Pertussis : Epidemiology, Immunology, and Evolution

Pertussis, or whooping cough, is a respiratory disease caused primarily by infection with the bacterium Bordetella pertussis and remains the leading cause of death amongst vaccine-preventable diseases worldwide. This volume aims to synthesize the current understanding of this critically important, global pathogen..

Cover -- Pertussis: Epidemiology, Immunology, and Evolution -- Copyright -- Dedication -- Foreword -- Acknowledgements -- Contents -- List of Contributors -- Prologue: the pertussis problem -- History: origins, vaccines, and health burden -- 1950s onwards: declining incidence, candidate for eradication -- Resurgence despite high vaccine uptake: highest burden of any vaccine-preventable disease -- Pertussis today -- References -- CHAPTER 1: Introduction to pertussis transmission and epidemiological dynamics -- Abstract -- 1.1 Introduction -- 1.2 Transmission models -- 1.3 Disease prevalence -- 1.3.1 Relationship with changing vaccines -- 1.3.2 Relationship with immune waning -- 1.4 Under-reporting -- 1.4.1 Relationship with sources of infection -- 1.5 Periodicity -- 1.6 Extinction profile -- 1.7 Age structure -- 1.8 Seasonality -- 1.9 Spatial dynamics -- 1.10 Phylodynamics -- 1.11 Summary -- References -- CHAPTER 2: Basics of pertussis pathogenesis -- Abstract -- 2.1 Introduction -- 2.2 Animal-based experimental studies of pathogenesis -- 2.2.1 Baboon model -- 2.2.2 Mouse model -- 2.2.3 Other Bordetella species in the mouse model -- 2.3 Virulence factors and pathogenesis -- 2.3.1 Toxins -- Pertussis toxin -- Adenylate cyclase toxin -- Dermonecrotic toxin -- Tracheal cytotoxin -- 2.3.2 Adhesins -- Filamentous haemagglutinin -- Fimbriae -- 2.3.3 Autotransporters -- Pertactin -- Bordetella resistance to killing protein -- Vir-activated gene 8 -- Tracheal colonization factor -- SphB1 -- 2.3.4 Bordetella polysaccharide -- 2.3.5 Host factor-bacteriophage Qβ -- 2.3.6 Type III secretion system -- 2.3.7 Type VI secretion system -- 2.3.8 Lipooligosaccharides -- 2.4 Microbiota -- 2.5 Conclusion -- References -- CHAPTER 3: The immunology of Bordetella pertussis infection and vaccination -- Abstract -- 3.1 Introduction -- 3.2 Innate immunity..

Medienart:	E-Book

Erscheinungsjahr:	2019 ©2019
Erschienen:	Oxford: Oxford University Press USA - OSO ; 2019 ©2019

Reihe:	Ecology and Evolution of Infectious Diseases Ser.

Sprache:	Englisch

Beteiligte Personen:	Rohani, Pejman [VerfasserIn] Scarpino, Samuel [Mitwirkende/r]

Links:	ebookcentral.proquest.com [lizenzpflichtig]

ISBN:	978-0-19-253986-1

Themen:	Electronic books Whooping cough Whooping cough-Epidemiology

Anmerkungen:	Description based on publisher supplied metadata and other sources

Umfang:	1 online resource (289 pages)

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1809570360