The olfactory abilities of canines - detection of the novel coronavirus SARS-CoV-2 in human body fluids by detection dogs / vorgelegt von Paula Jendrny
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
Hannover: Tierärztliche Hochschule Hannover ; 2021 |
| Weitere Ausgaben: |
Erscheint auch als Druck-Ausgabe: The olfactory abilities of canines - detection of the novel coronavirus SARS-CoV-2 in human body fluids by detection dogs |
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| Sprache: |
Englisch Zusammenfassungen in deutscher und englischer Sprache |
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| Weiterer Titel: |
Übersetzung: Die olfaktorischen Fähigkeiten des Hundes – Detektion des neuartigen Coronavirus SARS-CoV-2 in humanen Körperflüssigkeiten durch Spürhunde |
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| Beteiligte Personen: |
Jendrny, Paula [VerfasserIn] |
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| Hochschulschrift: |
| Links: |
Volltext |
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| Themen: |
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| Umfang: |
1 Online-Ressource (103 Seiten) |
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| Weitere IDs: |
urn:nbn:de:gbv:95-116642 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
1785325035 |
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| 245 | 1 | 4 | |a The olfactory abilities of canines - detection of the novel coronavirus SARS-CoV-2 in human body fluids by detection dogs |c vorgelegt von Paula Jendrny |
| 246 | 1 | |i Übersetzung |a Die olfaktorischen Fähigkeiten des Hundes – Detektion des neuartigen Coronavirus SARS-CoV-2 in humanen Körperflüssigkeiten durch Spürhunde | |
| 264 | 1 | |a Hannover |b Tierärztliche Hochschule Hannover |c 2021 | |
| 300 | |a 1 Online-Ressource (103 Seiten) | ||
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| 508 | |a The overall objectives of this thesis were to reveal evidence of a global, severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)-specific odour in sample material from infected individuals that trained dogs can be able to detect with high diagnostic accuracies, as well as the development of an effective and safe training method for SARS-CoV-2 detection dogs. In both parts of the project, German Armed Forces service dogs were conditioned to a SARS-CoV-2 specific scent with a device called Detection Dog Training System (DDTS; Kynoscience UG, Germany) based on positive reinforcement to avoid any bias by dog handler or trainer and promote independent work of the dogs. In the initial pilot study, we were able to address the question of an existing pathogen-specific odour in beta propiolactone (BPL)-inactivated salivary and tracheobronchial secretion samples from hospitalised coronavirus disease 2019 (COVID-19) patients and achieved high diagnostic accuracies in dogs with little variance in specificity but relatively high variance in sensitivity. For this purpose, ten service dogs of the German Armed Forces were trained but only eight were suitable for the test procedure. The dogs were capable of discriminating between samples of SARS-CoV-2 infected and non-infected individuals with average diagnostic sensitivity of 83% and specificity of 96%. During the presentation of 1012 randomised samples, the dogs achieved an overall average detection rate of 94% (±3.4%). These findings indicate that trained detection dogs are able to detect respiratory secretion samples from hospitalised and clinically diseased SARS-CoV-2 infected patients by discriminating between samples from SARS-CoV-2 infected patients and negative controls. In the second study, ten dogs were trained for eight days to detect SARS-CoV-2 infections in beta-propiolactone inactivated saliva samples as used in the pilot study. Thereafter, the subsequent cognitive transfer performance for the recognition of non-inactivated sample material and diagnostic accuracy were tested on non-inactivated saliva, urine, and sweat samples in a randomised, double-blinded controlled study. Dogs trained to detect inactivated saliva samples from SARS-CoV-2 infected patients transferred the conditioned odour to non-inactivated saliva samples without further training. They were tested on a total of 5242 randomised samples and identified non-inactivated saliva samples with a sensitivity of 84% and specificity of 95%. In a following experiment to compare the odour detection between the three non-inactivated body fluids, diagnostic sensitivity and specificity were 95% and 98% for urine, 91% and 94% for sweat, 82%, and 96% for saliva, respectively. These findings indicate a general symptom- and body fluid-independent, SARS-CoV-2-specific VOC-pattern detectable by trained dogs. All of the three body fluids were equally suitable for this screening method. Overall, it was demonstrated that it is possible to condition dogs to a general SARS-CoV-2 specific odour in different body fluids (saliva, urine, sweat) and to train a reliable indication behaviour. The developed training method is effective, successful and leads to a high diagnostic accuracy. The importance of medical detection dogs shows an upward trend, however, some difficulties must be overcome in standardised dog training and certification of the method in order to train reliable detection dogs. | ||
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