Details der Publikation - Regional myocardial function in children with chronic aortic regurgitation

Regional myocardial function in children with chronic aortic regurgitation / Björn Goebel M.D., Tudor Poerner M.D., Matthias Gorenflo M.D., Alexander Lauten M.D., Christian Jung M.D., Jochen Grohmann M.D., Hans Figulla M.D., and Raoul Arnold M.D.

AIM: To determine the influence of volume overload on regional myocardial function in children with aortic regurgitation (AR) using tissue Doppler echocardiography and strain rate imaging (TDE/SRI). - METHODS: Thirty children with AR (median age 14 years (range 3-28 years)) were divided into three groups: mild (n = 6), moderate (n = 15), and severe AR (n = 9). Patients and 30 matched healthy controls underwent echocardiography with TDE/SRI. Cineloops were acquired from parasternal long- and short-axis and from apical four- and two-chamber views. The following parameters were extracted: peak systolic (V(S) ) and diastolic (V(E) ) velocities, peak systolic strain (S), peak systolic (SR(S) ), and early diastolic strain rate (SR(E) ). To quantify longitudinal LV function, V(S) and V(E) were obtained as peak values in the basal segments, whereas S, SR(S) , and SR(E) were expressed as mean values between basal and midwall segments. - RESULTS: Compared to the control group, patients showed a significant reduction in V(E) in the longitudinal direction (-91 ± 30 mm/sec for patients vs. 119 ± 20 mm/sec for control group). In patients with severe AR, longitudinal SR(E) was significantly reduced. On the other hand, we noted no differences between patients and controls with regard to S and SR(S) values. - CONCLUSION: Children with AR presented with significantly reduced longitudinal diastolic function (V(E) ). Severe AR leads to a decrease in diastolic myocardial deformation (SR(E) ). Due to the short duration of AR in this group of patients, systolic function (SR(S) ) is still preserved..

Medienart:	E-Artikel

Erscheinungsjahr:	21 June 2010 2010
Erschienen:	21 June 2010

Enthalten in:	Zur Gesamtaufnahme - volume:27
Enthalten in:	Echocardiography - 27(2010), 8, Seite 1021-1027

Sprache:	Englisch

Beteiligte Personen:	Goebel, Björn Carsten, 1976- [VerfasserIn] Poerner, Tudor [VerfasserIn] Gorenflo, Matthias [VerfasserIn] Lauten, Alexander, 1978- [VerfasserIn] Jung, Christian [VerfasserIn] Grohmann, Jochen [VerfasserIn] Figulla, Hans [VerfasserIn] Arnold, Raoul, 1967- [VerfasserIn]

Themen:	Adolescent Adult Aortic Valve Insufficiency Child, Preschool Chronic Disease Echocardiography, Doppler Elasticity Imaging Techniques Female Humans Male Reproducibility of Results Sensitivity and Specificity Stroke Volume Ventricular Dysfunction, Left Young Adult

Anmerkungen:	Gesehen am 06.04.2023

Umfang:	7

doi:	10.1111/j.1540-8175.2010.01195.x

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	184189222X

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245	1	0	\|a Regional myocardial function in children with chronic aortic regurgitation \|c Björn Goebel M.D., Tudor Poerner M.D., Matthias Gorenflo M.D., Alexander Lauten M.D., Christian Jung M.D., Jochen Grohmann M.D., Hans Figulla M.D., and Raoul Arnold M.D.
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520			\|a AIM: To determine the influence of volume overload on regional myocardial function in children with aortic regurgitation (AR) using tissue Doppler echocardiography and strain rate imaging (TDE/SRI). - METHODS: Thirty children with AR (median age 14 years (range 3-28 years)) were divided into three groups: mild (n = 6), moderate (n = 15), and severe AR (n = 9). Patients and 30 matched healthy controls underwent echocardiography with TDE/SRI. Cineloops were acquired from parasternal long- and short-axis and from apical four- and two-chamber views. The following parameters were extracted: peak systolic (V(S) ) and diastolic (V(E) ) velocities, peak systolic strain (S), peak systolic (SR(S) ), and early diastolic strain rate (SR(E) ). To quantify longitudinal LV function, V(S) and V(E) were obtained as peak values in the basal segments, whereas S, SR(S) , and SR(E) were expressed as mean values between basal and midwall segments. - RESULTS: Compared to the control group, patients showed a significant reduction in V(E) in the longitudinal direction (-91 ± 30 mm/sec for patients vs. 119 ± 20 mm/sec for control group). In patients with severe AR, longitudinal SR(E) was significantly reduced. On the other hand, we noted no differences between patients and controls with regard to S and SR(S) values. - CONCLUSION: Children with AR presented with significantly reduced longitudinal diastolic function (V(E) ). Severe AR leads to a decrease in diastolic myocardial deformation (SR(E) ). Due to the short duration of AR in this group of patients, systolic function (SR(S) ) is still preserved.
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650		4	\|a Aortic Valve Insufficiency
650		4	\|a Child, Preschool
650		4	\|a Chronic Disease
650		4	\|a Echocardiography, Doppler
650		4	\|a Elasticity Imaging Techniques
650		4	\|a Female
650		4	\|a Humans
650		4	\|a Male
650		4	\|a Reproducibility of Results
650		4	\|a Sensitivity and Specificity
650		4	\|a Stroke Volume
650		4	\|a Ventricular Dysfunction, Left
650		4	\|a Young Adult
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700	1		\|a Jung, Christian \|e verfasserin \|4 aut
700	1		\|a Grohmann, Jochen \|e verfasserin \|4 aut
700	1		\|a Figulla, Hans \|e verfasserin \|4 aut
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Regional myocardial function in children with chronic aortic regurgitation / Björn Goebel M.D., Tudor Poerner M.D., Matthias Gorenflo M.D., Alexander Lauten M.D., Christian Jung M.D., Jochen Grohmann M.D., Hans Figulla M.D., and Raoul Arnold M.D.

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