Rapid antigen tests for SARS-CoV-2 : a synopsis of the medical evidence / Christoph Wertenauer, Caroline Pfeifer, Martin Roskos, Winfried März
SARS-CoV-2, the causative agent of the COVID-19 pandemic, continues to influence health, economy, and stability worldwide. Diagnostic testing for SARS-CoV-2 is important to contain the COVID-19 pandemic. With the commercial availability of certified antigen (Ag) rapid diagnostic tests (RDTs), which can be used to identify an infection with SARS-CoV-2 an easy-to-use tool was introduced. Self-tests can offer advantages to complement professionally administered rapid antigen detection or nucleic acid amplification testing (NAAT). Compared to real-time polymerase chain reaction (RT-PCR), Ag-RDTs are cost inexpensive, do not need specialized laboratory equipment, facilitating high-throughput testing. However, Ag-RDT sensitivities are strongly dependent on the viral load within the specimen, which has limited their application in clinical settings so far. The methodical limitations of Ag-RDTs may produce false negative test results, particularly when specimens with low viral loads are examined. This may facilitate viral transmissions if protective measurements are lifted mistakenly..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
October 2023 2023 |
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| Erschienen: |
October 2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:107 |
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| Enthalten in: |
Diagnostic microbiology and infectious disease - 107(2023), 2 vom: Okt., Artikel-ID 116027, Seite 1-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wertenauer, Christoph [VerfasserIn] |
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| Links: |
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| Themen: |
Antigen test |
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| Anmerkungen: |
Online veröffentlicht am 14. Juli 2023, Artikelversion vom 27. Juli 2023 Gesehen am 20.12.2023 |
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| Umfang: |
Illustrationen 6 |
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| doi: |
10.1016/j.diagmicrobio.2023.116027 |
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| 520 | |a SARS-CoV-2, the causative agent of the COVID-19 pandemic, continues to influence health, economy, and stability worldwide. Diagnostic testing for SARS-CoV-2 is important to contain the COVID-19 pandemic. With the commercial availability of certified antigen (Ag) rapid diagnostic tests (RDTs), which can be used to identify an infection with SARS-CoV-2 an easy-to-use tool was introduced. Self-tests can offer advantages to complement professionally administered rapid antigen detection or nucleic acid amplification testing (NAAT). Compared to real-time polymerase chain reaction (RT-PCR), Ag-RDTs are cost inexpensive, do not need specialized laboratory equipment, facilitating high-throughput testing. However, Ag-RDT sensitivities are strongly dependent on the viral load within the specimen, which has limited their application in clinical settings so far. The methodical limitations of Ag-RDTs may produce false negative test results, particularly when specimens with low viral loads are examined. This may facilitate viral transmissions if protective measurements are lifted mistakenly. | ||
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