Design of Experiments for Pharmaceutical Product Development : Volume II : Applications and Practical Case Studies

Intro -- Contents -- About the Editor -- 1: Introduction to the Application of Experimental Designs in Pharmaceutical Product Development -- 1.1 Introduction -- 1.2 Early History and Evolution of Experimental Designs -- 1.3 Experimental Design Principles -- 1.3.1 Replication -- 1.3.2 Randomization -- 1.3.3 Blocking or Error Control -- 1.4 General Considerations in Performing DoE -- 1.4.1 Defining the Problem -- 1.4.2 Establishment of Cause-and-Effect Relationship -- 1.4.3 Selection of Critical Factors by Screening -- 1.4.4 Selection of the Critical Response Variable(s) -- 1.4.5 Experimental Design-Based Factor Optimization -- 1.4.6 Selection of Optimum Solution and Model Validation -- 1.5 Experimental Design Selection and Types -- 1.5.1 Screening Designs -- 1.5.1.1 Fractional Factorial Design -- 1.5.1.2 Taguchi Design -- 1.5.1.3 Plackett-Burman Design -- 1.5.2 Response Surface Designs -- 1.5.2.1 Full Factorial Design -- 1.5.2.2 Central Composite Design -- 1.5.2.3 Box-Behnken Design -- 1.5.2.4 Optimal Designs -- 1.5.2.5 Mixture Designs -- 1.6 Applications of DoE in Drug Product Development -- 1.6.1 Oral Drug Delivery Systems -- 1.6.2 Non-oral Drug Delivery Systems -- 1.7 Conclusion and Future Perspectives -- References -- 2: Design of Experiments for the Development of Solid Oral Dosage Forms -- 2.1 Introduction -- 2.2 DoE Application for Developing the Solid Dosage Forms -- 2.2.1 In the Development of Tablet Dosage Forms -- 2.2.2 In the Development of Capsule Dosage Form -- 2.2.3 In the Tablet Coating Process -- 2.2.4 In the Pharmaceutical Pellets Manufacturing -- 2.3 Conclusion and Future Directions -- References -- 3: Design of Experiments for the Development of Topical Drug Products -- 3.1 Introduction -- 3.2 Advantages of Topical Drug Delivery -- 3.3 Challenges in Topical Delivery -- 3.4 Role of Nanocarriers in Topical Delivery..

Medienart:	E-Book

Erscheinungsjahr:	2021 ©2021
Erschienen:	Singapore: Springer Singapore Pte. Limited ; 2021 ©2021

Sprache:	Englisch

Beteiligte Personen:	Beg, Sarwar [HerausgeberIn]

Links:	ebookcentral.proquest.com [lizenzpflichtig]

ISBN:	978-981-334-351-1

BKL:	44.40 / Pharmazie / Pharmazeutika
Themen:	Arzneimittelentwicklung Drug development Electronic books

Anmerkungen:	Description based on publisher supplied metadata and other sources

Umfang:	1 Online-Ressource (190 Seiten)

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	178888504X