Details der Publikation - Detecting legionellosis by unselected culture of respiratory tract secretions and developing links to hospital water strains

Detecting legionellosis by unselected culture of respiratory tract secretions and developing links to hospital water strains / J.R. Köhler, M. Maiwald, P.C. Lück, J.H. Helbig, V. Hingst, H.G. Sonntag

For a 13-month period, all respiratory tract secretions submitted for routine bacteriology from a large hospital complex were cultured for legionella, irrespective of clinical diagnosis and laboratory requests. Ten cases of legionellosis were detected in this manner, three of which met a strict epidemiological definition of hospital-acquired. Therefore, the 16 warm-water systems of the hospitals, spread out over two locations, were examined for the presence of legionella. Legionella pneumophila was found in 15 warm water systems, with a distinct pattern of serogroups between the two locations. Legionella of the same serogroups as those isolated from patients were present in each hospital water supply. The isolates were further typed by monoclonal antibodies and by genomic macrorestriction analysis. Similarity between clinical and environmental isolates was found in seven cases. In these cases, acquisition from the hospital water supply appears very likely. The strains of the remaining three patients did not match those in hospital water, suggesting that community-acquired legionellosis was occurring as well. This study suggests that routinely culturing respiratory tract secretions of pneumonia patients for legionella can help diagnose unsuspected cases of legionellosis. Typing legionella strains beyond the serogroup level with tools such as macrorestriction analysis is useful to define sources of infection, which can then be targeted for control measures..

Medienart:	E-Artikel

Erscheinungsjahr:	1999
Erschienen:	1999

Enthalten in:	Zur Gesamtaufnahme - volume:41
Enthalten in:	The journal of hospital infection - 41(1999), 4, Seite 301-311

Sprache:	Englisch

Beteiligte Personen:	Köhler, Julia Ruth [VerfasserIn] Maiwald, Matthias [VerfasserIn] Lück, P. C. [VerfasserIn] Helbig, J. H. [VerfasserIn] Hingst, Volker, 1948- [VerfasserIn] Sonntag, Hans-Günther, 1938- [VerfasserIn]

Links:	Volltext [lizenzpflichtig] Volltext [lizenzpflichtig]

Themen:	Adult Aged Community-Acquired Infections Cross Infection Electrophoresis, Gel, Pulsed-Field Female Germany Humans Infection Control Legionella pneumophila Legionnaires' Disease Male Middle Aged Retrospective Studies Sputum Trachea Water Microbiology Water Supply

Anmerkungen:	Gesehen am 22.03.2021

Umfang:	11

doi:	10.1053/jhin.1998.0517

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1752012321

Internformat


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245	1	0	\|a Detecting legionellosis by unselected culture of respiratory tract secretions and developing links to hospital water strains \|c J.R. Köhler, M. Maiwald, P.C. Lück, J.H. Helbig, V. Hingst, H.G. Sonntag
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520			\|a For a 13-month period, all respiratory tract secretions submitted for routine bacteriology from a large hospital complex were cultured for legionella, irrespective of clinical diagnosis and laboratory requests. Ten cases of legionellosis were detected in this manner, three of which met a strict epidemiological definition of hospital-acquired. Therefore, the 16 warm-water systems of the hospitals, spread out over two locations, were examined for the presence of legionella. Legionella pneumophila was found in 15 warm water systems, with a distinct pattern of serogroups between the two locations. Legionella of the same serogroups as those isolated from patients were present in each hospital water supply. The isolates were further typed by monoclonal antibodies and by genomic macrorestriction analysis. Similarity between clinical and environmental isolates was found in seven cases. In these cases, acquisition from the hospital water supply appears very likely. The strains of the remaining three patients did not match those in hospital water, suggesting that community-acquired legionellosis was occurring as well. This study suggests that routinely culturing respiratory tract secretions of pneumonia patients for legionella can help diagnose unsuspected cases of legionellosis. Typing legionella strains beyond the serogroup level with tools such as macrorestriction analysis is useful to define sources of infection, which can then be targeted for control measures.
650		4	\|a Adult
650		4	\|a Aged
650		4	\|a Community-Acquired Infections
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650		4	\|a Electrophoresis, Gel, Pulsed-Field
650		4	\|a Female
650		4	\|a Germany
650		4	\|a Humans
650		4	\|a Infection Control
650		4	\|a Legionella pneumophila
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650		4	\|a Male
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650		4	\|a Retrospective Studies
650		4	\|a Sputum
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912			\|a GBV_ILN_374
912			\|a GBV_ILN_602
912			\|a GBV_ILN_647
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
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912			\|a GBV_ILN_2010
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912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2043
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
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912			\|a GBV_ILN_2522
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912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
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Detecting legionellosis by unselected culture of respiratory tract secretions and developing links to hospital water strains / J.R. Köhler, M. Maiwald, P.C. Lück, J.H. Helbig, V. Hingst, H.G. Sonntag

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