Pharmacogenomics in Clinical Practice
Intro -- Contents -- Principles of Pharmacogenetics -- 1 Introduction -- 2 The Significance of Pharmacogenetics in the Context of Personalized (Precision) Medicine -- 3 Influence of Genetic Inter-individual Variations on Therapeutic Outcomes -- 4 Gene/Drug Interaction-Level of Evidence for the Development of Pharmacotherapeutic Guidelines -- 5 Conclusion -- References -- Principles of Xenobiotic Metabolism (Biotransformation) -- 1 Introduction -- 2 Oxidations -- 2.1 Cytochrome P450 -- 2.2 Alcohol and Aldehyde Dehydrogenases -- 2.3 Peroxidases -- 2.4 Xanthine Oxidoreductase and Aldehyde Oxidase -- 2.5 Flavin-Containing Monooxygenase -- 2.6 Monoamine Oxidase -- 3 Reductions -- 4 Hydrolysis and Conjugations -- 4.1 Hydrolysis -- 4.2 Glucuronidation -- 4.3 Sulfoconjugation -- 4.4 Methylation -- 4.5 Acetylation -- 4.6 Conjugation with Amino Acids -- 4.7 Conjugation with Glutathione -- 5 Metabolic Reactions in Therapeutic Drug Monitoring -- References -- Pharmacogenomics of Drug-Metabolizing Enzymes -- 1 Introduction -- 2 Enzymes Involved in Phase I Drug Metabolism -- 2.1 CYP2D6 -- 2.2 CYP2C19 -- 2.3 CYP2C9 -- 2.4 CYP3A4/A5 -- 2.5 Other Isoforms of Cytochrome CYP P450 Enzyme System (CYP1A2, 2A6, 2B6, 4F2) -- 3 Enzymes Involved in Phase II Drug Metabolism -- 3.1 Thiopurine Methyltransferase-TPMT -- 3.2 N-acetyltransferase 2-NAT2 -- 3.3 Glutathione S-transferase-GSTM1, GSTT1, GSTP1 -- 3.4 UDP Glucuronyl Transferase-UGT1A1 -- 3.5 Sulfotransferase-SULT -- 4 Vitamin K Epoxy Reductase-VKORC1 -- 5 Pharmacogenetic profile of CYP2C9 and VKORC1 in anticoagulant therapy -- 6 Conclusion -- References -- Role of Membrane Transporters in Pharmacogenomics -- 1 Introduction -- 2 ABC Superfamily -- 2.1 ABCB1 (P-gp, from P-Glycoprotein -- MDR1, from Multidrug Resistance Protein) -- 2.2 ABCG2 (BCRP, from the Breast Cancer Resistance Protein, also Known as MXR or MCF-7)..
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
2024 ©2023 |
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| Erschienen: |
Cham: Springer International Publishing AG ; 2024 ©2023 |
| Ausgabe: |
1st edition |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Primorac, Dragan [HerausgeberIn] |
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| Links: |
ebookcentral.proquest.com [lizenzpflichtig] |
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| ISBN: |
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| Anmerkungen: |
Description based on publisher supplied metadata and other sources |
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| Umfang: |
1 Online-Ressource (484 Seiten) |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
1879493454 |
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| 520 | |a Intro -- Contents -- Principles of Pharmacogenetics -- 1 Introduction -- 2 The Significance of Pharmacogenetics in the Context of Personalized (Precision) Medicine -- 3 Influence of Genetic Inter-individual Variations on Therapeutic Outcomes -- 4 Gene/Drug Interaction-Level of Evidence for the Development of Pharmacotherapeutic Guidelines -- 5 Conclusion -- References -- Principles of Xenobiotic Metabolism (Biotransformation) -- 1 Introduction -- 2 Oxidations -- 2.1 Cytochrome P450 -- 2.2 Alcohol and Aldehyde Dehydrogenases -- 2.3 Peroxidases -- 2.4 Xanthine Oxidoreductase and Aldehyde Oxidase -- 2.5 Flavin-Containing Monooxygenase -- 2.6 Monoamine Oxidase -- 3 Reductions -- 4 Hydrolysis and Conjugations -- 4.1 Hydrolysis -- 4.2 Glucuronidation -- 4.3 Sulfoconjugation -- 4.4 Methylation -- 4.5 Acetylation -- 4.6 Conjugation with Amino Acids -- 4.7 Conjugation with Glutathione -- 5 Metabolic Reactions in Therapeutic Drug Monitoring -- References -- Pharmacogenomics of Drug-Metabolizing Enzymes -- 1 Introduction -- 2 Enzymes Involved in Phase I Drug Metabolism -- 2.1 CYP2D6 -- 2.2 CYP2C19 -- 2.3 CYP2C9 -- 2.4 CYP3A4/A5 -- 2.5 Other Isoforms of Cytochrome CYP P450 Enzyme System (CYP1A2, 2A6, 2B6, 4F2) -- 3 Enzymes Involved in Phase II Drug Metabolism -- 3.1 Thiopurine Methyltransferase-TPMT -- 3.2 N-acetyltransferase 2-NAT2 -- 3.3 Glutathione S-transferase-GSTM1, GSTT1, GSTP1 -- 3.4 UDP Glucuronyl Transferase-UGT1A1 -- 3.5 Sulfotransferase-SULT -- 4 Vitamin K Epoxy Reductase-VKORC1 -- 5 Pharmacogenetic profile of CYP2C9 and VKORC1 in anticoagulant therapy -- 6 Conclusion -- References -- Role of Membrane Transporters in Pharmacogenomics -- 1 Introduction -- 2 ABC Superfamily -- 2.1 ABCB1 (P-gp, from P-Glycoprotein -- MDR1, from Multidrug Resistance Protein) -- 2.2 ABCG2 (BCRP, from the Breast Cancer Resistance Protein, also Known as MXR or MCF-7). | ||
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