Host-pneumococcal interactions - from the lung to the brain / vorgelegt von Jolien Seinen ; 1. Gutachter: Prof. Dr. Sven Hammerschmidt, 2. Gutachter: Prof. Dr. Jan Maarten van Dijl, 3. Gutachter: Prof. Dr. Peter F. Zipfel
Infektionen, Lunge, Molekularbiologie, Sputum, Streptococcus pneumoniae.
Mechanically ventilated patients are at risk of ventilator-associated pneumonia, a serious infection of the lungs. Not every ventilated patient develops pneumonia due to a combination of the protective layer of mucus in the airways, the immune system and prophylactic antibiotic therapy. To date, only little was known about the antimicrobial factors produced by humans that protect the lungs against infection. Research described in this thesis was therefore aimed at investigating to what extent the lungs of ventilated patients can inhibit the growth of bacteria, the major causative agent of pneumonia Streptococcus pneumoniae in particular. To this end, the accumulated mucus in the patients’ lungs, sputum, was investigated. The most important conclusion was that sputum can indeed possess antimicrobial activity, explained either by a combination of antibiotics and S. pneumoniae-specific antibodies, or by the innate immune defenses. Thus, sputum may serve as a valuable source of information to unravel the complex interactions between the human host, antimicrobial factors and the microbiome of the lower respiratory tract. A possible consequence of pneumonia is the dissemination of bacteria from the lungs to the bloodstream and the brain, which may lead to meningitis. This thesis describes how this process takes place, and how the so-called choline-binding protein CbpL contributes to invasive pneumococcal infections. In addition, possible future approaches to prevent meningitis ....
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
10.07.2020 |
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| Erschienen: |
Greifswald: 10.07.2020 |
| Weitere Ausgaben: |
Erscheint auch als Druck-Ausgabe: Host-pneumococcal interactions - from the lung to the brain |
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| Sprache: |
Englisch ; Deutsch ; Niederländisch Zusammenfassung in deutscher Sprache |
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| Beteiligte Personen: |
Seinen, Jolien, 1989- [VerfasserIn] |
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| Hochschulschrift: |
Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2020 |
| Links: |
Volltext [kostenfrei] |
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| BKL: | |
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| Themen: |
Gehirn |
| Anmerkungen: |
Literaturangaben |
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| Umfang: |
1 Online-Ressource (PDF-Datei: 131 Seiten, 24848 Kilobyte) ; Illustrationen (farbig), Diagramme (teilweise farbig) |
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| Weitere IDs: |
urn:nbn:de:gbv:9-opus-44590 |
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| Förderinstitution / Projekttitel: |
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1753361923 |
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| 245 | 1 | 0 | |a Host-pneumococcal interactions - from the lung to the brain |c vorgelegt von Jolien Seinen ; 1. Gutachter: Prof. Dr. Sven Hammerschmidt, 2. Gutachter: Prof. Dr. Jan Maarten van Dijl, 3. Gutachter: Prof. Dr. Peter F. Zipfel |
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| 520 | |a Mechanically ventilated patients are at risk of ventilator-associated pneumonia, a serious infection of the lungs. Not every ventilated patient develops pneumonia due to a combination of the protective layer of mucus in the airways, the immune system and prophylactic antibiotic therapy. To date, only little was known about the antimicrobial factors produced by humans that protect the lungs against infection. Research described in this thesis was therefore aimed at investigating to what extent the lungs of ventilated patients can inhibit the growth of bacteria, the major causative agent of pneumonia Streptococcus pneumoniae in particular. To this end, the accumulated mucus in the patients’ lungs, sputum, was investigated. The most important conclusion was that sputum can indeed possess antimicrobial activity, explained either by a combination of antibiotics and S. pneumoniae-specific antibodies, or by the innate immune defenses. Thus, sputum may serve as a valuable source of information to unravel the complex interactions between the human host, antimicrobial factors and the microbiome of the lower respiratory tract. A possible consequence of pneumonia is the dissemination of bacteria from the lungs to the bloodstream and the brain, which may lead to meningitis. This thesis describes how this process takes place, and how the so-called choline-binding protein CbpL contributes to invasive pneumococcal infections. In addition, possible future approaches to prevent meningitis ... | ||
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