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|a Viral vectors in cancer immunotherapy
|c edited by Fernando Aranda, Pedro Berraondo, Lorenzo Galluzzi
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|a [S.l.]
|b Academic Press
|c 2023
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|a International review of cell and molecular biology
|v volume 379
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|a Front Cover -- Series page -- International Review of CELL AND MOLECULARBIOLOGY -- Copyright -- Contents -- Contributors -- Chapter One: Viral vectors engineered for gene therapy -- 1 Introduction -- 2 Viral vectors for gene therapy -- 3 Gene therapy applications using viral vectors -- 3.1 Cancer therapy -- 3.2 Cardiovascular and metabolic diseases -- 3.3 Hematological diseases -- 3.4 Neurological disorders -- 3.5 Muscular diseases -- 3.6 Immunodeficiency -- 3.7 Infectious diseases -- 3.8 Other diseases -- 4 Challenges for viral vector-based gene therapy -- 5 Conclusions and perspectives -- References -- Chapter Two: Checkpoint blockade meets gene therapy: Opportunities to improve response and reduce toxicityCheckpoint blockade meets gene therapy -- 1 Introduction -- 2 Immune checkpoints in cancer immunotherapy -- 3 Types of antibodies used in cancer immunotherapy -- 4 Local delivery of immune checkpoint inhibitors: Prospects for gene therapy -- 5 Oncolytic viruses expressing ICIs -- 6 Non-oncolytic vectors expressing ICIs -- 7 Self-amplifying RNA vectors expressing ICIs -- 8 Combination of vectors expressing ICIs with other therapies -- 8.1 Combination with systemically administered ICIs -- 8.2 Combination with CAR-T cells -- 8.3 Combination with depletion of immunosuppressive cells -- 8.4 Combination with radiation and chemotherapy -- 9 Conclusions -- Competing interests -- Acknowledgements -- References -- Chapter Three: Armored modified vaccinia Ankara in cancer immunotherapy -- 1 Introduction -- 2 MVA as potent immune activator -- 2.1 Cell and tissue tropism -- 2.2 Innate immune activation -- 2.3 Induction of cell death -- 2.4 Generation of adaptive immune responses -- 3 Tumor antigens encoded in MVA vaccines -- 3.1 HER2 -- 3.2 P53 -- 3.3 Brachyury -- 3.4 5T4 -- 3.5 MUC1 and CEA -- 3.6 Self- and virus-derived neoantigens.
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|a 3.7 Novel TAA candidates -- 4 MVA cancer vaccines expressing immune modulatory molecules -- 4.1 MVA-TRICOM -- 4.2 MVA-CD40L -- 4.3 MVA-IL-2 -- 4.4 Novel candidates -- 5 Maximizing MVA cancer vaccine effectiveness: A comprehensive exploration of delivery routes -- 5.1 Alternative immunization routes to enhance MVA-based immune modulation -- 5.2 The impact of immunization routes on the efficacy of armed MVA -- 6 Conclusions and outlook -- References -- Chapter Four: Alphaviruses in cancer immunotherapyAlphaviruses in cancer immunotherapy -- 1 Introduction -- 2 Alphavirus vectors -- 2.1 Recombinant particles -- 2.2 Oncolytic alphaviruses -- 2.3 RNA replicon vectors -- 2.4 DNA replicon vectors -- 3 Alphavirus-based cancer therapy -- 3.1 Antitumor, cytotoxic, and suicide genes -- 3.2 Cancer vaccines -- 3.3 Cancer immunotherapy -- 3.4 Oncolytic alphaviruses -- 4 Alphaviruses in comparison to other approaches -- 4.1 Conventional non-viral vectors versus self-replicating alphavirus DNA vectors -- 4.2 Other viral vectors versus recombinant self-replicating alphavirus particles -- 4.3 Synthetic mRNA molecules versus self-replicating RNA replicons -- 5 Conclusions -- References -- Chapter Five: Oncolytic viruses as treatment for adult and pediatric high-grade gliomas: On the way to clinical successOncolytic viruses as treatment for adult and pediatric high-grade gliomas -- 1 High-grade gliomas -- 2 Oncolytic viruses -- 3 Adult high-grade glioma clinical trials -- 3.1 Herpes simplex virus type-1(HSV-1) -- 3.2 Adenoviruses -- 3.3 Other oncolytic viruses -- 4 Pediatric high-grade glioma clinical trials -- 5 Discussion and future perspectives -- References -- Chapter Six: Oncolytic viruses in hematological malignancies: hijacking disease biology and fostering new promises for immune and cell-based therapiesOncolytic viruses in hematological malignancies.
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|a 1 Introduction -- 2 Families of oncolytic viruses and mechanisms of action -- 2.1 General biology of viruses -- 2.2 Family of viruses with potential application in oncolytic therapy -- 2.3 Virotherapy principles: cell signaling and immunopathogenesis in viral infection response -- 2.4 Viral oncolytic strategies, cell signaling disruption, and immune reprogramming -- 3 Virotherapy approaches in hematological malignancies -- 3.1 Precursor myeloid malignancies -- 3.2 Precursor lymphoid malignancies -- 3.3 Myeloproliferative neoplasms -- 3.4 Mature lymphoid malignancies -- 3.4.1 B cell-derived malignancies -- 3.4.2 T cell-derived malignancies -- 3.5 Multiple myeloma -- 3.6 Combinatorial strategies to enhance immunogenic cell death -- 4 Conclusion -- References -- Chapter Seven: Oncolytic virotherapy in lung cancerOncolytic virotherapy in lung cancer -- 1 The lung cancer scenario -- 2 Immune therapy in lung cancer -- 3 Oncolytic virotherapy -- 3.1 DNA viruses -- 3.1.1 Adenoviruses -- 3.1.2 Poxviruses -- 3.1.3 Herpesvirus -- 3.1.4 Parvovirus -- 4 RNA viruses -- 4.1 Paramyxovirus -- 4.2 Rhabdovirus -- 4.3 Orthomyxovirus -- 4.4 Picornavirus -- 4.5 Reovirus -- 5 Discussion -- Acknowledgments -- References -- Chapter Eight: Rational selection of an ideal oncolytic virus to address current limitations in clinical translationRational selection of an ideal oncolytic virus to address current limitations in clinical translation -- 1 Introduction -- 2 Oncolytic virus landscape -- 2.1 Adenovirus -- 2.2 Herpes simplex virus -- 2.3 Vaccinia virus -- 2.4 Reovirus -- 2.5 Measles virus -- 3 Ideal properties of an oncolytic virus therapy -- 4 Vesicular stomatitis virus -- 4.1 Selectivity -- 4.2 Therapeutic transgenes -- 4.3 Genome stability -- 5 Conclusion -- Competing interests -- Acknowledgments -- References -- Backcover.
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|a Cancer
|x Immunotherapy
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