Charakterisierung von BCAS1-positiven Oligodendrozyten während der menschlichen Gehirnentwicklung : = Characterization of BCAS1-positive oligodendrocytes during human brain development / vorgelegt von Linda Böckhaus ; Referent/in: Frau Prof. Dr. med. C. Stadelmann-Nessler, Ko-Referent/in: Frau Prof. Dr. med. J. Gärtner
In der vorliegenden Dissertation wurden Oligodendrozyten in der weißen Substanz des zentralen Nervensystems in verschiedenen Stadien der menschlichen prä- und frühen postnatalen Entwicklung in verschiedenen ZNS-Regionen miteinander verglichen. Der Fokus lag dabei auf BCAS1+ Oligodendrozyten, welche prämyelinisierende beziehungsweise aktiv myelinisierende Oligodendrozyten sind. Es wurde die Hypothese untersucht, dass NG2+ Zellen zu BCAS1+ Zellen differenzieren, welche daraufhin Myelin bilden. Des Weiteren wurde untersucht, ob die Expression von BCAS1 anschließend wieder abnimmt und diese Zel....
This work investigated the comparison between different stages of pre- and early postnatal development of oligodendrocytes in the white matter of the central nervous system. The main focus was to aim at BCAS1+ oligodendrocytes which are both premyelinating and active myelin-forming oligodendrocytes. The main hypothesis was that NG2+ cells differentiate into BCAS1+ cells, then leading to formation of myelin. In addition, the investigation included whether these cells then show a decreasing expression of BCAS1 but an increase in TPPP/p25 expression. Therefore, different regions of the medulla....
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
Göttingen: 2024 |
| Weitere Ausgaben: |
Erscheint auch als Druck-Ausgabe: Charakterisierung von BCAS1-positiven Oligodendrozyten während der menschlichen Gehirnentwicklung |
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| Sprache: |
Deutsch |
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| Weiterer Titel: |
Characterization of BCAS1-positive oligodendrocytes during human brain development |
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| Beteiligte Personen: |
Böckhaus, Linda Selma Elfriede, 1991- [VerfasserIn] |
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| Hochschulschrift: |
| Links: |
Volltext [kostenfrei] |
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| Umfang: |
1 Online-Ressource ; Illustrationen, Diagramme |
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| Weitere IDs: |
urn:nbn:de:gbv:7-ediss-15102-9 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
1880245469 |
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| 245 | 1 | 0 | |a Charakterisierung von BCAS1-positiven Oligodendrozyten während der menschlichen Gehirnentwicklung |b = Characterization of BCAS1-positive oligodendrocytes during human brain development |c vorgelegt von Linda Böckhaus ; Referent/in: Frau Prof. Dr. med. C. Stadelmann-Nessler, Ko-Referent/in: Frau Prof. Dr. med. J. Gärtner |
| 246 | 3 | 1 | |a Characterization of BCAS1-positive oligodendrocytes during human brain development |
| 264 | 1 | |a Göttingen |c 2024 | |
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| 520 | |a In der vorliegenden Dissertation wurden Oligodendrozyten in der weißen Substanz des zentralen Nervensystems in verschiedenen Stadien der menschlichen prä- und frühen postnatalen Entwicklung in verschiedenen ZNS-Regionen miteinander verglichen. Der Fokus lag dabei auf BCAS1+ Oligodendrozyten, welche prämyelinisierende beziehungsweise aktiv myelinisierende Oligodendrozyten sind. Es wurde die Hypothese untersucht, dass NG2+ Zellen zu BCAS1+ Zellen differenzieren, welche daraufhin Myelin bilden. Des Weiteren wurde untersucht, ob die Expression von BCAS1 anschließend wieder abnimmt und diese Zel... | ||
| 520 | |a This work investigated the comparison between different stages of pre- and early postnatal development of oligodendrocytes in the white matter of the central nervous system. The main focus was to aim at BCAS1+ oligodendrocytes which are both premyelinating and active myelin-forming oligodendrocytes. The main hypothesis was that NG2+ cells differentiate into BCAS1+ cells, then leading to formation of myelin. In addition, the investigation included whether these cells then show a decreasing expression of BCAS1 but an increase in TPPP/p25 expression. Therefore, different regions of the medulla... | ||
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| 650 | 4 | |a Myelin | |
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| 650 | 4 | |a Prämyelinisierende Oligodendrozyten | |
| 650 | 4 | |a Weiße Substanz | |
| 650 | 4 | |a oligodendrocyte | |
| 650 | 4 | |a bcas1 | |
| 650 | 4 | |a TPPP/p25 | |
| 650 | 4 | |a myelin | |
| 650 | 4 | |a multiple sclerosis | |
| 650 | 4 | |a brain development | |
| 650 | 4 | |a oligodendrocyte precursor cells | |
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| 650 | 4 | |a white matter | |
| 650 | 4 | |a premyelinating oligodendrocytes | |
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