Autophagy and Cancer

This book covers current advances in autophagy research, including such developments as molecular machinery for autophagy induction and regulation, how to target autophagy and modulation of autophagy and drug discovery for cancer prevention and treatment..

Intro -- Autophagy and Cancer -- Preface -- Contents -- Contributors -- Chapter 1: Historical Overview of Autophagy -- 1 Introduction -- 2 In the Beginning … -- 2.1 Lysosomes and Protein Turnover -- 2.2 Microautophagy and Macroautophagy -- 2.3 Kinetics and Mechanics of Autophagy -- 2.4 Exogenous and Endogenous Regulation of Autophagy -- 3 Landmark Discoveries … -- 3.1 Characterization of Autophagy in Yeast Models -- 3.2 Identification and Cloning of ATG Genes -- 3.3 Selective Autophagy -- 3.4 Transgenic and Knockout Mice Models -- 4 Summary -- References -- Chapter 2: The Core Molecular Machinery of Autophagosome Formation -- 1 Introduction -- 2 The Yeast Atg1 Complex -- 2.1 Yeast Atg1 Kinase Complex -- 2.2 Atg1 -- 2.3 Atg13 -- 2.4 Atg17-Atg31-Atg29 -- 3 Mammalian ULK1/2 Complex -- 3.1 The Mammalian Atg1 Homolog -- 3.2 ULK1/ULK2 Complex -- 4 Atg9 and Its Cycling System -- 4.1 Yeast Atg9 and Its Cycling Regulation -- 4.2 Atg9 Localization to the PAS -- 4.3 Atg9 Retrieval from the PAS -- 4.4 Mammalian ATG9 -- 5 The PtdIns3K Complexes -- 5.1 Yeast PtdIns3K Complex I -- 5.2 Vps34-Vps15-Vps30 -- 5.3 Atg14 -- 5.4 Mammalian Class III PtdIns3K -- 5.5 PIK3C3 and PIK3R4 -- 5.6 BECN1 -- 5.7 ATG14 -- 5.8 UVRAG, SH3GLB1, and KIAA0226 -- 6 Ubiquitin-Like Conjugation Systems -- 6.1 Two Ubl Conjugation Systems in Yeast -- 6.2 Atg12-Atg5 Conjugation System -- 6.3 Atg8-PE Conjugation System -- 6.4 Mammalian Ubl Conjugation Systems -- 6.5 Mammalian Atg12 Conjugation System -- 6.6 Mammalian Atg8 Conjugation System -- 7 Conclusion -- References -- Chapter 3: The Origin of Autophagosomes: The Beginning of an End -- 1 Introduction -- 1.1 The Autophagosomes -- 1.2 The Autophagosomal Precursor Structures -- 1.3 The Key Actors: The Atg Proteins -- 2 Where Are Autophagosomes Originating From?..

Medienart:	E-Book

Erscheinungsjahr:	2013 ©2013
Erschienen:	New York, NY: Springer New York ; 2013 ©2013
Ausgabe:	1st ed.

Reihe:	Current Cancer Research Ser. - v.8

Sprache:	Englisch

Beteiligte Personen:	Wang, Hong-Gang [VerfasserIn]

Links:	ebookcentral.proquest.com [lizenzpflichtig]

ISBN:	978-1-4614-6561-4

Themen:	Cancer ; Immunological aspects Carcinogenesis.. Electronic books

Anmerkungen:	Description based on publisher supplied metadata and other sources

Umfang:	1 online resource (266 pages)

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1746265329