The use of antivirals for influenza prophylaxis : a review of the clinical effectiveness / authors, Yi-Sheng Chao, Carolyn Spry
Influenza is seasonal and usually caused by the influenza A or B virus. It is a major disease burden leading to more than 5% of adults and 20% of children being infected annually. Pandemic influenza can occur while a new strain of virus becomes the cause of infection, such as influenza 2009A/H1N1. Vaccination can be effective in controlling influenza transmission. However, there are several factors that influence the effectiveness of vaccinations, including improper matching between vaccine and virus strains, antigenic drifts and inadequate vaccine coverage. In addition to vaccination, antivirals are used orally or through other routes at an earlier stage to prevent infection and transmission of the influenza. Antivirals inhibit virus replication, and the decrease in virus shedding within infected individuals may be the reason of reduced transmission. Unlike vaccination, antivirals need to be stockpiled for influenza prevention or treatment. The cost of storage and the uncertainty in the effectiveness warrant further review of the effectiveness of antivirals on influenza prophylaxis. This review aims to update the 2010 Rapid Response report by summarizing the recent literature on the effectiveness of antivirals on influenza prophylaxis..
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
July 05, 2017 |
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| Erschienen: |
Ottawa (ON): CADTH ; July 05, 2017 |
| Ausgabe: |
Version: 1.0. |
| Reihe: |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chao, Yi-Sheng [VerfasserIn] |
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| Links: |
www.ncbi.nlm.nih.gov [teilw. kostenfrei] |
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| Themen: |
Antiviral Agents |
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| Anmerkungen: |
Includes bibliographical references. - Description based on online resource; title from PDF title page (viewed January 14, 2019) |
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| Umfang: |
1 online resource (1 PDF file (31 pages)). |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
1773199412 |
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| 245 | 1 | 4 | |a The use of antivirals for influenza prophylaxis |b a review of the clinical effectiveness |c authors, Yi-Sheng Chao, Carolyn Spry |
| 250 | |a Version: 1.0. | ||
| 264 | 1 | |a Ottawa (ON) |b CADTH |c July 05, 2017 | |
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| 490 | 0 | |a Rapid response report: summary with critical appraisal | |
| 500 | |a Includes bibliographical references. - Description based on online resource; title from PDF title page (viewed January 14, 2019) | ||
| 520 | |a Influenza is seasonal and usually caused by the influenza A or B virus. It is a major disease burden leading to more than 5% of adults and 20% of children being infected annually. Pandemic influenza can occur while a new strain of virus becomes the cause of infection, such as influenza 2009A/H1N1. Vaccination can be effective in controlling influenza transmission. However, there are several factors that influence the effectiveness of vaccinations, including improper matching between vaccine and virus strains, antigenic drifts and inadequate vaccine coverage. In addition to vaccination, antivirals are used orally or through other routes at an earlier stage to prevent infection and transmission of the influenza. Antivirals inhibit virus replication, and the decrease in virus shedding within infected individuals may be the reason of reduced transmission. Unlike vaccination, antivirals need to be stockpiled for influenza prevention or treatment. The cost of storage and the uncertainty in the effectiveness warrant further review of the effectiveness of antivirals on influenza prophylaxis. This review aims to update the 2010 Rapid Response report by summarizing the recent literature on the effectiveness of antivirals on influenza prophylaxis. | ||
| 650 | 2 | |a Influenza, Human |x prevention & control |0 https://id.nlm.nih.gov/mesh/D007251Q000517 | |
| 650 | 2 | |a Influenza, Human |x immunology |0 https://id.nlm.nih.gov/mesh/D007251Q000276 | |
| 650 | 2 | |a Influenza Vaccines |x therapeutic use |0 https://id.nlm.nih.gov/mesh/D007252Q000627 | |
| 650 | 2 | |a Antiviral Agents |x therapeutic use |0 https://id.nlm.nih.gov/mesh/D000998Q000627 | |
| 650 | 2 | |a Treatment Outcome |0 https://id.nlm.nih.gov/mesh/D016896 | |
| 650 | 2 | |a Comparative Effectiveness Research |0 https://id.nlm.nih.gov/mesh/D057186 | |
| 655 | 2 | |a Review |0 https://id.nlm.nih.gov/mesh/D016454 | |
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