Biphasic effects of blue light irradiation on human umbilical vein endothelial cells / Kejia Kan, Yifei Mu, Marielle Bouschbacher, Carsten Sticht, Natalia Kuch, Martin Sigl, Nuh Rahbari, Norbert Gretz, Prama Pallavi and Michael Keese
Blue light regulates biological function in various cells, such as proliferation, oxidative stress, and cell death. We employed blue light illumination on human umbilical vein endothelial cells utilizing a LED device at 453 nm wavelength and revealed a novel biphasic response on human umbilical vein endothelial cells (HUVECs). The results showed that low fluence blue light irradiation promoted the fundamental cell activities, including cell viability, migration and angiogenesis by activating the angiogenic pathways such as the VEGF signaling pathway. In contrast, high fluence illumination caused the opposite effect on those activities by upregulating pro-apoptotic signaling cascades like ferroptosis, necroptosis and the p53 signaling pathways. Our results provide an underlying insight into photobiomodulation by blue light and may help to implement potential treatment strategies for treating angiogenesis-dependent diseases..
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
16 July 2021 2021 |
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Erschienen: |
16 July 2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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Enthalten in: |
Biomedicines - 9(2021), 7 vom: Juli, Artikel-ID 829, Seite 1-16 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Kan, Kejia, 1990- [VerfasserIn] |
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Links: |
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Themen: |
Angiogenesis |
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Anmerkungen: |
Published: 16 July 2021 Gesehen am 24.06.2022 |
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Umfang: |
16 |
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doi: |
10.3390/biomedicines9070829 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
1807749886 |
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