Reevaluation der potenziell onkogenen, Lymphom-assoziierten Missense-Mutation D427H im STAT3-Molekül / vorgelegt von Lena Sophie Behrendsen ; Betreuer/in: Prof. Dr. med. Dr. phi. Dr. rer. nat. T. Meyer, Kobetreuer/in: Prof. Dr. rer. nat. S. Lutz
The transcription factor STAT3 (signal transducer and activator of transcription 3) promotes cell proliferation, immunomodulation, and maintenance of a stem cell state, such that its constitutive activation in cells carries oncogenic potential. Numerous point mutations in the STAT3 protein have been described, conferring increased oncogenic properties to the molecule and have been associated with various tumors. Among them is the missense mutation D427H localized in the DNA-binding domain of the STAT3 molecule, which was discovered in association with NK/T-cell lymphomas. However, character....
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
Göttingen: 2023 |
| Weitere Ausgaben: |
Erscheint auch als Druck-Ausgabe: Reevaluation der potenziell onkogenen, Lymphom-assoziierten Missense-Mutation D427H im STAT3-Molekül |
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| Sprache: |
Deutsch |
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| Beteiligte Personen: |
Behrendsen, Lena Sophie, 1998- [VerfasserIn] |
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| Hochschulschrift: |
| Links: |
Volltext [kostenfrei] |
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| Themen: |
DNA binding |
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| Umfang: |
1 Online-Ressource ; Illustrationen, Diagramme |
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| Weitere IDs: |
urn:nbn:de:gbv:7-ediss-14441-6 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
1830533142 |
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| 245 | 1 | 0 | |a Reevaluation der potenziell onkogenen, Lymphom-assoziierten Missense-Mutation D427H im STAT3-Molekül |c vorgelegt von Lena Sophie Behrendsen ; Betreuer/in: Prof. Dr. med. Dr. phi. Dr. rer. nat. T. Meyer, Kobetreuer/in: Prof. Dr. rer. nat. S. Lutz |
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| 520 | |a The transcription factor STAT3 (signal transducer and activator of transcription 3) promotes cell proliferation, immunomodulation, and maintenance of a stem cell state, such that its constitutive activation in cells carries oncogenic potential. Numerous point mutations in the STAT3 protein have been described, conferring increased oncogenic properties to the molecule and have been associated with various tumors. Among them is the missense mutation D427H localized in the DNA-binding domain of the STAT3 molecule, which was discovered in association with NK/T-cell lymphomas. However, character... | ||
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