Different profiles of cytokine expression during mild and severe acute pancreatitis / Zilvinas Dambrauskas, Nathalia Giese, Antanas Gulbinas, Thomas Giese, Pascal O. Berberat, Juozas Pundzius, Giedrius Barauskas, Helmut Friess
AIM: To study secretion patterns of pro- and anti-inflammatory cytokines, and activation of various cellular subsets of leukocytes in peripheral blood. - METHODS: We have conducted a prospective observational study. One hundred and eight patients with a diagnosis of acute pancreatitis and onset of the disease within last 72 h were included in this study. The mRNA expression of 25 different types of cytokines in white blood cells was determined by quantitative real time polymerase chain reaction. Levels of 8 different cytokines in blood serum were measured by enzyme linked immunosorbent assay. Clinical data and cytokine expression results were subjected to statistical analysis. - RESULTS: Severe and necrotizing acute pancreatitis (AP) is characterized by the significant depletion of circulating lymphocytes. Severe acute pancreatitis is associated with a typical systemic inflammatory response syndrome and over-expression of pro-inflammatory cytokines [interleukin (IL)-6, IL-8, macrophage migration inhibitory factor (MIF)]. Serum IL-6 and MIF concentrations are the best discriminators of severe and necrotizing AP as well as possible fatal outcome during the early course of the disease. - CONCLUSION: Deregulation of cellular immune system is a key event leading to severe and necrotizing AP. IL-6 and MIF could be used as early predictors of complications..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
21 April 2010 2010 |
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| Erschienen: |
21 April 2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
World journal of gastroenterology - 16(2010), 15 vom: Apr., Seite 1845-1853 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dambrauskas, Zilvinas, 1976- [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Anmerkungen: |
Gesehen am 03.08.2023 |
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| Umfang: |
Illustrationen 9 |
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| doi: |
10.3748/wjg.v16.i15.1845 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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1854281968 |
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| 245 | 1 | 0 | |a Different profiles of cytokine expression during mild and severe acute pancreatitis |c Zilvinas Dambrauskas, Nathalia Giese, Antanas Gulbinas, Thomas Giese, Pascal O. Berberat, Juozas Pundzius, Giedrius Barauskas, Helmut Friess |
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| 520 | |a AIM: To study secretion patterns of pro- and anti-inflammatory cytokines, and activation of various cellular subsets of leukocytes in peripheral blood. - METHODS: We have conducted a prospective observational study. One hundred and eight patients with a diagnosis of acute pancreatitis and onset of the disease within last 72 h were included in this study. The mRNA expression of 25 different types of cytokines in white blood cells was determined by quantitative real time polymerase chain reaction. Levels of 8 different cytokines in blood serum were measured by enzyme linked immunosorbent assay. Clinical data and cytokine expression results were subjected to statistical analysis. - RESULTS: Severe and necrotizing acute pancreatitis (AP) is characterized by the significant depletion of circulating lymphocytes. Severe acute pancreatitis is associated with a typical systemic inflammatory response syndrome and over-expression of pro-inflammatory cytokines [interleukin (IL)-6, IL-8, macrophage migration inhibitory factor (MIF)]. Serum IL-6 and MIF concentrations are the best discriminators of severe and necrotizing AP as well as possible fatal outcome during the early course of the disease. - CONCLUSION: Deregulation of cellular immune system is a key event leading to severe and necrotizing AP. IL-6 and MIF could be used as early predictors of complications. | ||
| 650 | 4 | |a Acute pancreatitis | |
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Gene Expression Profiling | |
| 650 | 4 | |a Gene Expression Regulation | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Immune System | |
| 650 | 4 | |a Interleukin-6 | |
| 650 | 4 | |a Interleukin-8 | |
| 650 | 4 | |a Leukocytes | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Models, Biological | |
| 650 | 4 | |a Pancreatitis | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Prognostic factors | |
| 650 | 4 | |a Prospective Studies | |
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