Details der Publikation - Differentiation-induced rearrangement of the mitochondrial calcium uniporter complex regulates t-cell-mediated immunity

Differentiation-induced rearrangement of the mitochondrial calcium uniporter complex regulates t-cell-mediated immunity / submitted by Magdalena Shumanska ; First reviewer: Prof. Dr. Ivan Bogeski, Second Reviewer: Prof. Dr. mult. Thomas Meyer

CD4+ T-cells are an important cell type involved in proper mediation of the human adaptive immune system. Activation of CD4+ T-cells is a regulated process which includes a tightly controlled cytosolic calcium (Ca2+) increase. Multiple fundamental T-cell processes are governed by Ca2+ ions, including cell subtype differentiation, energy production, proliferation, migration, and effector molecule secretion. Mitochondria are the main Ca2+ buffering system in T-cells, allowing proper regulation and support of cellular metabolic demands. The mitochondrial calcium uniporter (MCU) complex is the ....

Medienart:	E-Book

Erscheinungsjahr:	2023
Erschienen:	Göttingen: 2023

Weitere Ausgaben:	Erscheint auch als Druck-Ausgabe: Differentiation-induced rearrangement of the mitochondrial calcium uniporter complex regulates t-cell-mediated immunity

Sprache:	Englisch

Beteiligte Personen:	Shumanska, Magdalena [VerfasserIn] Bogeski, Ivan [Akademische/r BetreuerIn] Meyer, Thomas [Akademische/r BetreuerIn]
Hochschulschrift:	Dissertation, Georg-August-Universität Göttingen, 2022

Links:	Volltext [kostenfrei] Volltext [kostenfrei] d-nb.info [kostenfrei]

Themen:	Autoimmunity Calcium Hochschulschrift Metabolism Mitochondria T-cells

Umfang:	1 Online-Ressource ; Illustrationen, Diagramme

Weitere IDs:	urn:nbn:de:gbv:7-ediss-14468-6

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1831754940

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Differentiation-induced rearrangement of the mitochondrial calcium uniporter complex regulates t-cell-mediated immunity / submitted by Magdalena Shumanska ; First reviewer: Prof. Dr. Ivan Bogeski, Second Reviewer: Prof. Dr. mult. Thomas Meyer

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