Personalised Health Care : Fostering Precision Medicine Advancements for Gaining Population Health Impact
Intro -- Acknowledgements -- List of Abbreviations -- Contents -- About the Editors -- Contributors -- Chapter 1: Introductions -- References -- Chapter 2: Identification of Biomarkers for the Prevention of Chronic Disease -- 2.1 Identification of Novel Biomarkers for Primary and Secondary Prevention of Diabetes in the -Omics Era -- Genomics -- Transcriptomics -- Epigenomics -- Metabolomics -- Conclusions -- 2.2 The Prognostic Role of Micro-RNAs in Head and Neck Cancers: An Umbrella Review -- Methods -- Results -- Discussion and Conclusion -- 2.3 Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Non-communicable Diseases -- Risk for the Development of Thrombosis -- Risk for the Development of Hypertension -- Risk for the Development of Type 2 Diabetes Mellitus -- Risk for the Development of Atherosclerosis (Reduced HDL-C Level) -- 2.4 Polygenic Risk Score for Data-Driven Health Care in the Big Data Age -- The UK Biobank -- Polygenic Risk Score -- New Challenges in Preventive Medicine -- Market Needs -- References -- Chapter 3: Evaluation of Predictive Genomic Applications -- 3.1 The Health Technology Assessment Approach for the Evaluation of Genetic/Genomic Applications -- Introduction -- The ACCE Model -- The HTA Model -- The Need of a More Comprehensive Evaluation Framework? -- 3.2 The Economic Evaluation of Genomic Applications -- Economic Evaluation in Healthcare -- Cost-Effectiveness Analysis and Health Programmes Involving Genomic Applications -- The Dual Purpose of Cost-Effectiveness Analysis in Genomics -- When Do We Perform a Cost-Effectiveness Analysis? -- Case Studies of Cost-Effective Genomic Health Programmes Ready to be Implemented in Clinical and Public Health Practice -- Genomic Health Programmes for BRCA-Related Cancers..
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E-Book |
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| Erscheinungsjahr: |
2020 ©2021 |
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| Erschienen: |
Cham: Springer International Publishing AG ; 2020 ©2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Boccia, Stefania [VerfasserIn] |
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| Links: |
ebookcentral.proquest.com [lizenzpflichtig] |
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| ISBN: |
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| Anmerkungen: |
Description based on publisher supplied metadata and other sources |
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| Umfang: |
1 online resource (135 pages) |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
1782442251 |
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| 520 | |a Intro -- Acknowledgements -- List of Abbreviations -- Contents -- About the Editors -- Contributors -- Chapter 1: Introductions -- References -- Chapter 2: Identification of Biomarkers for the Prevention of Chronic Disease -- 2.1 Identification of Novel Biomarkers for Primary and Secondary Prevention of Diabetes in the -Omics Era -- Genomics -- Transcriptomics -- Epigenomics -- Metabolomics -- Conclusions -- 2.2 The Prognostic Role of Micro-RNAs in Head and Neck Cancers: An Umbrella Review -- Methods -- Results -- Discussion and Conclusion -- 2.3 Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Non-communicable Diseases -- Risk for the Development of Thrombosis -- Risk for the Development of Hypertension -- Risk for the Development of Type 2 Diabetes Mellitus -- Risk for the Development of Atherosclerosis (Reduced HDL-C Level) -- 2.4 Polygenic Risk Score for Data-Driven Health Care in the Big Data Age -- The UK Biobank -- Polygenic Risk Score -- New Challenges in Preventive Medicine -- Market Needs -- References -- Chapter 3: Evaluation of Predictive Genomic Applications -- 3.1 The Health Technology Assessment Approach for the Evaluation of Genetic/Genomic Applications -- Introduction -- The ACCE Model -- The HTA Model -- The Need of a More Comprehensive Evaluation Framework? -- 3.2 The Economic Evaluation of Genomic Applications -- Economic Evaluation in Healthcare -- Cost-Effectiveness Analysis and Health Programmes Involving Genomic Applications -- The Dual Purpose of Cost-Effectiveness Analysis in Genomics -- When Do We Perform a Cost-Effectiveness Analysis? -- Case Studies of Cost-Effective Genomic Health Programmes Ready to be Implemented in Clinical and Public Health Practice -- Genomic Health Programmes for BRCA-Related Cancers. | ||
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