Natural Product-Based Synthetic Drug Molecules in Alzheimer's Disease : Therapeutic and Theranostic Agents

Intro -- Preface -- Contents -- Editors and Contributors -- Part I: Introduction of Alzheimer´s Disease -- 1: Alzheimer´s Disease and Drug Targets -- 1.1 Introduction -- 1.2 Pathological and Therapeutic Target in AD -- 1.2.1 Amyloid Beta (Aβ) -- 1.2.2 Tau Phosphorylation -- 1.3 Mitochondrial Dysfunction and Oxidative Stress in Alzheimer´s Disease -- 1.3.1 Alzheimer´s Disease Drug Targets -- 1.3.1.1 Prevention of Aβ Accumulation and Amyloid Inhibitors -- 1.3.1.2 Prevention of Tau Protein Phosphorylation -- 1.3.1.3 MicroRNAs in the Management of AD -- 1.3.1.4 Pyroglutamate Aβ Cascade as a Potential Target -- 1.3.1.5 Immunotherapy in Alzheimer´s Disease -- References -- 2: Oxidative Stress and Metals in Alzheimer´s Disease -- 2.1 Introduction -- 2.2 Oxidative Stress -- 2.2.1 Oxidative Stress and Neurodegeneration -- 2.2.2 Relation Between Oxygen and Oxidative Stress -- 2.2.3 Mechanism of Generation of Reactive Oxygen Species (ROS) -- 2.2.4 Role of Amyloid Beta (Aβ)-Induced Oxidative Stress in Alzheimer´s Disease (AD) -- 2.2.5 Oxidative Damage-Induced Tau Neurofibrillary Tangles -- 2.3 ROS-Induced Disruption of Calcium Signalling in Alzheimer´s Disease -- 2.4 ROS-Induced Mitochondrial Dysfunction (Mitochondrial Cascade Hypothesis) -- 2.5 Oxidative Stress and Damage to Biomolecules (Lipids, Proteins, DNA/RNA) -- 2.6 Role of Metals in AD -- 2.7 Zinc -- 2.8 Iron Toxicity -- 2.9 Copper Toxicity -- 2.10 Aluminium -- 2.11 Manganese -- 2.12 Cadmium -- 2.13 Lead -- 2.14 Conclusion -- References -- 3: Neuroinflammation in Alzheimer´s Disease -- 3.1 Introduction -- 3.2 Epidemiology -- 3.3 Neuroinflammation -- 3.3.1 Etiology -- 3.4 Mechanism of Neuroinflammation in AD -- 3.4.1 Microglial Activation -- 3.4.1.1 MyD88-Dependent Pathways -- 3.4.1.2 Activation of MyD88-Independent Pathways -- 3.4.2 Activation of Astrocytes -- 3.4.3 Damage to Cell Membrane..

Medienart:	E-Book

Erscheinungsjahr:	2024 ©2023
Erschienen:	Singapore: Springer ; 2024 ©2023
Ausgabe:	1st edition

Sprache:	Englisch

Beteiligte Personen:	Sharma, Abha [HerausgeberIn] Modi, Gyan Prakash [HerausgeberIn]

Links:	ebookcentral.proquest.com [lizenzpflichtig]

ISBN:	978-981-99-6038-5

Anmerkungen:	Description based on publisher supplied metadata and other sources

Umfang:	1 Online-Ressource (447 Seiten)

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1879435004