Details der Publikation - Humoral immune response to autologous blood transfusion in hip surgery

Humoral immune response to autologous blood transfusion in hip surgery : whole blood versus packed red cells and plasma / B. Tolksdorf, T. Frietsch, M. Quintel, M. Kirschfink, P. Becker, A. Lorentz

BACKGROUND AND OBJECTIVES: The immune response to the transfused autologous buffy coat content in whole blood has, to date, not been studied in detail. SUBJECTS AND METHODS: Patients undergoing hip arthroplasty were studied according to whether they received autologous whole blood (WB) (n = 30), autologous fresh-frozen plasma and buffy coat-poor red cells (RC) (n = 40), or no transfusion (NT) (n = 27). Plasma levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and complement SC5b-9 were analysed by enzyme-linked immunosorbent assay (ELISA) 7 days after surgery. RESULTS: There were no significant between-group differences regarding the time course of TNF-alpha, IL-6 and complement SC5b-9 plasma level changes, the infection rate, or the length of hospital stay. CONCLUSION: In comparison to the impact of surgery on cytokine and complement levels, the transfusion of autologous buffy coat is not relevant..

Medienart:	E-Artikel

Erscheinungsjahr:	2001
Erschienen:	2001

Enthalten in:	Zur Gesamtaufnahme - volume:81
Enthalten in:	Vox sanguinis - 81(2001), 3, Seite 180-186

Sprache:	Englisch

Beteiligte Personen:	Tolksdorf, Bernd, 1960- [VerfasserIn] Frietsch, Thomas, 1962- [VerfasserIn] Quintel, Michael, 1954- [VerfasserIn] Kirschfink, Michael [VerfasserIn] Becker, P. [VerfasserIn] Weiler-Lorentz, Arnulf [VerfasserIn]

Links:	Volltext [lizenzpflichtig] Volltext [lizenzpflichtig]

Themen:	Adult Aged Antibody Formation Arthroplasty, Replacement, Hip Blood Component Transfusion Blood Preservation Blood Transfusion, Autologous Cohort Studies Complement Membrane Attack Complex Complement System Proteins Cryopreservation Female Glycoproteins Humans Infections Inflammation Mediators Interleukin-6 Length of Stay Male Middle Aged Time Factors Tumor Necrosis Factor-alpha

Anmerkungen:	First published: 28 July 2009 Gesehen am 15.02.2021

Umfang:	7

doi:	10.1046/j.1423-0410.2001.00106.x

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1748282158

Internformat


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245	1	0	\|a Humoral immune response to autologous blood transfusion in hip surgery \|b whole blood versus packed red cells and plasma \|c B. Tolksdorf, T. Frietsch, M. Quintel, M. Kirschfink, P. Becker, A. Lorentz
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520			\|a BACKGROUND AND OBJECTIVES: The immune response to the transfused autologous buffy coat content in whole blood has, to date, not been studied in detail. SUBJECTS AND METHODS: Patients undergoing hip arthroplasty were studied according to whether they received autologous whole blood (WB) (n = 30), autologous fresh-frozen plasma and buffy coat-poor red cells (RC) (n = 40), or no transfusion (NT) (n = 27). Plasma levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and complement SC5b-9 were analysed by enzyme-linked immunosorbent assay (ELISA) 7 days after surgery. RESULTS: There were no significant between-group differences regarding the time course of TNF-alpha, IL-6 and complement SC5b-9 plasma level changes, the infection rate, or the length of hospital stay. CONCLUSION: In comparison to the impact of surgery on cytokine and complement levels, the transfusion of autologous buffy coat is not relevant.
650		4	\|a Adult
650		4	\|a Aged
650		4	\|a Antibody Formation
650		4	\|a Arthroplasty, Replacement, Hip
650		4	\|a Blood Component Transfusion
650		4	\|a Blood Preservation
650		4	\|a Blood Transfusion, Autologous
650		4	\|a Cohort Studies
650		4	\|a Complement Membrane Attack Complex
650		4	\|a Complement System Proteins
650		4	\|a Cryopreservation
650		4	\|a Female
650		4	\|a Glycoproteins
650		4	\|a Humans
650		4	\|a Infections
650		4	\|a Inflammation Mediators
650		4	\|a Interleukin-6
650		4	\|a Length of Stay
650		4	\|a Male
650		4	\|a Middle Aged
650		4	\|a Time Factors
650		4	\|a Tumor Necrosis Factor-alpha
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912			\|a GBV_ILN_4338
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912			\|a GBV_ILN_4700
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Humoral immune response to autologous blood transfusion in hip surgery : whole blood versus packed red cells and plasma / B. Tolksdorf, T. Frietsch, M. Quintel, M. Kirschfink, P. Becker, A. Lorentz

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