Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain [data] / Sebstián Marty-Lombardi, Shiying Lu, Wojciech Ambroziak, Katrin Schrenk-Siemens, Jialin Wang, Anna A. DePaoli-Roach, Anna M. Hagenston, Hagen Wende, Anke Tappe-Theodor, Manuela Simonetti, Hilmar Bading, Jürgen G. Okun, Rohini Kuner, Thomas Fleming, Jan Siemens
Long-lasting pain stimuli can trigger maladaptive changes in the spinal cord, reminiscent of plasticity associated with memory formation. Metabolic coupling between astrocytes and neurons has been implicated in neuronal plasticity and memory formation in the CNS, but neither its involvement in pathological pain nor in spinal plasticity has been tested. Here, we report a form of neuroglia signaling involving spinal astrocytic glycogen dynamics triggered by persistent noxious stimulation via upregulation of the Protein Targeting to Glycogen (PTG) in spinal astrocytes. PTG drove glycogen build-up in astrocytes, and blunting glycogen accumulation and turnover by Ptg gene deletion reduced pain-related behaviors and promoted faster recovery by shortening pain maintenance in mice. Furthermore, mechanistic analyses revealed that glycogen dynamics is a critically required process for maintenance of pain by facilitating neuronal plasticity in spinal lamina 1 neurons. In summary, our study describes a previously unappreciated mechanism of astrocyte-neuron metabolic communication through glycogen breakdown in the spinal cord that fuels spinal neuron hyperexcitability. (2024-01-23).
| Medienart: |
E-Zeitschrift |
|---|
| Erscheinungsjahr: |
2024-01-26 |
|---|---|
| Erschienen: |
Heidelberg: Universität ; 2024-01-26 |
| Weitere Ausgaben: |
Forschungsdaten zu: Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Marty-Lombardi, Sebastián [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Gesehen am 29.01.2024 |
|---|
| Umfang: |
1 Online-Ressource (2 Files) |
|---|
| doi: |
10.11588/data/AMDH7G |
|---|---|
| Weitere IDs: |
DFG SFB1158 ERC-CoG-772395 HFSP LT000762/2019-L |
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
1879397498 |
|---|
| LEADER | 01000cmi a2200265 4500 | ||
|---|---|---|---|
| 001 | 1879397498 | ||
| 003 | DE-627 | ||
| 005 | 20240306075732.0 | ||
| 006 | su| d|o |0 |0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240129s2024 xx |o | eng c | ||
| 024 | 7 | |a 10.11588/data/AMDH7G |2 doi | |
| 024 | 8 | |a DFG SFB1158 |q Grantnumber | |
| 024 | 8 | |a ERC-CoG-772395 |q Grantnumber | |
| 024 | 8 | |a HFSP LT000762/2019-L |q Grantnumber | |
| 035 | |a (DE-627)1879397498 | ||
| 035 | |a (DE-599)KXP1879397498 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 100 | 1 | |a Marty-Lombardi, Sebastián |e verfasserin |0 (DE-588)1317475631 |0 (DE-627)187939801X |4 aut | |
| 245 | 1 | 0 | |a Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain [data] |c Sebstián Marty-Lombardi, Shiying Lu, Wojciech Ambroziak, Katrin Schrenk-Siemens, Jialin Wang, Anna A. DePaoli-Roach, Anna M. Hagenston, Hagen Wende, Anke Tappe-Theodor, Manuela Simonetti, Hilmar Bading, Jürgen G. Okun, Rohini Kuner, Thomas Fleming, Jan Siemens |
| 264 | 1 | |a Heidelberg |b Universität |c 2024-01-26 | |
| 300 | |a 1 Online-Ressource (2 Files) | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 336 | |a Computerdaten |b cod |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.01.2024 | ||
| 520 | |a Long-lasting pain stimuli can trigger maladaptive changes in the spinal cord, reminiscent of plasticity associated with memory formation. Metabolic coupling between astrocytes and neurons has been implicated in neuronal plasticity and memory formation in the CNS, but neither its involvement in pathological pain nor in spinal plasticity has been tested. Here, we report a form of neuroglia signaling involving spinal astrocytic glycogen dynamics triggered by persistent noxious stimulation via upregulation of the Protein Targeting to Glycogen (PTG) in spinal astrocytes. PTG drove glycogen build-up in astrocytes, and blunting glycogen accumulation and turnover by Ptg gene deletion reduced pain-related behaviors and promoted faster recovery by shortening pain maintenance in mice. Furthermore, mechanistic analyses revealed that glycogen dynamics is a critically required process for maintenance of pain by facilitating neuronal plasticity in spinal lamina 1 neurons. In summary, our study describes a previously unappreciated mechanism of astrocyte-neuron metabolic communication through glycogen breakdown in the spinal cord that fuels spinal neuron hyperexcitability. (2024-01-23) | ||
| 655 | 7 | |a Forschungsdaten |0 (DE-588)1098579690 |0 (DE-627)857755366 |0 (DE-576)469182156 |2 gnd-content | |
| 655 | 7 | |a Datenbank |0 (DE-588)4011119-2 |0 (DE-627)106354256 |0 (DE-576)208891943 |2 gnd-content | |
| 700 | 1 | |a Lu, Shiying |e verfasserin |0 (DE-588)1153417170 |0 (DE-627)1014830567 |0 (DE-576)500216363 |4 aut | |
| 700 | 1 | |a Ambroziak, Wojciech |e verfasserin |0 (DE-588)1237018765 |0 (DE-627)1762888181 |4 aut | |
| 700 | 1 | |a Schrenk-Siemens, Katrin |e verfasserin |0 (DE-588)1067334319 |0 (DE-627)818630248 |0 (DE-576)426566807 |4 aut | |
| 700 | 1 | |a Wang, Jialin |d 1987- |e verfasserin |0 (DE-588)1077387156 |0 (DE-627)836456823 |0 (DE-576)446258938 |4 aut | |
| 700 | 1 | |a DePaoli-Roach, Anna A. |e verfasserin |4 aut | |
| 700 | 1 | |a Hertle, Anna M. |e verfasserin |0 (DE-588)1033242705 |0 (DE-627)740374338 |0 (DE-576)38082504X |4 aut | |
| 700 | 1 | |a Wende, Hagen |d 1974- |e verfasserin |0 (DE-588)129288446 |0 (DE-627)392392127 |0 (DE-576)297580396 |4 aut | |
| 700 | 1 | |a Tappe-Theodor, Anke |d 1974- |e verfasserin |0 (DE-588)132571803 |0 (DE-627)523955537 |0 (DE-576)299232883 |4 aut | |
| 700 | 1 | |a Simonetti, Manuela |e verfasserin |0 (DE-588)103324256X |0 (DE-627)740374060 |0 (DE-576)380824582 |4 aut | |
| 700 | 1 | |a Bading, Hilmar |d 1958- |e verfasserin |0 (DE-588)1017989680 |0 (DE-627)690486553 |0 (DE-576)170837947 |4 aut | |
| 700 | 1 | |a Okun, Jürgen G. |d 1968- |e verfasserin |0 (DE-588)121578232 |0 (DE-627)705551415 |0 (DE-576)292781296 |4 aut | |
| 700 | 1 | |a Kuner, Rohini |d 1970- |e verfasserin |0 (DE-588)1033243426 |0 (DE-627)741191393 |0 (DE-576)250796732 |4 aut | |
| 700 | 1 | |a Fleming, Thomas |d 1982- |e verfasserin |0 (DE-588)1034445294 |0 (DE-627)745607365 |0 (DE-576)382066804 |4 aut | |
| 700 | 1 | |a Siemens, Jan |e verfasserin |0 (DE-588)1067334610 |0 (DE-627)818630752 |0 (DE-576)426567323 |4 aut | |
| 787 | 0 | 8 | |i Forschungsdaten zu |a Marty-Lombardi, Sebastián |t Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain |d 2024 |w (DE-627)1882585313 |
| 856 | 4 | 0 | |u https://doi.org/10.11588/data/AMDH7G |x Resolving-System |x Verlag |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://heidata.uni-heidelberg.de/dataset.xhtml?persistentId=doi:10.11588/data/AMDH7G |x Verlag |z kostenfrei |3 Volltext |
| 912 | |a GBV_ILN_2011 | ||
| 912 | |a ISIL_DE-16 | ||
| 912 | |a SYSFLAG_1 | ||
| 912 | |a GBV_KXP | ||
| 912 | |a GBV_ILN_2013 | ||
| 912 | |a ISIL_DE-16-250 | ||
| 912 | |a GBV_ILN_2403 | ||
| 912 | |a ISIL_DE-LFER | ||
| 951 | |a BO | ||
| 980 | |2 2011 |1 01 |x DE-16 |b 4471869043 |c 00 |f --%%-- |d --%%-- |e --%%-- |j --%%-- |y l01 |z 29-01-24 | ||
| 980 | |2 2013 |1 01 |x DE-16-250 |b 4471845632 |c 00 |f --%%-- |d --%%-- |e --%%-- |j --%%-- |y l01 |z 29-01-24 | ||
| 980 | |2 2403 |1 01 |x DE-LFER |b 4478585784 |c 00 |f --%%-- |d --%%-- |e n |j --%%-- |y l01 |z 07-02-24 | ||
| 981 | |2 2403 |1 01 |x DE-LFER |r https://doi.org/10.11588/data/AMDH7G | ||
| 981 | |2 2403 |1 01 |x DE-LFER |r https://heidata.uni-heidelberg.de/dataset.xhtml?persistentId=doi:10.11588/data/AMDH7G | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 00 |s s |a hd2024 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 01 |s s |0 (DE-627)1477498621 |a Forschungsdaten | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 02 |s s |a per_15 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 03 |s s |a s_2 Files | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s p |0 (DE-627)1879399318 |a Marty-Lombardi, Sebastián | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s k |0 (DE-627)1416822720 |a Extern | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s s |a pos_1 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 05 |s p |0 (DE-627)157021624X |a Lu, Shiying | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 05 |s k |0 (DE-627)1416535500 |a Fakultät für Biowissenschaften | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 05 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 05 |s s |a pos_2 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 06 |s p |0 (DE-627)1762888335 |a Ambroziak, Wojciech | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 06 |s k |0 (DE-627)1416822720 |a Extern | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 06 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 06 |s s |a pos_3 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 07 |s p |0 (DE-627)1496567080 |a Schrenk-Siemens, Katrin | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 07 |s k |0 (DE-627)1416742069 |a Pharmakologisches Institut | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 07 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 07 |s s |a pos_4 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 08 |s p |0 (DE-627)1879624281 |a Wang, Jialin | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 08 |s k |0 (DE-627)1416742069 |a Pharmakologisches Institut | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 08 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 08 |s s |a pos_5 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 09 |s p |0 (DE-627)1450825370 |a Hertle, Anna M. | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 09 |s k |0 (DE-627)1416528504 |a IZN Neurobiologie | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 09 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 09 |s s |a pos_7 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 10 |s p |0 (DE-627)149656720X |a Tappe-Theodor, Anke | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 10 |s k |0 (DE-627)1416742069 |a Pharmakologisches Institut | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 10 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 10 |s s |a pos_9 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 11 |s p |0 (DE-627)1450825338 |a Simonetti, Manuela | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 11 |s k |0 (DE-627)1416535500 |a Fakultät für Biowissenschaften | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 11 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 11 |s s |a pos_10 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 12 |s p |0 (DE-627)1416795464 |a Bading, Hilmar | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 12 |s k |0 (DE-627)1416528504 |a IZN Neurobiologie | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 12 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 12 |s s |a pos_11 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 13 |s p |0 (DE-627)148007991X |a Okun, Jürgen G. | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 13 |s k |0 (DE-627)1416740988 |a Zentrum für Kinder- und Jugendmedizin | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 13 |s k |0 (DE-627)1416466967 |a Medizinische Fakultät Heidelberg | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 13 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 13 |s s |a pos_12 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 14 |s p |0 (DE-627)1450826857 |a Kuner, Rohini | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 14 |s k |0 (DE-627)1416742069 |a Pharmakologisches Institut | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 14 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 14 |s s |a pos_13 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 15 |s p |0 (DE-627)1464383596 |a Fleming, Thomas | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 15 |s k |0 (DE-627)169133667X |a Zentrum für Innere Medizin (Krehl Klinik) | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 15 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 15 |s s |a pos_14 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 16 |s p |0 (DE-627)1496567439 |a Siemens, Jan | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 16 |s k |0 (DE-627)1416742069 |a Pharmakologisches Institut | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 16 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 16 |s s |a pos_15 | ||