Molecular Recognition in Pharmacology

Cover -- Half Title -- Series Information -- Title Page -- Copyright Page -- Table of Contents -- Preface -- Note -- Acknowledgments -- Author -- Acronyms and Abbreviations -- Introduction: Molecular Recognition and New Drug Development: Extracts from Conducted Studies -- 1 Energy of Interactions in Drug-receptor Complex Formation -- 1.1 Properties of Complexes -- 1.2 Equations Used to Calculate the Energy of Intermolecular Interactions -- 1.3 Ion-ion Interaction -- 1.3.1 Cationic Groups in Drugs -- 1.3.2 Anionic Groups in Drugs -- 1.4 Ionization Constants -- 1.5 Effect of Substituting Groups in Molecules on Ionization: Inductive and Mesomeric Effects -- 1.6 Ion-dipole Interaction -- 1.7 Dipole-dipole Interaction -- 1.8 Hydrogen Bonding -- 1.9 Ion-induced Dipole Interaction -- 1.10 Dipole-induced Dipole Interaction -- 1.11 Charge Transfer Complex -- 1.12 Dispersion Interactions -- 1.13 Hydrophobic Interactions -- 1.14 Covalent Bonding -- 1.15 Short-range Repulsive Forces -- 1.16 Dielectric Constant -- 1.17 Hydration of Molecules -- 1.18 Relationship of Energy Components in Different Types of Interaction -- Note -- References -- 2 Methods for Studying Drug-receptor Binding -- 2.1 Introduction -- 2.2 Determination of Equilibrium Constants of Ligand-receptor Binding -- 2.3 Methods for the Analysis of Ligand-receptor Interactions: Types of Antagonism -- 2.4 Pharmacological Methods for Determining Kd and the Antagonism Type -- 2.5 Comparison of Radioligand and Pharmacological Methods of Kd Determination -- 2.6 Determination of the Rate Constants of Ligand-receptor Binding -- 2.7 Competitive Methods to Determine the Rate Constants of Ligand-receptor Binding -- 2.8 Relaxation Methods for Determining the Rate Constants -- 2.9 Methods for the Study of Conformational Kinetics in a Ligand-receptor Complex -- References..

Medienart:	E-Book

Erscheinungsjahr:	2023 ©2024
Erschienen:	Milton: Taylor & Francis Group ; 2023 ©2024

Reihe:	Drugs and the Pharmaceutical Sciences Series

Sprache:	Englisch

Beteiligte Personen:	Darkhovskiy, Mikhail [VerfasserIn]

Links:	ebookcentral.proquest.com [lizenzpflichtig]

ISBN:	978-1-000-99922-8

Themen:	Drugs-Reactivity Molecular pharmacology Molecular recognition

Anmerkungen:	Description based on publisher supplied metadata and other sources

Umfang:	1 Online-Ressource (205 Seiten)

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1870029615