Interferon-γ-inducing factor (IL-18) and interferon-γ in inflammatory CNS diseases / K. Fassbender, O. Mielke, T. Bertsch, F. Muehlhauser, M. Hennerici, M. Kurimoto, and S. Rossol
OBJECTIVE: To examine the intrathecal production of a newly identified cytokine, interferon-gamma-inducing factor (IL-18), together with interferon-gamma itself, in inflammatory diseases of the CNS (i.e., bacterial meningitis, viral meningoencephalitis, and MS). - RESULTS: IL-18 concentrations in CSF were significantly increased in bacterial meningitis and tended toward increased levels in viral meningoencephalitis. In contrast, IL-18 was detectable only in a few patients with MS and healthy controls. Interestingly, interferon-gamma was significantly increased selectively in CSF of patients with viral meningoencephalitis. - CONCLUSION: The observation of an intrathecal release of IL-18 in patients with meningitis argues for a pathophysiologic role of this novel cytokine in immunity against invading microorganisms the CNS..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
September 1, 1999 1999 |
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| Erschienen: |
September 1, 1999 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Neurology - 53(1999), 5, Seite 1104-1106 |
| Sprache: |
Englisch |
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| Weiterer Titel: |
Interferon-gamma-inducing factor (IL-18) and interferon-gamma in inflammatory CNS diseases |
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| Beteiligte Personen: |
Faßbender, Klaus [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Adult |
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| Anmerkungen: |
Gesehen am 27.07.2022 |
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| Umfang: |
3 |
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| doi: |
10.1212/wnl.53.5.1104 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Interferon-γ-inducing factor (IL-18) and interferon-γ in inflammatory CNS diseases |c K. Fassbender, O. Mielke, T. Bertsch, F. Muehlhauser, M. Hennerici, M. Kurimoto, and S. Rossol |
| 246 | 3 | 3 | |a Interferon-gamma-inducing factor (IL-18) and interferon-gamma in inflammatory CNS diseases |
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| 520 | |a OBJECTIVE: To examine the intrathecal production of a newly identified cytokine, interferon-gamma-inducing factor (IL-18), together with interferon-gamma itself, in inflammatory diseases of the CNS (i.e., bacterial meningitis, viral meningoencephalitis, and MS). - RESULTS: IL-18 concentrations in CSF were significantly increased in bacterial meningitis and tended toward increased levels in viral meningoencephalitis. In contrast, IL-18 was detectable only in a few patients with MS and healthy controls. Interestingly, interferon-gamma was significantly increased selectively in CSF of patients with viral meningoencephalitis. - CONCLUSION: The observation of an intrathecal release of IL-18 in patients with meningitis argues for a pathophysiologic role of this novel cytokine in immunity against invading microorganisms the CNS. | ||
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