Treatment and outcome of patients with metastatic NSCLC : a retrospective institution analysis of 493 patients / Niels Reinmuth, Nadine Payer, Thomas Muley, Hans Hoffmann, Felix Jf Herth, Matthias Villalobos and Michael Thomas

BACKGROUND: Most patients with metastatic non-small cell lung cancer (NSCLC) will face treatment with systemic therapy. Current clinical studies are demonstrating improvements in chemotherapy and overall survival. However, it remains unclear whether these results are translated into clinical practice. - METHODS: We reviewed all stage IV NSCLC patients without second malignancies that were diagnosed from 2004 to 2006 at our institution. 493 consecutive patients were included into this retrospective analysis and were followed-up until end of 2011. - RESULTS: 352 patients (71.4%) received systemic therapy for up to 7 lines. For most patients, adjustments of dosages or applications had to be made at some point of the treatment, but the total applied dose remained generally close to the intended dose. The best disease control (BDC) rate decreased with increasing therapy lines from 59.7% to about 35%. Patients with palliative local therapy but no systemic treatment demonstrated inferior survival (median 2.9 versus 8.7 months, p < 0.001). The median interval between last treatment and death was 50 days and 15 days for chemotherapy and anti-EGFR therapy, respectively. BDC to the previous therapy lines was predictive for improved BDC to third- but not second-line therapy. Performing multivariate analysis, BDC to previous therapy, never-/ former-smoking status, and age > 70 years were associated with improved survival performing third-line therapy. - CONCLUSIONS: Stage IV NSCLC patients may receive substantial systemic therapy resulting in response and median survival rates that are comparable to data from clinical studies. However, preselection factors are increasingly important to improve therapy outcome and life quality..

Medienart:

E-Artikel

Erscheinungsjahr:

18 December 2013

2013

Erschienen:

18 December 2013

Enthalten in:

Zur Gesamtaufnahme - volume:14

Enthalten in:

Respiratory research - 14(2013), Artikel-ID 139, Seite 1-9

Sprache:

Englisch

Beteiligte Personen:

Reinmuth, Niels, 1970- [VerfasserIn]
Payer, Nadine, 1983- [VerfasserIn]
Muley, Thomas [VerfasserIn]
Hoffmann, Hans, 1957- [VerfasserIn]
Herth, Felix [VerfasserIn]
Villalobos Bollen, Matthias Americo, 1974- [VerfasserIn]
Thomas, Michael [VerfasserIn]

Links:

Volltext [lizenzpflichtig]
Volltext [lizenzpflichtig]

Themen:

Adult
Aged
Aged, 80 and over
Antineoplastic Agents
Carcinoma, Non-Small-Cell Lung
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Humans
Lung Neoplasms
Male
Middle Aged
Multivariate Analysis
Neoplasm Metastasis
Neoplasm Staging
Prognosis
Retrospective Studies
Survival Rate
Treatment Outcome

Anmerkungen:

Gesehen am 07.01.2022

DOI funktioniert nicht

Umfang:

9

doi:

10.1186/1465-9921-14-139

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

1785194801

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