Details der Publikation - Single versus bilateral external ventricular drainage for intraventricular fibrinolysis in severe ventricular haemorrhage

Single versus bilateral external ventricular drainage for intraventricular fibrinolysis in severe ventricular haemorrhage / D. Staykov, H. B. Huttner, J. Lunkenheimer, B. Volbers, T. Struffert, A. Doerfler, O. Ganslandt, E. Juettler, S. Schwab, J. Bardutzky

BACKGROUND: Intraventricular fibrinolysis (IVF) through bilateral external ventricular drains (EVD) may provide better access of the thrombolytic agent to the intraventricular clot, potentially influencing clot clearance and outcome. - METHODS: Patients with spontaneous ganglionic intracerebral haemorrhage (ICH)<40 cm(3) and intraventricular haemorrhage (IVH) with acute hydrocephalus have been treated with IVF. The decision for placement of one or two EVDs has been left to the discretion of the treating physician. CT volumetry, the effects on cerebrospinal fluid (CSF) circulation and outcome at 3 months have been analysed for patients with one (group I, n = 13) or two EVDs (group II, n = 14). - RESULTS: No difference was found in clot resolution between the two groups (clot half life 2.1 (SD 1.2) vs 2.4 (1.3) days). A separate analysis of the third and fourth ventricle clearance was similar (1.6 (0.6) versus 1.8 (0.8) days), indicating no difference in reconstitution of CSF circulation. A trend towards a longer EVD duration and higher infection rate was found in the bilateral EVD group. No difference was found in outcome at 3 months. - CONCLUSIONS: Our results do not support the use of bilateral EVDs for IVF in patients with severe IVH..

Medienart:	E-Artikel

Erscheinungsjahr:	2010 Jan 2010
Erschienen:	2010 Jan

Enthalten in:	Zur Gesamtaufnahme - volume:81
Enthalten in:	Journal of neurology, neurosurgery, and psychiatry - 81(2010), 1, Seite 105-108

Sprache:	Englisch

Beteiligte Personen:	Staykov, Dimitre, 1976- [VerfasserIn] Huttner, H. B. [VerfasserIn] Lunkenheimer, J. [VerfasserIn] Volbers, B. [VerfasserIn] Struffert, T. [VerfasserIn] Doerfler, A. [VerfasserIn] Ganslandt, O. [VerfasserIn] Jüttler, Eric, 1972- [VerfasserIn] Schwab, S. [VerfasserIn] Bardutzky, Jürgen, 1970- [VerfasserIn]

Themen:	Cerebral Hemorrhage Cerebrospinal Fluid Shunts Drainage Fibrinolytic Agents Hematoma Humans Injections, Intraventricular Middle Aged Tomography, X-Ray Computed Treatment Outcome

Anmerkungen:	Gesehen am 27.10.2023

Umfang:	4

doi:	10.1136/jnnp.2008.168427

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	186856388X

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245	1	0	\|a Single versus bilateral external ventricular drainage for intraventricular fibrinolysis in severe ventricular haemorrhage \|c D. Staykov, H. B. Huttner, J. Lunkenheimer, B. Volbers, T. Struffert, A. Doerfler, O. Ganslandt, E. Juettler, S. Schwab, J. Bardutzky
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520			\|a BACKGROUND: Intraventricular fibrinolysis (IVF) through bilateral external ventricular drains (EVD) may provide better access of the thrombolytic agent to the intraventricular clot, potentially influencing clot clearance and outcome. - METHODS: Patients with spontaneous ganglionic intracerebral haemorrhage (ICH)<40 cm(3) and intraventricular haemorrhage (IVH) with acute hydrocephalus have been treated with IVF. The decision for placement of one or two EVDs has been left to the discretion of the treating physician. CT volumetry, the effects on cerebrospinal fluid (CSF) circulation and outcome at 3 months have been analysed for patients with one (group I, n = 13) or two EVDs (group II, n = 14). - RESULTS: No difference was found in clot resolution between the two groups (clot half life 2.1 (SD 1.2) vs 2.4 (1.3) days). A separate analysis of the third and fourth ventricle clearance was similar (1.6 (0.6) versus 1.8 (0.8) days), indicating no difference in reconstitution of CSF circulation. A trend towards a longer EVD duration and higher infection rate was found in the bilateral EVD group. No difference was found in outcome at 3 months. - CONCLUSIONS: Our results do not support the use of bilateral EVDs for IVF in patients with severe IVH.
650		4	\|a Cerebral Hemorrhage
650		4	\|a Cerebrospinal Fluid Shunts
650		4	\|a Drainage
650		4	\|a Fibrinolytic Agents
650		4	\|a Hematoma
650		4	\|a Humans
650		4	\|a Injections, Intraventricular
650		4	\|a Middle Aged
650		4	\|a Tomography, X-Ray Computed
650		4	\|a Treatment Outcome
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Single versus bilateral external ventricular drainage for intraventricular fibrinolysis in severe ventricular haemorrhage / D. Staykov, H. B. Huttner, J. Lunkenheimer, B. Volbers, T. Struffert, A. Doerfler, O. Ganslandt, E. Juettler, S. Schwab, J. Bardutzky

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