifs. Since human activating KIRs lack signaling molecules, their transmembrane lysine residue pairs with adaptor proteins like ITAM signaling motif-containing DAP12. KIR2DL4 is an exceptional activating KIR, possesses a transmembrane arginine residue and pairs with ITAM-containing FcRγ (encoded by the FCER1G gene) instead of DAP12. Interestingly, the formation of Rhesus macaque (Rh) activating KIR genes is thought to be due to recombination between the KIR3D and KIR2DL4 genes. He... | ||
| 540 | |2 cc |u http://creativecommons.org/licenses/by/4.0/ | ||
| 650 | 4 | |a Natural Killer cell | |
| 650 | 4 | |a Killer immunoglobulin-like receptor | |
| 650 | 4 | |a C-type lectin-like receptor | |
| 650 | 4 | |a NKG2A | |
| 650 | 4 | |a NKG2C | |
| 650 | 4 | |a HLA-E | |
| 650 | 4 | |a Adaptive NK cell | |
| 650 | 4 | |a Adaptor protein | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Cytomegalovirus | |
| 655 | 7 | |a Hochschulschrift |0 (DE-588)4113937-9 |0 (DE-627)105825778 |0 (DE-576)209480580 |2 gnd-content | |
| 700 | 1 | |a Walter, Lutz |e akademischer betreuerin |4 dgs | |
| 700 | 1 | |a Reichardt, Holger |e akademischer betreuerin |4 dgs | |
| 700 | 1 | |a Behr, Rüdiger |e akademischer betreuerin |4 dgs | |
| 751 | |a Göttingen |0 (DE-588)4021477-1 |0 (DE-627)106313819 |0 (DE-576)20893815X |4 uvp | ||
| 856 | 4 | 0 | |u http://resolver.sub.uni-goettingen.de/purl?ediss-11858/15105 |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://nbn-resolving.org/urn:nbn:de:gbv:7-ediss-15105-6 |x Resolving-System |z kostenfrei |3 Volltext |
| 912 | |a GBV_ILN_40 | ||
| 912 | |a ISIL_DE-7 | ||
| 912 | |a SYSFLAG_1 | ||
| 912 | |a GBV_KXP | ||
| 912 | |a GBV_ILN_2403 | ||
| 912 | |a ISIL_DE-LFER | ||
| 951 | |a BO | ||
| 953 | |2 045F |a 570 | ||
| 980 | |2 40 |1 01 |x 0007 |b 4479166769 |h ediss |y xsn |z 07-02-24 | ||
| 980 | |2 2403 |1 01 |x DE-LFER |b 4495619187 |c 00 |f --%%-- |d --%%-- |e n |j --%%-- |y l01 |z 05-03-24 | ||
| 981 | |2 40 |1 01 |x 0007 |r http://resolver.sub.uni-goettingen.de/purl?ediss-11858/15105 |z LF |3 Volltext | ||
| 981 | |2 2403 |1 01 |x DE-LFER |r http://nbn-resolving.org/urn:nbn:de:gbv:7-ediss-15105-6 | ||
| 995 | |2 40 |1 01 |x 0007 |a ediss | ||